TSPAN12 regulates retinal vascular development by promoting Norrin- but not Wnt-induced FZD4/beta-catenin signaling
about
Genetic susceptibility to advanced retinopathy of prematurity (ROP)ZNF408 is mutated in familial exudative vitreoretinopathy and is crucial for the development of zebrafish retinal vasculatureTMEM237 is mutated in individuals with a Joubert syndrome related disorder and expands the role of the TMEM family at the ciliary transition zoneThe TspanC8 subgroup of tetraspanins interacts with A disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expressionMutations in TMEM216 perturb ciliogenesis and cause Joubert, Meckel and related syndromesThe Norrin/Frizzled4 signaling pathway in retinal vascular development and diseaseNeurite Mistargeting and Inverse Order of Intraretinal Vascular Plexus Formation Precede Subretinal Vascularization in Vldlr Mutant MicePromotion of bone morphogenetic protein signaling by tetraspanins and glycosphingolipidsCritical Endothelial Regulation by LRP5 during Retinal Vascular DevelopmentMaternal xNorrin, a canonical Wnt signaling agonist and TGF-β antagonist, controls early neuroectoderm specification in XenopusTetraspanin is required for generation of reactive oxygen species by the dual oxidase system in Caenorhabditis elegansStructure and function of Norrin in assembly and activation of a Frizzled 4-Lrp5/6 complexWNT/β-Catenin Signaling in Vertebrate Eye DevelopmentFrizzled Receptors in Development and DiseaseWnt proteins.A novel signaling pathway regulates colon cancer angiogenesis through Norrin.Canonical WNT signaling components in vascular development and barrier formation.Wnt signaling pathway in retinal vascularizationNext-generation sequencing of a 40 Mb linkage interval reveals TSPAN12 mutations in patients with familial exudative vitreoretinopathy.Mutations in TSPAN12 cause autosomal-dominant familial exudative vitreoretinopathy.Norrin-induced Frizzled4 endocytosis and endo-lysosomal trafficking control retinal angiogenesis and barrier function.Novel mutations in the TSPAN12 gene in Chinese patients with familial exudative vitreoretinopathy.LRP5 regulates development of lung microvessels and alveoli through the angiopoietin-Tie2 pathwayTetraspanin TSPAN12 regulates tumor growth and metastasis and inhibits β-catenin degradation.Microdomains in the membrane landscape shape antigen-presenting cell function.Genetic screening of Wnt signaling factors in advanced retinopathy of prematurityGpr124 controls CNS angiogenesis and blood-brain barrier integrity by promoting ligand-specific canonical wnt signalingAn essential role of the cysteine-rich domain of FZD4 in Norrin/Wnt signaling and familial exudative vitreoretinopathy.Expression of the Norrie disease gene (Ndp) in developing and adult mouse eye, ear, and brain.The role of the hypoxia response in shaping retinal vascular development in the absence of Norrin/Frizzled4 signaling.TSPAN12 is a critical factor for cancer-fibroblast cell contact-mediated cancer invasionFamilial exudative vitreoretinopathy and related retinopathies.Tetraspanins as regulators of the tumour microenvironment: implications for metastasis and therapeutic strategies.Novel TSPAN12 mutations in patients with familial exudative vitreoretinopathy and their associated phenotypes.Norrin protected blood-brain barrier via frizzled-4/β-catenin pathway after subarachnoid hemorrhage in rats.Rspo1/Wnt signaling promotes angiogenesis via Vegfc/Vegfr3Tip cell-specific requirement for an atypical Gpr124- and Reck-dependent Wnt/β-catenin pathway during brain angiogenesis.NF-кB-regulated micro RNAs (miRNAs) in primary human brain cells.Common micro RNAs (miRNAs) target complement factor H (CFH) regulation in Alzheimer's disease (AD) and in age-related macular degeneration (AMD)Mutation spectrum of the FZD-4, TSPAN12 AND ZNF408 genes in Indian FEVR patients.
P2860
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P2860
TSPAN12 regulates retinal vascular development by promoting Norrin- but not Wnt-induced FZD4/beta-catenin signaling
description
2009 nî lūn-bûn
@nan
2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
TSPAN12 regulates retinal vasc ...... ed FZD4/beta-catenin signaling
@ast
TSPAN12 regulates retinal vasc ...... ed FZD4/beta-catenin signaling
@en
TSPAN12 regulates retinal vasc ...... ed FZD4/beta-catenin signaling
@en-gb
TSPAN12 regulates retinal vasc ...... ed FZD4/beta-catenin signaling
@nl
type
label
TSPAN12 regulates retinal vasc ...... ed FZD4/beta-catenin signaling
@ast
TSPAN12 regulates retinal vasc ...... ed FZD4/beta-catenin signaling
@en
TSPAN12 regulates retinal vasc ...... ed FZD4/beta-catenin signaling
@en-gb
TSPAN12 regulates retinal vasc ...... ed FZD4/beta-catenin signaling
@nl
prefLabel
TSPAN12 regulates retinal vasc ...... ed FZD4/beta-catenin signaling
@ast
TSPAN12 regulates retinal vasc ...... ed FZD4/beta-catenin signaling
@en
TSPAN12 regulates retinal vasc ...... ed FZD4/beta-catenin signaling
@en-gb
TSPAN12 regulates retinal vasc ...... ed FZD4/beta-catenin signaling
@nl
P2093
P3181
P1433
P1476
TSPAN12 regulates retinal vasc ...... ed FZD4/beta-catenin signaling
@en
P2093
Dennis S Rice
Dorothy M French
Jeremy B Burton
Mike Costa
Stacey Yang
P304
P3181
P356
10.1016/J.CELL.2009.07.048
P407
P577
2009-10-01T00:00:00Z