A novel 160-kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family
about
Insulin stimulates PKCzeta -mediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteinsSKIP negatively regulates insulin-induced GLUT4 translocation and membrane ruffle formation.Tyrosine phosphorylation of p62(Dok) induced by cell adhesion and insulin: possible role in cell migrationAssociation of insulin receptor substrate proteins with Bcl-2 and their effects on its phosphorylation and antiapoptotic functionIRS-4 mediates protein kinase B signaling during insulin stimulation without promoting antiapoptosisInsulin receptor signaling in normal and insulin-resistant statesCrystal structure of the pleckstrin homology-phosphotyrosine binding (PH-PTB) targeting region of insulin receptor substrate 1Gab2, a new pleckstrin homology domain-containing adapter protein, acts to uncouple signaling from ERK kinase to Elk-1Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth factor-I receptor-mediated signal transductionThe COOH-terminal tyrosine phosphorylation sites on IRS-1 bind SHP-2 and negatively regulate insulin signalingSTAP-2/BKS, an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motifThe full-length isoform of the mouse pleckstrin homology domain-interacting protein (PHIP) is required for postnatal growthDynamics of protein-tyrosine phosphatases in rat adipocytesInsulin receptor substrate-3 functions as transcriptional activator in the nucleusInsulin signal transduction in rat small intestine: role of MAP kinases in expression of mucosal hydrolasesSurfing the insulin signaling webEffect of receptor phosphorylation on the binding between IRS-1 and IGF-1R as revealed by surface plasmon resonance biosensorInteraction between Brk kinase and insulin receptor substrate-4.Effect of IRS4 levels on PI 3-kinase signalling.Physical and functional interactions between STAP-2/BKS and STAT5.From preadipocyte to adipocyte: differentiation-directed signals of insulin from the cell surface to the nucleus.Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistanceThe role of G proteins in insulin signalling.Syndromes associated with insulin resistance and acanthosis nigricans.Insulin receptor substrates (IRSs) and breast tumorigenesis.Targeted gene mutations define the roles of insulin and IGF-I receptors in mouse embryonic development.Human biliverdin reductase: a member of the insulin receptor substrate family with serine/threonine/tyrosine kinase activityEvolution of the vertebrate insulin receptor substrate (Irs) gene familyNormal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetesInsulin-like growth factor I synergizes with interleukin 4 for hematopoietic cell proliferation independent of insulin receptor substrate expression.Osmotic shock inhibits insulin signaling by maintaining Akt/protein kinase B in an inactive dephosphorylated stateInsulin-like growth factor I-induced degradation of insulin receptor substrate 1 is mediated by the 26S proteasome and blocked by phosphatidylinositol 3'-kinase inhibitionAnkyrin repeat and SOCS box containing protein 4 (Asb-4) colocalizes with insulin receptor substrate 4 (IRS4) in the hypothalamic neurons and mediates IRS4 degradationInsulin receptor substrate (IRS) transduction system: distinct and overlapping signaling potential.Insulin receptor substrate polymorphisms and type 2 diabetes mellitus.Tyrosine phosphoproteomics of fibroblast growth factor signaling: a role for insulin receptor substrate-4.Protein phosphatase 4 interacts with and down-regulates insulin receptor substrate 4 following tumor necrosis factor-alpha stimulation.Genetic engineering in mice: impact on insulin signalling and action.Molecular insights into insulin action and secretion.Regulation of glucose transport in human skeletal muscle.
P2860
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P2860
A novel 160-kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family
description
1997 nî lūn-bûn
@nan
1997 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
A novel 160-kDa phosphotyrosin ...... ulin receptor substrate family
@ast
A novel 160-kDa phosphotyrosin ...... ulin receptor substrate family
@en
A novel 160-kDa phosphotyrosin ...... ulin receptor substrate family
@en-gb
A novel 160-kDa phosphotyrosin ...... ulin receptor substrate family
@nl
type
label
A novel 160-kDa phosphotyrosin ...... ulin receptor substrate family
@ast
A novel 160-kDa phosphotyrosin ...... ulin receptor substrate family
@en
A novel 160-kDa phosphotyrosin ...... ulin receptor substrate family
@en-gb
A novel 160-kDa phosphotyrosin ...... ulin receptor substrate family
@nl
prefLabel
A novel 160-kDa phosphotyrosin ...... ulin receptor substrate family
@ast
A novel 160-kDa phosphotyrosin ...... ulin receptor substrate family
@en
A novel 160-kDa phosphotyrosin ...... ulin receptor substrate family
@en-gb
A novel 160-kDa phosphotyrosin ...... ulin receptor substrate family
@nl
P2093
P921
P3181
P356
P1476
A novel 160-kDa phosphotyrosin ...... ulin receptor substrate family
@en
P2093
P304
P3181
P356
10.1074/JBC.272.34.21403
P407
P577
1997-08-22T00:00:00Z