Dynamics, stability and iron-binding activity of frataxin clinical mutants
about
Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examplesUnderstanding the genetic and molecular pathogenesis of Friedreich's ataxia through animal and cellular modelsEmerging critical roles of Fe-S clusters in DNA replication and repair.Friedreich’s Ataxia Variants I154F and W155R Diminish Frataxin-Based Activation of the Iron–Sulfur Cluster Assembly ComplexThe first cellular models based on frataxin missense mutations that reproduce spontaneously the defects associated with Friedreich ataxiaProtein stability and dynamics modulation: the case of human frataxinThe alteration of the C-terminal region of human frataxin distorts its structural dynamics and function.Iron-binding activity in yeast frataxin entails a trade off with stability in the alpha1/beta1 acidic ridge regionProbing the kinetic stabilities of Friedreich's ataxia clinical variants using a solid phase GroEL chaperonin capture platform.Effector role reversal during evolution: the case of frataxin in Fe-S cluster biosynthesis.Analyzing the Effects of a G137V Mutation in the FXN Gene.Neurodegeneration in Friedreich's ataxia: from defective frataxin to oxidative stressFrataxin: a protein in search for a function.Animal and cellular models of Friedreich ataxia.Dysregulation of cellular iron metabolism in Friedreich ataxia: from primary iron-sulfur cluster deficit to mitochondrial iron accumulation.Human Frataxin Folds Via an Intermediate State. Role of the C-Terminal Region.Compound heterozygous FXN mutations and clinical outcome in friedreich ataxia.The role of the N-terminal tail for the oligomerization, folding and stability of human frataxinThe kinetics of folding of frataxin
P2860
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P2860
Dynamics, stability and iron-binding activity of frataxin clinical mutants
description
2008 nî lūn-bûn
@nan
2008 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Dynamics, stability and iron-binding activity of frataxin clinical mutants
@ast
Dynamics, stability and iron-binding activity of frataxin clinical mutants
@en
Dynamics, stability and iron-binding activity of frataxin clinical mutants
@en-gb
Dynamics, stability and iron-binding activity of frataxin clinical mutants
@nl
type
label
Dynamics, stability and iron-binding activity of frataxin clinical mutants
@ast
Dynamics, stability and iron-binding activity of frataxin clinical mutants
@en
Dynamics, stability and iron-binding activity of frataxin clinical mutants
@en-gb
Dynamics, stability and iron-binding activity of frataxin clinical mutants
@nl
prefLabel
Dynamics, stability and iron-binding activity of frataxin clinical mutants
@ast
Dynamics, stability and iron-binding activity of frataxin clinical mutants
@en
Dynamics, stability and iron-binding activity of frataxin clinical mutants
@en-gb
Dynamics, stability and iron-binding activity of frataxin clinical mutants
@nl
P2860
P50
P1433
P1476
Dynamics, stability and iron-binding activity of frataxin clinical mutants
@en
P2093
Ana R Correia
Chiara Pastore
P2860
P304
P356
10.1111/J.1742-4658.2008.06512.X
P407
P577
2008-07-01T00:00:00Z