HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system
about
Huntingtin interacting protein 1 induces apoptosis via a novel caspase-dependent death effector domainMyopalladin, a novel 145-kilodalton sarcomeric protein with multiple roles in Z-disc and I-band protein assembliesClathrin- and AP-2-binding sites in HIP1 uncover a general assembly role for endocytic accessory proteinsHuntingtin interacting protein 1 Is a clathrin coat binding protein required for differentiation of late spermatogenic progenitorsHIP1 and HIP12 display differential binding to F-actin, AP2, and clathrin. Identification of a novel interaction with clathrin light chainIdentification of VCP/p97, carboxyl terminus of Hsp70-interacting protein (CHIP), and amphiphysin II interaction partners using membrane-based human proteome arraysReplacement of charged and polar residues in the coiled-coiled interface of huntingtin-interacting protein 1 (HIP1) causes aggregation and cell deathHuntingtin-interacting protein 1-mediated neuronal cell death occurs through intrinsic apoptotic pathways and mitochondrial alterationsHuntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptorsHuntingtin-interacting protein 1 (Hip1) and Hip1-related protein (Hip1R) bind the conserved sequence of clathrin light chains and thereby influence clathrin assembly in vitro and actin distribution in vivoA human HAP1 homologue. Cloning, expression, and interaction with huntingtinpARIS-htt: an optimised expression platform to study huntingtin reveals functional domains required for vesicular traffickingHIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brainThe Phox homology (PX) domain, a new player in phosphoinositide signallingDisabled-2 exhibits the properties of a cargo-selective endocytic clathrin adaptorRNAi-mediated Hip1R silencing results in stable association between the endocytic machinery and the actin assembly machinery.The Gln-Ala repeat transcriptional activator CA150 interacts with huntingtin: neuropathologic and genetic evidence for a role in Huntington's disease pathogenesisThe localization and interactions of huntingtinInteractions within the mammalian DNA methyltransferase familyCrystal Structure at 2.8 Å of Huntingtin-Interacting Protein 1 (HIP1) Coiled-Coil Domain Reveals a Charged Surface Suitable for HIP1 Protein Interactor (HIPPI)Accommodation of structural rearrangements in the huntingtin-interacting protein 1 coiled-coil domainNovel protein kinases Ark1p and Prk1p associate with and regulate the cortical actin cytoskeleton in budding yeast.Scd5p and clathrin function are important for cortical actin organization, endocytosis, and localization of sla2p in yeast.Sla2p is associated with the yeast cortical actin cytoskeleton via redundant localization signals.Actin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chainAberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtinExpression of mutant huntingtin blocks exocytosis in PC12 cells by depletion of complexin IIHuntingtin-interacting protein 1 is overexpressed in prostate and colon cancer and is critical for cellular survivalHuntingtin-associated protein 1 interacts with hepatocyte growth factor-regulated tyrosine kinase substrate and functions in endosomal traffickingHuntington's disease: roles of huntingtin-interacting protein 1 (HIP-1) and its molecular partner HIPPI in the regulation of apoptosis and transcriptionHippi is essential for node cilia assembly and Sonic hedgehog signalingDisruption of the endocytic protein HIP1 results in neurological deficits and decreased AMPA receptor traffickingHAP1-huntingtin interactions do not contribute to the molecular pathology in Huntington's disease transgenic miceAn actin-binding protein of the Sla2/Huntingtin interacting protein 1 family is a novel component of clathrin-coated pits and vesiclesThe actin-binding protein Hip1R associates with clathrin during early stages of endocytosis and promotes clathrin assembly in vitroHuntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansionIdentification of hepta-histidine as a candidate drug for Huntington's disease by in silico-in vitro- in vivo-integrated screens of chemical librariesProteomic analysis of wild-type and mutant huntingtin-associated proteins in mouse brains identifies unique interactions and involvement in protein synthesis.Inactivation of Drosophila Huntingtin affects long-term adult functioning and the pathogenesis of a Huntington's disease model.Mutant huntingtin can paradoxically protect neurons from death.
P2860
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P2860
HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system
description
1997 nî lūn-bûn
@nan
1997 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի մարտին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system
@ast
HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system
@en
HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system
@en-gb
HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system
@nl
type
label
HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system
@ast
HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system
@en
HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system
@en-gb
HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system
@nl
prefLabel
HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system
@ast
HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system
@en
HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system
@en-gb
HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system
@nl
P2093
P2860
P3181
P356
P1476
HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system
@en
P2093
E E Wanker
E Scherzinger
J Colicelli
R Hasenbank
P2860
P304
P3181
P356
10.1093/HMG/6.3.487
P407
P50
P577
1997-03-01T00:00:00Z