Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension
about
Roles of Akt and SGK1 in the Regulation of Renal Tubular TransportUbiquitylation and control of renal Na+ balance and blood pressureA molecular update on pseudohypoaldosteronism type IIStructural and biochemical characterization of the KLHL3–WNK kinase interaction important in blood pressure regulationKelch proteins: emerging roles in skeletal muscle development and diseases.Disease-causing mutations in KLHL3 impair its effect on WNK4 degradationWNK4 is an Adipogenic Factor and Its Deletion Reduces Diet-Induced Obesity in Mice.Mechanism and synergism in epithelial fluid and electrolyte secretion.A novel Ste20-related proline/alanine-rich kinase (SPAK)-independent pathway involving calcium-binding protein 39 (Cab39) and serine threonine kinase with no lysine member 4 (WNK4) in the activation of Na-K-Cl cotransporters.Regulation of with-no-lysine kinase signaling by Kelch-like proteins.WNK4 is the major WNK positively regulating NCC in the mouse kidneyAngiotensin II signaling via protein kinase C phosphorylates Kelch-like 3, preventing WNK4 degradationDistal convoluted tubuleA young child with pseudohypoaldosteronism type II by a mutation of Cullin 3.SPAK deficiency corrects pseudohypoaldosteronism II caused by WNK4 mutation.Generation of WNK1 knockout cell lines by CRISPR/Cas-mediated genome editing.Hyperkalemic hypertension-associated cullin 3 promotes WNK signaling by degrading KLHL3KLHL3 regulates paracellular chloride transport in the kidney by ubiquitination of claudin-8.Ca(2+) is a Regulator of the WNK/OSR1/NKCC Pathway in a Human Salivary Gland Cell Line.Discovery of Novel SPAK Inhibitors That Block WNK Kinase Signaling to Cation Chloride Transporters.Critical role of the SPAK protein kinase CCT domain in controlling blood pressureHypertension-causing Mutations in Cullin3 Protein Impair RhoA Protein Ubiquitination and Augment the Association with Substrate Adaptors.Kelch-Like Protein 2 Mediates Angiotensin II-With No Lysine 3 Signaling in the Regulation of Vascular Tonus.Alternatively spliced proline-rich cassettes link WNK1 to aldosterone actionKLHDC10 Deficiency Protects Mice against TNFα-Induced Systemic Inflammation.A unifying mechanism for WNK kinase regulation of sodium-chloride cotransporterCharacterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia.Towards the Development of Small-Molecule MO25 Binders as Potential Indirect SPAK/OSR1 Kinase Inhibitors.Degradation by Cullin 3 and effect on WNK kinases suggest a role of KLHL2 in the pathogenesis of Familial Hyperkalemic HypertensionOsmotic stress induces the phosphorylation of WNK4 Ser575 via the p38MAPK-MK pathwayGeneration and analysis of knock-in mice carrying pseudohypoaldosteronism type II-causing mutations in the cullin 3 gene.The CUL3/KLHL3-WNK-SPAK/OSR1 pathway as a target for antihypertensive therapyHypertension: the missing WNKs.WNK1-related Familial Hyperkalemic Hypertension results from an increased expression of L-WNK1 specifically in the distal nephron.The emerging family of CULLIN3-RING ubiquitin ligases (CRL3s): cellular functions and disease implications.Cullin-3 mutation causes arterial stiffness and hypertension through a vascular smooth muscle mechanism.Mineralocorticoid receptor phosphorylation regulates ligand binding and renal response to volume depletion and hyperkalemiaWNK signalling pathways in blood pressure regulationElectroneutral absorption of NaCl by the aldosterone-sensitive distal nephron: implication for normal electrolytes homeostasis and blood pressure regulation.Regulation of Potassium Homeostasis
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P2860
Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension
description
2013 nî lūn-bûn
@nan
2013 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի մարտին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension
@ast
Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension
@en
Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension
@en-gb
Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension
@nl
type
label
Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension
@ast
Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension
@en
Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension
@en-gb
Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension
@nl
prefLabel
Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension
@ast
Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension
@en
Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension
@en-gb
Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension
@nl
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P921
P3181
P1433
P1476
Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension
@en
P2093
Eisei Sohara
Eriko Kikuchi
Hiroshi Matsuo
Hiroyuki Kawaguchi
Kiyoshi Isobe
Koichiro Susa
Mai Wakabayashi
Motoko Chiga
Naohiro Nomura
Sei Sasaki
P304
P3181
P356
10.1016/J.CELREP.2013.02.024
P407
P577
2013-03-28T00:00:00Z