Structural determinants within Pbx1 that mediate cooperative DNA binding with pentapeptide-containing Hox proteins: proposal for a model of a Pbx1-Hox-DNA complex
about
Functional cloning and characterization of a novel nonhomeodomain protein that inhibits the binding of PBX1-HOX complexes to DNAThe AD1 and AD2 transactivation domains of E2A are essential for the antiapoptotic activity of the chimeric oncoprotein E2A-HLFPrep1, a novel functional partner of Pbx proteins.The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativityTranscriptional repression of peri-implantation EMX2 expression in mammalian reproduction by HOXA10The HOX homeodomain proteins block CBP histone acetyltransferase activityPBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteinsHOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cellsAbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteinsMeis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1Structure of a DNA-bound Ultrabithorax-Extradenticle homeodomain complexLock and key binding of the HOX YPWM peptide to the PBX homeodomainTALE homeoproteins as HOX11-interacting partners in T-cell leukemiaHOXB4 homeodomain protein is expressed in developing epidermis and skin disorders and modulates keratinocyte proliferationA conserved C-terminal domain in PBX increases DNA binding by the PBX homeodomain and is not a primary site of contact for the YPWM motif of HOXA1The HoxB1 hexapeptide is a prefolded domain: implications for the Pbx1/Hox interactionMeis proteins are major in vivo DNA binding partners for wild-type but not chimeric Pbx proteinsDNA binding and transcriptional activation by a PDX1.PBX1b.MEIS2b trimer and cooperation with a pancreas-specific basic helix-loop-helix complexGenome-wide analysis of the binding of the Hox protein Ultrabithorax and the Hox cofactor Homothorax in DrosophilaAn Abd-B class HOX.PBX recognition sequence is required for expression from the mouse Ren-1c gene.HoxB8 requires its Pbx-interaction motif to block differentiation of primary myeloid progenitors and of most cell line models of myeloid differentiation.Minimization of a protein-DNA dimerizerPurification of the Prep1 interactome identifies novel pathways regulated by Prep1.Hox specificity unique roles for cofactors and collaborators.Comparing anterior and posterior Hox complex formation reveals guidelines for predicting cis-regulatory elementsSpecific protein-protein interaction between basic helix-loop-helix transcription factors and homeoproteins of the Pitx family.Congenital diaphragmatic hernia candidate genes derived from embryonic transcriptomes.Hox genes and their candidate downstream targets in the developing central nervous system.The Homothorax homeoprotein activates the nuclear localization of another homeoprotein, extradenticle, and suppresses eye development in Drosophila.A novel role for the AAA ATPase spastin as a HOXA10 transcriptional corepressor in Ishikawa endometrial cellsA balance between two nuclear localization sequences and a nuclear export sequence governs extradenticle subcellular localization.The Hox cooperativity motif of the chimeric oncoprotein E2a-Pbx1 is necessary and sufficient for oncogenesis.Mesodermal expression of the C. elegans HMX homolog mls-2 requires the PBC homolog CEH-20Hoxb1 enhancer and control of rhombomere 4 expression: complex interplay between PREP1-PBX1-HOXB1 binding sites.Site-directed mutagenesis and footprinting analysis of the interaction of the sunflower KNOX protein HAKN1 with DNA.Pbx-1 Hox heterodimers bind DNA on inseparable half-sites that permit intrinsic DNA binding specificity of the Hox partner at nucleotides 3' to a TAAT motif.E2a-Pbx1 induces aberrant expression of tissue-specific and developmentally regulated genes when expressed in NIH 3T3 fibroblastsConformational changes induced in Hoxb-8/Pbx-1 heterodimers in solution and upon interaction with specific DNASite-specific heterodimerization by paired class homeodomain proteins mediates selective transcriptional responses.An inhibitory switch derepressed by pbx, hox, and Meis/Prep1 partners regulates DNA-binding by pbx1 and E2a-pbx1 and is dispensable for myeloid immortalization by E2a-pbx1.
P2860
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P2860
Structural determinants within Pbx1 that mediate cooperative DNA binding with pentapeptide-containing Hox proteins: proposal for a model of a Pbx1-Hox-DNA complex
description
1996 nî lūn-bûn
@nan
1996 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Structural determinants within ...... odel of a Pbx1-Hox-DNA complex
@ast
Structural determinants within ...... odel of a Pbx1-Hox-DNA complex
@en
Structural determinants within ...... odel of a Pbx1-Hox-DNA complex
@en-gb
Structural determinants within ...... odel of a Pbx1-Hox-DNA complex
@nl
type
label
Structural determinants within ...... odel of a Pbx1-Hox-DNA complex
@ast
Structural determinants within ...... odel of a Pbx1-Hox-DNA complex
@en
Structural determinants within ...... odel of a Pbx1-Hox-DNA complex
@en-gb
Structural determinants within ...... odel of a Pbx1-Hox-DNA complex
@nl
prefLabel
Structural determinants within ...... odel of a Pbx1-Hox-DNA complex
@ast
Structural determinants within ...... odel of a Pbx1-Hox-DNA complex
@en
Structural determinants within ...... odel of a Pbx1-Hox-DNA complex
@en-gb
Structural determinants within ...... odel of a Pbx1-Hox-DNA complex
@nl
P2860
P356
P1476
Structural determinants within ...... odel of a Pbx1-Hox-DNA complex
@en
P2860
P304
P356
10.1128/MCB.16.4.1632
P407
P577
1996-04-01T00:00:00Z