Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2
about
Primary systemic carnitine deficiency is caused by mutations in a gene encoding sodium ion-dependent carnitine transporterL-Carnitine transport in human placental brush-border membranes is mediated by the sodium-dependent organic cation transporter OCTN2Molecular identification of a novel carnitine transporter specific to human testis. Insights into the mechanism of carnitine recognitionDiscovery of the ergothioneine transporterNew insights concerning the role of carnitine in the regulation of fuel metabolism in skeletal muscleStrategies of bacterial over expression of membrane transporters relevant in human health: the successful case of the three members of OCTN subfamilyRole of solute carriers in response to anticancer drugsTransporters at CNS barrier sites: obstacles or opportunities for drug delivery?Renal drug transporters and their significance in drug-drug interactionsDistinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genomeMutations of OCTN2, an organic cation/carnitine transporter, lead to deficient cellular carnitine uptake in primary carnitine deficiencyFunctional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporterA missense mutation in the OCTN2 gene associated with residual carnitine transport activityGenetic epidemiology of the carnitine transporter OCTN2 gene in a Japanese population and phenotypic characterization in Japanese pedigrees with primary systemic carnitine deficiencyExpression and localization of organic cation/carnitine transporter OCTN2 in Caco-2 cellsFunctional domains in the carnitine transporter OCTN2, defective in primary carnitine deficiencyDevelopment and characterization of an animal model of carnitine deficiencyRegulation of human organic cation transporter hOCT2 by PKA, PI3K, and calmodulin-dependent kinasesNa+- and Cl--coupled active transport of carnitine by the amino acid transporter ATB(0,+) from mouse colon expressed in HRPE cells and Xenopus oocytesGenomic interval engineering of mice identifies a novel modulator of triglyceride productionCarnitine content and expression of mitochondrial beta-oxidation enzymes in placentas of wild-type (OCTN2(+/+)) and OCTN2 Null (OCTN2(-/-)) MiceMolecular cloning and characterization of TPP36 and its isoform TPP32, novel substrates of Abl tyrosine kinaseMolecular and functional characterization of organic cation/carnitine transporter family in miceDifferent involvement of promoter methylation in the expression of organic cation/carnitine transporter 2 (OCTN2) in cancer cell linesCaveolin-1--a novel interacting partner of organic cation/carnitine transporter (Octn2): effect of protein kinase C on this interaction in rat astrocytesComplementation of the Yeast Model System Reveals that Caenorhabditis elegans OCT-1 Is a Functional Transporter of AnthracyclinesEvolutionary Analysis and Classification of OATs, OCTs, OCTNs, and Other SLC22 Transporters: Structure-Function Implications and Analysis of Sequence MotifsVentricular choline transport: a role for organic cation transporter 2 expressed in choroid plexusIdentity of the organic cation transporter OCT3 as the extraneuronal monoamine transporter (uptake2) and evidence for the expression of the transporter in the brainbeta-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporterDysfunctions of the epididymis as a result of primary carnitine deficiency in juvenile visceral steatosis miceA moderate excess of dietary lysine lowers plasma and tissue carnitine concentrations in pigs.PPAR alpha mediates transcriptional upregulation of novel organic cation transporters-2 and -3 and enzymes involved in hepatic carnitine synthesis.Dietary oxidised fat up regulates the expression of organic cation transporters in liver and small intestine and alters carnitine concentrations in liver, muscle and plasma of rats.A mutation in SLC22A4 encoding an organic cation transporter expressed in the cochlea strial endothelium causes human recessive non-syndromic hearing loss DFNB60Localization of organic cation/carnitine transporter (OCTN2) in cells forming the blood-brain barrier.Isolation and functional characterization of a novel organic solute carrier protein, hOSCP1.Evidence for the association of the SLC22A4 and SLC22A5 genes with type 1 diabetes: a case control study.Active efflux across the blood-brain barrier: role of the solute carrier family.Medium chain acylcarnitines dominate the metabolite pattern in humans under moderate intensity exercise and support lipid oxidation
P2860
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P2860
Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2
description
1998 nî lūn-bûn
@nan
1998 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Molecular and functional ident ...... an carnitine transporter OCTN2
@ast
Molecular and functional ident ...... an carnitine transporter OCTN2
@en
Molecular and functional ident ...... an carnitine transporter OCTN2
@en-gb
Molecular and functional ident ...... an carnitine transporter OCTN2
@nl
type
label
Molecular and functional ident ...... an carnitine transporter OCTN2
@ast
Molecular and functional ident ...... an carnitine transporter OCTN2
@en
Molecular and functional ident ...... an carnitine transporter OCTN2
@en-gb
Molecular and functional ident ...... an carnitine transporter OCTN2
@nl
prefLabel
Molecular and functional ident ...... an carnitine transporter OCTN2
@ast
Molecular and functional ident ...... an carnitine transporter OCTN2
@en
Molecular and functional ident ...... an carnitine transporter OCTN2
@en-gb
Molecular and functional ident ...... an carnitine transporter OCTN2
@nl
P2093
P3181
P356
P1476
Molecular and functional ident ...... an carnitine transporter OCTN2
@en
P2093
H Yabuuchi
P304
P3181
P356
10.1074/JBC.273.32.20378
P407
P577
1998-08-07T00:00:00Z