Structure of three tandem filamin domains reveals auto-inhibition of ligand binding
about
Cytoskeletal protein filamin A is a nucleolar protein that suppresses ribosomal RNA gene transcriptionRefilinB (FAM101B) targets filamin A to organize perinuclear actin networks and regulates nuclear shape.Structural basis of the migfilin-filamin interaction and competition with integrin beta tailsIntegrin cytoplasmic tail interactionsEvidence for the mechanosensor function of filamin in tissue development.Filamin and phospholipase C-ε are required for calcium signaling in the Caenorhabditis elegans spermathecaFilamins regulate cell spreading and initiation of cell migrationAtomic Structures of Two Novel Immunoglobulin-like Domain Pairs in the Actin Cross-linking Protein FilaminThe Structure of the N-Terminus of Kindlin-1: A Domain Important for αIIbβ3 Integrin ActivationA Novel Structural Unit in the N-terminal Region of FilaminsEvidence for multisite ligand binding and stretching of filamin by integrin and migfilinA mechanism of global shape-dependent recognition and phosphorylation of filamin by protein kinase AIdentification and characterization of multiple similar ligand-binding repeats in filamin: implication on filamin-mediated receptor clustering and cross-talkG protein-coupled receptors directly bind filamin A with high affinity and promote filamin phosphorylationThe E3 ubiquitin ligase specificity subunit ASB2beta is a novel regulator of muscle differentiation that targets filamin B to proteasomal degradationMechanical dynamics in live cells and fluorescence-based force/tension sensorsFilamin structure, function and mechanics: are altered filamin-mediated force responses associated with human disease?Transcript diversification in the nervous system: a to I RNA editing in CNS function and disease developmentMacrophage mesenchymal migration requires podosome stabilization by filamin AStructural basis of filamin A functionsNew insights into the versatile roles of platelet FlnA.Exon skipping causes atypical phenotypes associated with a loss-of-function mutation in FLNA by restoring its protein function.N-terminal strands of filamin Ig domains act as a conformational switch under biological forces.Skeletal Dysplasia Mutations Effect on Human Filamins' Structure and Mechanosensing.Cystic fibrosis transmembrane conductance regulator interacts with multiple immunoglobulin domains of filamin A.Filamins in mechanosensing and signaling.Structural and functional evaluation of C. elegans filamins FLN-1 and FLN-2.Documentation and localization of force-mediated filamin A domain perturbations in moving cells.Disease-associated mutations in the actin-binding domain of filamin B cause cytoplasmic focal accumulations correlating with disease severity.The filamins: organizers of cell structure and functionThe E3 ubiquitin ligase specificity subunit ASB2α targets filamins for proteasomal degradation by interacting with the filamin actin-binding domainAssembly of a filamin four-domain fragment and the influence of splicing variant-1 on the structure.Binding of pro-prion to filamin A: by design or an unfortunate blunderDifferential mechanical stability of filamin A rod segments.Small-angle X-ray scattering reveals compact domain-domain interactions in the N-terminal region of filamin CFlexible Structure of Peptide-Bound Filamin A Mechanosensor Domain Pair 20-21FlnA binding to PACSIN2 F-BAR domain regulates membrane tubulation in megakaryocytes and plateletsRefilin holds the cap.Induction and adaptation of chaperone-assisted selective autophagy CASA in response to resistance exercise in human skeletal muscle.Regulation of integrin-mediated adhesions.
P2860
Q24304490-914EE345-2CBF-434D-B81A-B132C45EC25BQ24308006-205E4988-2324-49EA-9E69-BB9A4E21D1A0Q24317769-028112D7-BA4A-49E9-8C6C-A6D7FEF87ACDQ26823123-2D76C5B0-9192-4951-87A0-476B4BA9ADA6Q27312558-5A7E4745-E63A-400D-BA3C-0EC16615D6BAQ27322806-00F99B34-0A4A-4F14-A706-16AC1C128056Q27335443-7A59F5EB-B359-4B56-B86A-4D11A50901B6Q27656592-6E358F4E-E741-4F2B-8A92-6C3CA37E81A9Q27657671-408ECC6A-4220-4433-97AA-CB99DC152464Q27681478-5AE87890-61DD-4F62-84BC-1F532361E101Q28116700-7B200195-7996-4EAA-8475-D95BAEC5998AQ28118373-5B7B4AFB-A6B2-4DD7-A228-E2D09A834CFEQ28119187-DB376409-A55A-413E-A8E9-7BF0A2B61EB4Q28119302-EA15A5F4-122A-4544-8384-A289546A6756Q28512761-9E837B05-02DB-456C-BBD7-C938D1E91080Q28834419-A00A9BF4-4C89-4D5A-88B0-D27234B10DAEQ30402039-9B397760-AE75-4728-9400-31F0288BB14EQ30465782-8A4BE8A5-5893-456F-8123-666A1492A18CQ30513877-7025D1BC-1880-4A19-B39D-7AE7BF8FCE25Q33308469-D0EB2455-F45F-41DB-8CD0-E28CEBF48A73Q33399945-C2B30075-9AC4-47F2-893B-DA0A5FF756A8Q33423527-2C0B3D13-473D-495D-963B-14BF2889CA36Q33583554-FDB2725D-6977-472A-AE15-81C95A5A9A4BQ33835209-47545C6C-8FCC-43F3-91A7-DF614E6D99DAQ33883521-CAAB42B4-8B17-422A-9BCA-5E2B0AF16E6FQ33900830-3FD83AED-84E0-49A5-AA2B-E9D2A80A14D5Q33974916-BEC52407-78A0-4292-A476-156F1D51C018Q34069659-3E9823BE-B115-4892-B76C-5F640EFDEC4DQ34108318-29948528-00F3-41CF-B20E-74AF8E98C7D7Q34891266-9E255C1E-E8A7-4BA9-A61D-5BD7E26B0171Q35112298-7968D922-ADBF-48EB-B1A1-CEDEBAE08626Q35128299-4959DF65-A87C-4151-B819-4A6C2CC5AF65Q35173852-E235E8EA-6848-4004-BA97-22EB471FE302Q35187627-17FEC620-74DE-4EF6-A841-685174803F98Q35268778-9291143E-A74E-48C1-8F00-BD12903ABC5CQ35760349-169EEAFA-7CC8-4E4A-81F4-8FBF07B03409Q35820380-D63264E4-C634-4E40-8C0B-39B8E57A0192Q35836216-8A2D7525-E69D-4E20-BAE7-263A769A2F01Q35852833-C5CB33BE-294F-47A4-B06C-541919515F7BQ36264774-D3552266-493C-48BD-9432-B8BF62377B68
P2860
Structure of three tandem filamin domains reveals auto-inhibition of ligand binding
description
2007 nî lūn-bûn
@nan
2007 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Structure of three tandem filamin domains reveals auto-inhibition of ligand binding
@ast
Structure of three tandem filamin domains reveals auto-inhibition of ligand binding
@en
Structure of three tandem filamin domains reveals auto-inhibition of ligand binding
@en-gb
Structure of three tandem filamin domains reveals auto-inhibition of ligand binding
@nl
type
label
Structure of three tandem filamin domains reveals auto-inhibition of ligand binding
@ast
Structure of three tandem filamin domains reveals auto-inhibition of ligand binding
@en
Structure of three tandem filamin domains reveals auto-inhibition of ligand binding
@en-gb
Structure of three tandem filamin domains reveals auto-inhibition of ligand binding
@nl
prefLabel
Structure of three tandem filamin domains reveals auto-inhibition of ligand binding
@ast
Structure of three tandem filamin domains reveals auto-inhibition of ligand binding
@en
Structure of three tandem filamin domains reveals auto-inhibition of ligand binding
@en-gb
Structure of three tandem filamin domains reveals auto-inhibition of ligand binding
@nl
P2093
P2860
P50
P3181
P356
P1433
P1476
Structure of three tandem filamin domains reveals auto-inhibition of ligand binding
@en
P2093
Iain D Campbell
Tiila Kiema
Yatish Lad
P2860
P304
P3181
P356
10.1038/SJ.EMBOJ.7601827
P407
P577
2007-08-09T00:00:00Z