Identification of small subunits of mammalian serine palmitoyltransferase that confer distinct acyl-CoA substrate specificities
about
Mutations in the SPTLC2 subunit of serine palmitoyltransferase cause hereditary sensory and autonomic neuropathy type IThe SPTLC3 subunit of serine palmitoyltransferase generates short chain sphingoid bases1-Deoxysphingolipids Encountered Exogenously and Made de Novo: Dangerous Mysteries inside an EnigmaInhibition of the PLP-dependent enzyme serine palmitoyltransferase by cycloserine: evidence for a novel decarboxylative mechanism of inactivationAutophagy regulates sphingolipid levels in the liverElevation of 20-carbon long chain bases due to a mutation in serine palmitoyltransferase small subunit b results in neurodegenerationLipidomics for studying metabolismHSAN1 mutations in serine palmitoyltransferase reveal a close structure-function-phenotype relationship.The Concise Guide to PHARMACOLOGY 2013/14: enzymes.Myeloid cell-specific serine palmitoyltransferase subunit 2 haploinsufficiency reduces murine atherosclerosis.Remodeling adipose tissue through in silico modulation of fat storage for the prevention of type 2 diabetes.A disease-causing mutation in the active site of serine palmitoyltransferase causes catalytic promiscuityThe representation of protein complexes in the Protein Ontology (PRO).Role of a conserved arginine residue during catalysis in serine palmitoyltransferase.Reducing plasma membrane sphingomyelin increases insulin sensitivity.An update on sphingosine-1-phosphate and other sphingolipid mediators.Expression of the ORMDLS, modulators of serine palmitoyltransferase, is regulated by sphingolipids in mammalian cellsA method for visualization of "omic" datasets for sphingolipid metabolism to predict potentially interesting differences.Novel HSAN1 mutation in serine palmitoyltransferase resides at a putative phosphorylation site that is involved in regulating substrate specificityFunctional asymmetry for the active sites of linked 5-aminolevulinate synthase and 8-amino-7-oxononanoate synthase.Many ceramides.Plasma 1-deoxysphingolipids are predictive biomarkers for type 2 diabetes mellitusSphingolipid and glycosphingolipid metabolic pathways in the era of sphingolipidomics.Acyl-lipid metabolism.Identification of novel genes that regulate androgen receptor signaling and growth of androgen-deprived prostate cancer cells.Sphingolipid and ceramide homeostasis: potential therapeutic targets.Asn-150 of Murine Erythroid 5-Aminolevulinate Synthase Modulates the Catalytic Balance between the Rates of the Reversible ReactionCardiomyocyte specific deficiency of serine palmitoyltransferase subunit 2 reduces ceramide but leads to cardiac dysfunction.Myristic acid potentiates palmitic acid-induced lipotoxicity and steatohepatitis associated with lipodystrophy by sustaning de novo ceramide synthesis.Topological and functional characterization of the ssSPTs, small activating subunits of serine palmitoyltransferaseMyristate-derived d16:0 sphingolipids constitute a cardiac sphingolipid pool with distinct synthetic routes and functional properties.Cell polarity factor Par3 binds SPTLC1 and modulates monocyte serine palmitoyltransferase activity and chemotaxis.The interplay between bioactive sphingolipids and steroid hormones.PLP-dependent enzymes as entry and exit gates of sphingolipid metabolism.Nuclear sphingolipid metabolism.Structural, mechanistic and regulatory studies of serine palmitoyltransferase.The role of sphingolipids in drug metabolism and transport.Sphingolipid metabolism and neutral sphingomyelinases.Glycosphingolipids: synthesis and functions.Sphingolipid metabolism and interorganellar transport: localization of sphingolipid enzymes and lipid transfer proteins.
P2860
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P248
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P2860
Identification of small subunits of mammalian serine palmitoyltransferase that confer distinct acyl-CoA substrate specificities
description
2009 nî lūn-bûn
@nan
2009 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Identification of small subuni ...... yl-CoA substrate specificities
@ast
Identification of small subuni ...... yl-CoA substrate specificities
@en
Identification of small subuni ...... yl-CoA substrate specificities
@en-gb
Identification of small subuni ...... yl-CoA substrate specificities
@nl
type
label
Identification of small subuni ...... yl-CoA substrate specificities
@ast
Identification of small subuni ...... yl-CoA substrate specificities
@en
Identification of small subuni ...... yl-CoA substrate specificities
@en-gb
Identification of small subuni ...... yl-CoA substrate specificities
@nl
prefLabel
Identification of small subuni ...... yl-CoA substrate specificities
@ast
Identification of small subuni ...... yl-CoA substrate specificities
@en
Identification of small subuni ...... yl-CoA substrate specificities
@en-gb
Identification of small subuni ...... yl-CoA substrate specificities
@nl
P2093
P2860
P921
P3181
P356
P1476
Identification of small subuni ...... yl-CoA substrate specificities
@en
P2093
Florian Eichler
Gongshe Han
Jeffrey M Harmon
Kenneth Gable
Prasun Moitra
Sita D Gupta
Somashekarappa Niranjanakumari
Teresa M Dunn
P2860
P304
P3181
P356
10.1073/PNAS.0811269106
P407
P577
2009-05-19T00:00:00Z