Glucokinase mutations associated with non-insulin-dependent (type 2) diabetes mellitus have decreased enzymatic activity: implications for structure/function relationships
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Complexity of type 2 diabetes mellitus data sets emerging from nutrigenomic research: a case for dimensionality reduction?Evidence for haploinsufficiency of the human HNF1alpha gene revealed by functional characterization of MODY3-associated mutationsInsulin secretory abnormalities in subjects with hyperglycemia due to glucokinase mutationsImpaired hepatic glycogen synthesis in glucokinase-deficient (MODY-2) subjectsHomotropic allosteric regulation in monomeric mammalian glucokinaseCoexpression of glucose transporters and glucokinase in Xenopus oocytes indicates that both glucose transport and phosphorylation determine glucose utilizationNuclear import of hepatic glucokinase depends upon glucokinase regulatory protein, whereas export is due to a nuclear export signal sequence in glucokinaseAnimal model for maturity-onset diabetes of the young generated by disruption of the mouse glucokinase geneMice mutant for glucokinase regulatory protein exhibit decreased liver glucokinase: a sequestration mechanism in metabolic regulationPhosphatase-coupled universal kinase assay and kinetics for first-order-rate coupling reactionComparative genetic analysis: the utility of mouse genetic systems for studying human monogenic disease.Lys169 of human glucokinase is a determinant for glucose phosphorylation: implication for the atomic mechanism of glucokinase catalysis.Genetic epidemiology of diabetes.A phospho-BAD BH3 helix activates glucokinase by a mechanism distinct from that of allosteric activatorsDeletion of the donor splice site of intron 4 in the glucokinase gene causes maturity-onset diabetes of the youngMetabolic signals trigger glucose-induced inactivation of maltose permease in SaccharomycesIn situ glucose uptake and glucokinase activity of pancreatic islets in diabetic and obese rodents.Physiological and pharmacological regulation of insulin release: insights offered through exploitation of insulin-secreting cell lines.Assessment of the effects of insulin secretagogues in humans.Glucokinase (GCK) mutations and their characterization in MODY2 children of southern Italy.Contrasting molecular population genetics of four hexokinases in Drosophila melanogaster, D. simulans and D. yakuba.Genetic approaches to the molecular understanding of type 2 diabetes.GCK-MODY (MODY 2) Caused by a Novel p.Phe330Ser Mutation.Roles of Vitamin A Metabolism in the Development of Hepatic Insulin Resistance.iPSC-derived β cells model diabetes due to glucokinase deficiencyCharacterization of the MODY3 phenotype. Early-onset diabetes caused by an insulin secretion defect.Variable effects of maturity-onset-diabetes-of-youth (MODY)-associated glucokinase mutations on substrate interactions and stability of the enzyme.Human beta-cell glucokinase. Dual role of Ser-151 in catalysis and hexose affinity.Structure-function analysis of yeast hexokinase: structural requirements for triggering cAMP signalling and catabolite repression.Effect of mutations on the sensitivity of human beta-cell glucokinase to liver regulatory protein.Novel approaches to treating type 2 diabetes.A model of phosphofructokinase and glycolytic oscillations in the pancreatic beta-cell.Glucokinase as pancreatic beta cell glucose sensor and diabetes gene.Mammalian glucokinase and its gene.Cell-biological assessment of human glucokinase mutants causing maturity-onset diabetes of the young type 2 (MODY-2) or glucokinase-linked hyperinsulinaemia (GK-HI).Non-insulin-dependent diabetes mellitus--a collision between thrifty genes and an affluent society.Structural Variations of Human Glucokinase Glu256Lys in MODY2 Condition Using Molecular Dynamics Study.Glucokinase activity in isolated islets from obese fa/fa Zucker rats.A glucokinase gene mutation in a young boy with diabetes mellitus, hyperinsulinemia, and insulin resistanceHexokinase PII: structural analysis and glucose signalling in the yeast Saccharomyces cerevisiae.
P2860
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P2860
Glucokinase mutations associated with non-insulin-dependent (type 2) diabetes mellitus have decreased enzymatic activity: implications for structure/function relationships
description
1993 nî lūn-bûn
@nan
1993 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի մարտին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
Glucokinase mutations associat ...... ructure/function relationships
@ast
Glucokinase mutations associat ...... ructure/function relationships
@en
Glucokinase mutations associat ...... ructure/function relationships
@en-gb
Glucokinase mutations associat ...... ructure/function relationships
@nl
type
label
Glucokinase mutations associat ...... ructure/function relationships
@ast
Glucokinase mutations associat ...... ructure/function relationships
@en
Glucokinase mutations associat ...... ructure/function relationships
@en-gb
Glucokinase mutations associat ...... ructure/function relationships
@nl
prefLabel
Glucokinase mutations associat ...... ructure/function relationships
@ast
Glucokinase mutations associat ...... ructure/function relationships
@en
Glucokinase mutations associat ...... ructure/function relationships
@en-gb
Glucokinase mutations associat ...... ructure/function relationships
@nl
P2093
P2860
P921
P356
P1476
Glucokinase mutations associat ...... ructure/function relationships
@en
P2093
M Gidh-Jain
P2860
P304
P356
10.1073/PNAS.90.5.1932
P407
P577
1993-03-01T00:00:00Z