The selectivity of receptor tyrosine kinase signaling is controlled by a secondary SH2 domain binding site
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Asymmetric receptor contact is required for tyrosine autophosphorylation of fibroblast growth factor receptor in living cellsGrb14 inhibits FGF receptor signaling through the regulation of PLCγ recruitment and activationThe development and application of a quantitative peptide microarray based approach to protein interaction domain specificity spaceCell signaling by receptor tyrosine kinasesEvolution of SH2 domains and phosphotyrosine signalling networksThe use of polyoxometalates in protein crystallography – An attempt to widen a well-known bottleneckUnusual binding interactions in PDZ domain crystal structures help explain binding mechanismsA potent and highly specific FN3 monobody inhibitor of the Abl SH2 domainNoncanonical Tandem SH2 Enables Interaction of Elongation Factor Spt6 with RNA Polymerase IIStructural Basis for the Interaction between the Growth Factor-binding Protein GRB10 and the E3 Ubiquitin Ligase NEDD4Structure of Lipid Kinase p110β/p85β Elucidates an Unusual SH2-Domain-Mediated Inhibitory MechanismTwo Closely Spaced Tyrosines Regulate NFAT Signaling in B Cells via Syk Association with VavStructural and Functional Integration of the PLCγ Interaction Domains Critical for Regulatory Mechanisms and Signaling DeregulationStructural Mimicry of A-Loop Tyrosine Phosphorylation by a Pathogenic FGF Receptor 3 MutationFGFR1 Kinase Inhibitors: Close Regioisomers Adopt Divergent Binding Modes and Display Distinct Biophysical SignaturesThe phospholipase C isozymes and their regulationThe language of SH2 domain interactions defines phosphotyrosine-mediated signal transductionHigh-throughput analysis of peptide-binding modulesIdentifying three-dimensional structures of autophosphorylation complexes in crystals of protein kinasesSH2 Domains Recognize Contextual Peptide Sequence Information to Determine SelectivityCompetition between Grb2 and Plcγ1 for FGFR2 regulates basal phospholipase activity and invasion.Hen egg-white lysozyme crystallisation: protein stacking and structure stability enhanced by a Tellurium(VI)-centred polyoxotungstateDisease-causing mutation in extracellular and intracellular domain of FGFR1 protein: computational approach.Identification of a new interaction mode between the Src homology 2 domain of C-terminal Src kinase (Csk) and Csk-binding protein/phosphoprotein associated with glycosphingolipid microdomains.Conformational transition of FGFR kinase activation revealed by site-specific unnatural amino acid reporter and single molecule FRET.Computational tools for the interactive exploration of proteomic and structural data.Dynamic, structural and thermodynamic basis of insulin-like growth factor 1 kinase allostery mediated by activation loop phosphorylation.Mechanism of phosphorylation-induced activation of phospholipase C-gamma isozymes.Tyrosine kinase BMX phosphorylates phosphotyrosine-primed motif mediating the activation of multiple receptor tyrosine kinasesCongenital hypogonadotropic hypogonadism with split hand/foot malformation: a clinical entity with a high frequency of FGFR1 mutations.Distinct sets of FGF receptors sculpt excitatory and inhibitory synaptogenesis.Fibronectin induces endothelial cell migration through β1 integrin and Src-dependent phosphorylation of fibroblast growth factor receptor-1 at tyrosines 653/654 and 766.Illuminating the molecular mechanisms of tyrosine kinase inhibitor resistance for the FGFR1 gatekeeper mutation: the Achilles' heel of targeted therapy.Perspective: Dynamics of receptor tyrosine kinase signaling complexesSerine phosphorylation of the insulin-like growth factor I (IGF-1) receptor C-terminal tail restrains kinase activity and cell growthEffects of FGFR2 kinase activation loop dynamics on catalytic activitySecondary PDZ domain-binding site on class B plexins enhances the affinity for PDZ-RhoGEFPhosphotyrosine recognition domains: the typical, the atypical and the versatile.Deciphering Phosphotyrosine-Dependent Signaling Networks in Cancer by SH2 ProfilingTime-resolved FRET reports FGFR1 dimerization and formation of a complex with its effector PLCγ1.
P2860
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P2860
The selectivity of receptor tyrosine kinase signaling is controlled by a secondary SH2 domain binding site
description
2009 nî lūn-bûn
@nan
2009 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
name
The selectivity of receptor ty ...... ondary SH2 domain binding site
@ast
The selectivity of receptor ty ...... ondary SH2 domain binding site
@en
The selectivity of receptor ty ...... ondary SH2 domain binding site
@en-gb
The selectivity of receptor ty ...... ondary SH2 domain binding site
@nl
type
label
The selectivity of receptor ty ...... ondary SH2 domain binding site
@ast
The selectivity of receptor ty ...... ondary SH2 domain binding site
@en
The selectivity of receptor ty ...... ondary SH2 domain binding site
@en-gb
The selectivity of receptor ty ...... ondary SH2 domain binding site
@nl
altLabel
The Selectivity of Receptor Ty ...... ondary SH2 Domain Binding Site
@en
prefLabel
The selectivity of receptor ty ...... ondary SH2 domain binding site
@ast
The selectivity of receptor ty ...... ondary SH2 domain binding site
@en
The selectivity of receptor ty ...... ondary SH2 domain binding site
@en-gb
The selectivity of receptor ty ...... ondary SH2 domain binding site
@nl
P2093
P2860
P1433
P1476
The selectivity of receptor ty ...... ondary SH2 domain binding site
@en
P2093
Erin Denise Lew
Francisco Tomé
Jae Hyun Bae
Satoru Yuzawa
P2860
P304
P356
10.1016/J.CELL.2009.05.028
P407
P577
2009-08-07T00:00:00Z