Agrin binds to the nerve-muscle basal lamina via laminin
about
Skeletal muscle laminin and MDC1A: pathogenesis and treatment strategies.Form and function: the laminin family of heterotrimersApoptosis inhibitors and mini-agrin have additive benefits in congenital muscular dystrophy miceDevelopmental and pathogenic mechanisms of basement membrane assemblyMechanistic distinctions between agrin and laminin-1 induced aggregation of acetylcholine receptorsAgrin isoforms with distinct amino termini: differential expression, localization, and functionMapping of the laminin-binding site of the N-terminal agrin domain (NtA).Local induction of acetylcholine receptor clustering in myotube cultures using microfluidic application of agrin.Muscle-wide secretion of a miniaturized form of neural agrin rescues focal neuromuscular innervation in agrin mutant mice.An oncogenic role of Agrin in regulating focal adhesion integrity in hepatocellular carcinomaC. elegans agrin is expressed in pharynx, IL1 neurons and distal tip cells and does not genetically interact with genes involved in synaptogenesis or muscle function.The process-inducing activity of transmembrane agrin requires follistatin-like domainsFormation of the neuromuscular junction. Agrin and its unusual receptors.Electron microscopic structure of agrin and mapping of its binding site in laminin-1New role for Agrin in T cells and its potential importance in immune system regulationStill more complexity in mammalian basement membranes.LRP4 is critical for neuromuscular junction maintenanceThe basement membrane/basal lamina of skeletal muscle.Soluble miniagrin enhances contractile function of engineered skeletal muscle.Structure-function analysis of endogenous lectin mind-the-gap in synaptogenesisAgrin can mediate acetylcholine receptor gene expression in muscle by aggregation of muscle-derived neuregulins.Laminin-1 redistributes postsynaptic proteins and requires rapsyn, tyrosine phosphorylation, and Src and Fyn to stably cluster acetylcholine receptors.Laminin polymerization induces a receptor-cytoskeleton networkAgrin mediates chondrocyte homeostasis and requires both LRP4 and α-dystroglycan to enhance cartilage formation in vitro and in vivoTransmembrane form agrin-induced process formation requires lipid rafts and the activation of Fyn and MAPK.Identification of an agrin mutation that causes congenital myasthenia and affects synapse function.Engineering skeletal muscle - from two to three dimensions.Effects of purified recombinant neural and muscle agrin on skeletal muscle fibers in vivo.Site specific cleavage mediated by MMPs regulates function of agrin.Muscle activity and muscle agrin regulate the organization of cytoskeletal proteins and attached acetylcholine receptor (AchR) aggregates in skeletal muscle fibers.Emerging roles for MAP kinases in agrin signaling.The role of laminins in basement membrane function.A minigene of neural agrin encoding the laminin-binding and acetylcholine receptor-aggregating domains is sufficient to induce postsynaptic differentiation in muscle fibres.Conjugation of LG domains of agrins and perlecan to polymerizing laminin-2 promotes acetylcholine receptor clustering.Agrin is required for posterior development and motor axon outgrowth and branching in embryonic zebrafish.Novel SEA and LG2 Agrin mutations causing congenital Myasthenic syndrome.Linker proteins restore basement membrane and correct LAMA2-related muscular dystrophy in mice.Laminin-deficient muscular dystrophy: Molecular pathogenesis and structural repair strategies.Differential expression of agrin in renal basement membranes as revealed by domain-specific antibodies.Linking Extracellular Matrix Agrin to the Hippo Pathway in Liver Cancer and Beyond.
P2860
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P2860
Agrin binds to the nerve-muscle basal lamina via laminin
description
1997 nî lūn-bûn
@nan
1997 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Agrin binds to the nerve-muscle basal lamina via laminin
@ast
Agrin binds to the nerve-muscle basal lamina via laminin
@en
Agrin binds to the nerve-muscle basal lamina via laminin
@en-gb
Agrin binds to the nerve-muscle basal lamina via laminin
@nl
type
label
Agrin binds to the nerve-muscle basal lamina via laminin
@ast
Agrin binds to the nerve-muscle basal lamina via laminin
@en
Agrin binds to the nerve-muscle basal lamina via laminin
@en-gb
Agrin binds to the nerve-muscle basal lamina via laminin
@nl
prefLabel
Agrin binds to the nerve-muscle basal lamina via laminin
@ast
Agrin binds to the nerve-muscle basal lamina via laminin
@en
Agrin binds to the nerve-muscle basal lamina via laminin
@en-gb
Agrin binds to the nerve-muscle basal lamina via laminin
@nl
P2093
P2860
P921
P356
P1476
Agrin binds to the nerve-muscle basal lamina via laminin
@en
P2093
A J Denzer
M Gesemann
R Brandenberger
P2860
P304
P356
10.1083/JCB.137.3.671
P407
P577
1997-05-05T00:00:00Z