SIRT1 deacetylates APE1 and regulates cellular base excision repair
about
Human AP endonuclease (APE1/Ref-1) and its acetylation regulate YB-1-p300 recruitment and RNA polymerase II loading in the drug-induced activation of multidrug resistance gene MDR1Dynamic Regulation of APE1/Ref-1 as a Therapeutic Target ProteinPotential Modulation of Sirtuins by Oxidative StressThe current state of eukaryotic DNA base damage and repairProtective effects and mechanisms of sirtuins in the nervous systemTargeting histone deacetylases for cancer therapy: from molecular mechanisms to clinical implicationsBase excision repair and cancerSirtuins in epigenetic regulationBase Excision Repair, a Pathway Regulated by Posttranslational ModificationsDifferential expression of APE1 and APE2 in germinal centers promotes error-prone repair and A:T mutations during somatic hypermutationDietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cellsReactive oxygen species, cellular redox systems, and apoptosisNuclear DNA damage signalling to mitochondria in ageingEmerging Roles of SIRT1 in Cancer Drug ResistanceNucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cellsCritical lysine residues within the overlooked N-terminal domain of human APE1 regulate its biological functions.Metabolic control of the epigenome in systemic Lupus erythematosus.Histone/protein deacetylase SIRT1 is an anticancer therapeutic target.APE1/Ref-1 as an emerging therapeutic target for various human diseases: phytochemical modulation of its functionsRepair of endogenous DNA base lesions modulate lifespan in miceNucleolin and nucleophosmin: nucleolar proteins with multiple functions in DNA repair.Posttranslational modification of mammalian AP endonuclease (APE1).2, 3, 5, 4'-Tetrahydroxystilbene-2-O-beta-D-glucoside improves gastrointestinal motility disorders in STZ-induced diabetic mice.Apurinic/apyrimidinic endonuclease 1 is a key modulator of aluminum-induced neuroinflammationRedox factor-1 activates endothelial SIRTUIN1 through reduction of conserved cysteine sulfhydryls in its deacetylase domain.Dual regulatory roles of human AP-endonuclease (APE1/Ref-1) in CDKN1A/p21 expressionKnock-in reconstitution studies reveal an unexpected role of Cys-65 in regulating APE1/Ref-1 subcellular trafficking and functionInhibitors of the apurinic/apyrimidinic endonuclease 1 (APE1)/nucleophosmin (NPM1) interaction that display anti-tumor propertiesCombined exercise and insulin-like growth factor-1 supplementation induces neurogenesis in old rats, but do not attenuate age-associated DNA damageUbiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stabilityHistone deacetylase SIRT1 modulates and deacetylates DNA base excision repair enzyme thymine DNA glycosylase.The transposon-driven evolutionary origin and basis of histone deacetylase functions and limitations in disease prevention.Protein deacetylation by sirtuins: delineating a post-translational regulatory program responsive to nutrient and redox stressorsAltered Secretory Activity of APE1/Ref-1 D148E Variants Identified in Human Patients With Bladder Cancer.Enhanced inhibition of clonogenic survival of human medulloblastoma cells by multimodal treatment with ionizing irradiation, epigenetic modifiers, and differentiation-inducing drugsSIRT1 is a Highly Networked Protein That Mediates the Adaptation to Chronic Physiological Stress.Regulation of limited N-terminal proteolysis of APE1 in tumor via acetylation and its role in cell proliferation.The emerging and diverse roles of sirtuins in cancer: a clinical perspective.Chromatin modifications associated with DNA double-strand breaks repair as potential targets for neurological diseases.Prediction of survival prognosis of non-small cell lung cancer by APE1 through regulation of Epithelial-Mesenchymal Transition.
P2860
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P248
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P2860
SIRT1 deacetylates APE1 and regulates cellular base excision repair
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
SIRT1 deacetylates APE1 and regulates cellular base excision repair
@ast
SIRT1 deacetylates APE1 and regulates cellular base excision repair
@en
SIRT1 deacetylates APE1 and regulates cellular base excision repair
@en-gb
SIRT1 deacetylates APE1 and regulates cellular base excision repair
@nl
type
label
SIRT1 deacetylates APE1 and regulates cellular base excision repair
@ast
SIRT1 deacetylates APE1 and regulates cellular base excision repair
@en
SIRT1 deacetylates APE1 and regulates cellular base excision repair
@en-gb
SIRT1 deacetylates APE1 and regulates cellular base excision repair
@nl
prefLabel
SIRT1 deacetylates APE1 and regulates cellular base excision repair
@ast
SIRT1 deacetylates APE1 and regulates cellular base excision repair
@en
SIRT1 deacetylates APE1 and regulates cellular base excision repair
@en-gb
SIRT1 deacetylates APE1 and regulates cellular base excision repair
@nl
P2093
P2860
P921
P3181
P356
P1476
SIRT1 deacetylates APE1 and regulates cellular base excision repair
@en
P2093
Asma Naqvi
Ilwola Mattagajasingh
Jeremy DeRicco
Kenji Kasuno
Saet-Byel Jung
Timothy A Hoffman
Tohru Yamamori
P2860
P304
P3181
P356
10.1093/NAR/GKP1039
P407
P577
2009-11-24T00:00:00Z