Differential genomic targeting of the transcription factor TAL1 in alternate haematopoietic lineages
about
Intrinsic epigenetic regulation of the D4Z4 macrosatellite repeat in a transgenic mouse model for FSHDA Runx1-Smad6 rheostat controls Runx1 activity during embryonic hematopoiesisMolecular roadblocks for cellular reprogrammingEpigenetic mechanisms and developmental choice hierarchies in T-lymphocyte developmentMiR-146b negatively regulates migration and delays progression of T-cell acute lymphoblastic leukemiaStructural Basis for LMO2-Driven Recruitment of the SCL:E47bHLH Heterodimer to Hematopoietic-Specific Transcriptional TargetsThe LMO2 oncogene regulates DNA replication in hematopoietic cellsAssociation of levels of fasting glucose and insulin with rare variants at the chromosome 11p11.2-MADD locus: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing StudyAnnotation of functional variation in personal genomes using RegulomeDBIdentification of biologically relevant enhancers in human erythroid cells.Target analysis by integration of transcriptome and ChIP-seq data with BETA.Large-scale quality analysis of published ChIP-seq data."Upstream Analysis": An Integrated Promoter-Pathway Analysis Approach to Causal Interpretation of Microarray Data.A Src family kinase-Shp2 axis controls RUNX1 activity in megakaryocyte and T-lymphocyte differentiation.Splicing factor SF3B1K700E mutant dysregulates erythroid differentiation via aberrant alternative splicing of transcription factor TAL1.DUX4 activates germline genes, retroelements, and immune mediators: implications for facioscapulohumeral dystrophy.Models of human core transcriptional regulatory circuitries.Dynamic shifts in occupancy by TAL1 are guided by GATA factors and drive large-scale reprogramming of gene expression during hematopoiesis.Ectopic expression of homeobox gene NKX2-1 in diffuse large B-cell lymphoma is mediated by aberrant chromatin modifications.Genome-wide transcription factor binding: beyond direct target regulation.Comprehensive functional annotation of seventy-one breast cancer risk Loci.Important biological information uncovered in previously unaligned reads from chromatin immunoprecipitation experiments (ChIP-Seq).Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators.Occupancy by key transcription factors is a more accurate predictor of enhancer activity than histone modifications or chromatin accessibility.The hypersensitive sites of the murine β-globin locus control region act independently to affect nuclear localization and transcriptional elongation.Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia.High-throughput screening in niche-based assay identifies compounds to target preleukemic stem cells.GATA-binding protein 4 (GATA-4) and T-cell acute leukemia 1 (TAL1) regulate myogenic differentiation and erythropoietin response via cross-talk with Sirtuin1 (Sirt1)Control of developmentally primed erythroid genes by combinatorial co-repressor actionsDynamic interaction between TAL1 oncoprotein and LSD1 regulates TAL1 function in hematopoiesis and leukemogenesis.Comparison of genome-wide binding of MyoD in normal human myogenic cells and rhabdomyosarcomas identifies regional and local suppression of promyogenic transcription factors.Distinct Activities of Myf5 and MyoD Indicate Separate Roles in Skeletal Muscle Lineage Specification and Differentiation.UTX inhibition as selective epigenetic therapy against TAL1-driven T-cell acute lymphoblastic leukemiaTissue-specific splicing of a ubiquitously expressed transcription factor is essential for muscle differentiationThe TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemiaMechanism governing a stem cell-generating cis-regulatory element.The hematopoietic regulator TAL1 is required for chromatin looping between the β-globin LCR and human γ-globin genes to activate transcription.Concise review: Blood relatives: formation and regulation of hematopoietic stem cells by the basic helix-loop-helix transcription factors stem cell leukemia and lymphoblastic leukemia-derived sequence 1.RUNX family: Regulation and diversification of roles through interacting proteins.LIM-domain-only proteins in cancer.
P2860
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P2860
Differential genomic targeting of the transcription factor TAL1 in alternate haematopoietic lineages
description
2011 nî lūn-bûn
@nan
2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Differential genomic targeting ...... ernate haematopoietic lineages
@ast
Differential genomic targeting ...... ernate haematopoietic lineages
@en
Differential genomic targeting ...... ernate haematopoietic lineages
@en-gb
Differential genomic targeting ...... ernate haematopoietic lineages
@nl
type
label
Differential genomic targeting ...... ernate haematopoietic lineages
@ast
Differential genomic targeting ...... ernate haematopoietic lineages
@en
Differential genomic targeting ...... ernate haematopoietic lineages
@en-gb
Differential genomic targeting ...... ernate haematopoietic lineages
@nl
prefLabel
Differential genomic targeting ...... ernate haematopoietic lineages
@ast
Differential genomic targeting ...... ernate haematopoietic lineages
@en
Differential genomic targeting ...... ernate haematopoietic lineages
@en-gb
Differential genomic targeting ...... ernate haematopoietic lineages
@nl
P2093
P2860
P50
P3181
P356
P1433
P1476
Differential genomic targeting ...... ernate haematopoietic lineages
@en
P2093
Carmen G Palii
Carolina Perez-Iratxeta
Fengtao Dai
Harold Atkins
Jerry Davison
Marjorie Brand
Stephen J Tapscott
Zizhen Yao
P2860
P304
P3181
P356
10.1038/EMBOJ.2010.342
P407
P577
2010-12-21T00:00:00Z