The SRY high-mobility-group box recognizes DNA by partial intercalation in the minor groove: a topological mechanism of sequence specificity
about
Sexual dimorphism in diverse metazoans is regulated by a novel class of intertwined zinc fingers.Reprogramming cells with synthetic proteinsSolution structure of the HMG protein NHP6A and its interaction with DNA reveals the structural determinants for non-sequence-specific bindingHMG-D complexed to a bulge DNA: An NMR modelDeterminants of DNA binding and bending by the Saccharomyces cerevisiae high mobility group protein NHP6A that are important for its biological activities. Role of the unique N terminus and putative intercalating methionine.Solution structure of the sequence-specific HMG box of the lymphocyte transcriptional activator Sox-4Microsatellite-encoded domain in rodent Sry functions as a genetic capacitor to enable the rapid evolution of biological noveltyA Novel Missense Mutation 224G>T (R75M) in SRY Coding Region Interferes with Nuclear Import and Results in 46, XY Complete Gonadal DysgenesisInteraction of human SRY protein with DNA: a molecular dynamics study.RNA recognition by arginine-rich peptide motifs.In vitro integration of human immunodeficiency virus type 1 cDNA into targets containing protein-induced bendsA peptide interaction in the major groove of RNA resembles protein interactions in the minor groove of DNA.Structural and functional conservation of fungal MatA and human SRY sex-determining proteinsStructure-function relationships in human testis-determining factor SRY: an aromatic buttress underlies the specific DNA-bending surface of a high mobility group (HMG) box.Homology model building of the HMG-1 box structural domain.The HMG-1 box protein family: classification and functional relationships.Role of testis-specific high-mobility-group protein in transcriptional regulation of inducible nitric oxide synthase expression in the liver of endotoxic shock mice.Mammalian testis-determining factor SRY and the enigma of inherited human sex reversal: frustrated induced fit in a bent protein-DNA complex.Cisplatin-DNA adducts are molecular decoys for the ribosomal RNA transcription factor hUBF (human upstream binding factor).Imino proton exchange provides an 1H-NMR footprint of protein-DNA interactions: general strategy and application to the SRY HMG box.Inherited human sex reversal due to impaired nucleocytoplasmic trafficking of SRY defines a male transcriptional threshold.Intron-encoded endonuclease I-TevI binds as a monomer to effect sequential cleavage via conformational changes in the td homing site.A new protein domain for binding to DNA through the minor groove.Sex-reversing mutations affect the architecture of SRY-DNA complexesSry, more than testis determination?Gene mutations associated with anomalies of human gonad formation.Structure prediction of a complex between the chromosomal protein HMG-D and DNA.The role of intercalating residues in chromosomal high-mobility-group protein DNA binding, bending and specificity.The testis-specific high-mobility-group protein, a phosphorylation-dependent DNA-packaging factor of elongating and condensing spermatids.Two mutations in the HMG-box with very different structural consequences provide insights into the nature of binding to four-way junction DNAThe DNA sequence specificity of HMG boxes lies in the minor wing of the structure.HMG-D is an architecture-specific protein that preferentially binds to DNA containing the dinucleotide TG.Regulation of sexual dimorphism in mammals.Human Sex Determination at the Edge of Ambiguity: INHERITED XY SEX REVERSAL DUE TO ENHANCED UBIQUITINATION AND PROTEASOMAL DEGRADATION OF A MASTER TRANSCRIPTION FACTOR.Sex-specific gene regulation. The Doublesex DM motif is a bipartite DNA-binding domain.The SRY cantilever motif discriminates between sequence- and structure-specific DNA recognition: alanine mutagenesis of an HMG box.Human sex reversal due to impaired nuclear localization of SRY. A clinical correlation.Oxidation of a critical methionine modulates DNA binding of the Drosophila melanogaster high mobility group protein, HMG-D.The Major Architects of Chromatin: Architectural Proteins in Bacteria, Archaea and Eukaryotes
P2860
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P2860
The SRY high-mobility-group box recognizes DNA by partial intercalation in the minor groove: a topological mechanism of sequence specificity
description
1993 nî lūn-bûn
@nan
1993 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
The SRY high-mobility-group bo ...... hanism of sequence specificity
@ast
The SRY high-mobility-group bo ...... hanism of sequence specificity
@en
The SRY high-mobility-group bo ...... hanism of sequence specificity
@en-gb
The SRY high-mobility-group bo ...... hanism of sequence specificity
@nl
type
label
The SRY high-mobility-group bo ...... hanism of sequence specificity
@ast
The SRY high-mobility-group bo ...... hanism of sequence specificity
@en
The SRY high-mobility-group bo ...... hanism of sequence specificity
@en-gb
The SRY high-mobility-group bo ...... hanism of sequence specificity
@nl
prefLabel
The SRY high-mobility-group bo ...... hanism of sequence specificity
@ast
The SRY high-mobility-group bo ...... hanism of sequence specificity
@en
The SRY high-mobility-group bo ...... hanism of sequence specificity
@en-gb
The SRY high-mobility-group bo ...... hanism of sequence specificity
@nl
P2860
P356
P1476
The SRY high-mobility-group bo ...... hanism of sequence specificity
@en
P2093
P2860
P304
P356
10.1073/PNAS.90.24.11990
P407
P577
1993-12-15T00:00:00Z