Protein kinase C-theta-mediated signals enhance CD4+ T cell survival by up-regulating Bcl-xL
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The Role of PKC-θ in CD4+ T Cells and HIV Infection: To the Nucleus and Back AgainDiacylglycerol Kinases in T Cell Tolerance and Effector FunctionCish actively silences TCR signaling in CD8+ T cells to maintain tumor toleranceAn enigmatic tail of CD28 signaling.Protective Toxoplasma gondii-specific T-cell responses require T-cell-specific expression of protein kinase C-theta.Biochemical and genetic evidence for a SAP-PKC-theta interaction contributing to IL-4 regulation.SAP is required for the development of innate phenotype in H2-M3--restricted Cd8(+) T cells.Inhibition of methyltransferases results in induction of g2/m checkpoint and programmed cell death in human T-lymphotropic virus type 1-transformed cells.The emerging role of protein kinase Cθ in cytoskeletal signaling.Prognostic impact of expression of Bcl-2 and Bax genes in circulating immune cells derived from patients with head and neck carcinoma.A critical role for protein kinase C-theta-mediated T cell survival in cardiac allograft rejection.Protein kinase C theta (PKCtheta): a key player in T cell life and deathSwiprosin-1 Expression Is Up-Regulated through Protein Kinase C-θ and NF-κB Pathway in T CellsRegulation of Lipid Signaling by Diacylglycerol Kinases during T Cell Development and FunctionProtein kinase C-theta is required for efficient positive selection.Targeted knock-in mice expressing mutations of CD28 reveal an essential pathway for costimulationDifferential requirement of PKC-theta in the development and function of natural regulatory T cells.Development of nonalcoholic steatohepatitis in insulin-resistant liver-specific S503A carcinoembryonic antigen-related cell adhesion molecule 1 mutant miceThe yin and yang of protein kinase C-theta (PKCθ): a novel drug target for selective immunosuppression.PKC-θ is a drug target for prevention of T cell-mediated autoimmunity and allograft rejection.The role of CARMA1 in T cells.Novel antileukemic compound ingenol 3-angelate inhibits T cell apoptosis by activating protein kinase Ctheta.Protein kinase C-beta and -delta isoenzymes promote arachidonic acid production and proliferation of MonoMac-6 cells.PKC-ѳ is dispensable for OX40L-induced TCR-independent Treg proliferation but contributes by enabling IL-2 production from effector T-cells.Protein kinase C-θ inhibits inducible regulatory T cell differentiation via an AKT-Foxo1/3a-dependent pathway.Protein kinase C-θ promotes Th17 differentiation via upregulation of Stat3.Intervention of PKC-θ as an immunosuppressive regimen.The SLAM-associated protein signaling pathway is required for development of CD4+ T cells selected by homotypic thymocyte interaction.Loss of protein kinase C theta, Bcl10, or Malt1 selectively impairs proliferation and NF-kappa B activation in the CD4+ T cell subset.Effects of the novel protein kinase C inhibitor AEB071 (Sotrastaurin) on rat cardiac allograft survival using single agent treatment or combination therapy with cyclosporine, everolimus or FTY720.B cells assist allograft rejection in the deficiency of protein kinase c-theta.The deficiency of Gαq leads to enhanced T-cell survival.c-Rel phenocopies PKCtheta but not Bcl-10 in regulating CD8+ T-cell activation versus tolerance.
P2860
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P2860
Protein kinase C-theta-mediated signals enhance CD4+ T cell survival by up-regulating Bcl-xL
description
2006 nî lūn-bûn
@nan
2006 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Protein kinase C-theta-mediate ...... rvival by up-regulating Bcl-xL
@ast
Protein kinase C-theta-mediate ...... rvival by up-regulating Bcl-xL
@en
Protein kinase C-theta-mediate ...... rvival by up-regulating Bcl-xL
@en-gb
Protein kinase C-theta-mediate ...... rvival by up-regulating Bcl-xL
@nl
type
label
Protein kinase C-theta-mediate ...... rvival by up-regulating Bcl-xL
@ast
Protein kinase C-theta-mediate ...... rvival by up-regulating Bcl-xL
@en
Protein kinase C-theta-mediate ...... rvival by up-regulating Bcl-xL
@en-gb
Protein kinase C-theta-mediate ...... rvival by up-regulating Bcl-xL
@nl
prefLabel
Protein kinase C-theta-mediate ...... rvival by up-regulating Bcl-xL
@ast
Protein kinase C-theta-mediate ...... rvival by up-regulating Bcl-xL
@en
Protein kinase C-theta-mediate ...... rvival by up-regulating Bcl-xL
@en-gb
Protein kinase C-theta-mediate ...... rvival by up-regulating Bcl-xL
@nl
P2093
P3181
P1476
Protein kinase C-theta-mediate ...... rvival by up-regulating Bcl-xL
@en
P2093
Santhakumar Manicassamy
Sonal Gupta
Zhaofeng Huang
Zuoming Sun
P304
P3181
P356
10.4049/JIMMUNOL.176.11.6709
P407
P577
2006-06-01T00:00:00Z