Ubiquilin-2 (UBQLN2) binds with high affinity to the C-terminal region of TDP-43 and modulates TDP-43 levels in H4 cells: characterization of inhibition by nucleic acids and 4-aminoquinolines
about
ALS-linked mutations in ubiquilin-2 or hnRNPA1 reduce interaction between ubiquilin-2 and hnRNPA1A high-content screen identifies novel compounds that inhibit stress-induced TDP-43 cellular aggregation and associated cytotoxicity.Ubiquilin-2 drives NF-κB activity and cytosolic TDP-43 aggregation in neuronal cells.Protein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities?TDP-43 or FUS-induced misfolded human wild-type SOD1 can propagate intercellularly in a prion-like fashionMotor neuron disease, TDP-43 pathology, and memory deficits in mice expressing ALS-FTD-linked UBQLN2 mutations.Targeting TDP-43 in neurodegenerative diseases.Viral expression of ALS-linked ubiquilin-2 mutants causes inclusion pathology and behavioral deficits in mice.Mutant UBQLN2 promotes toxicity by modulating intrinsic self-assembly
P2860
Q28115018-7A50F360-5C29-4278-BC57-82F946636A6EQ30570770-D458B24B-44C6-45CF-99C1-D951662888B8Q30671325-2DAC7650-C64B-4623-A10C-7FE7A4B6A70EQ33621868-4443ADAA-F209-478B-BAA2-756AA5C3128FQ36633172-93C0C003-1C24-420A-9CAF-73917ADC435BQ37451158-A3425772-51FA-4A75-9FCA-FF7CED791E71Q38197689-A4EFDA89-7099-4937-9D9E-FF9FB984939AQ40760984-916BA0DF-3E6A-4119-AF37-55F6BCE40EEAQ58594611-53D4F01F-C8A7-4FA8-A69D-53C7B2B9EA56
P2860
Ubiquilin-2 (UBQLN2) binds with high affinity to the C-terminal region of TDP-43 and modulates TDP-43 levels in H4 cells: characterization of inhibition by nucleic acids and 4-aminoquinolines
description
2013 nî lūn-bûn
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2013 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2013年の論文
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2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Ubiquilin-2 (UBQLN2) binds wit ...... ic acids and 4-aminoquinolines
@ast
Ubiquilin-2 (UBQLN2) binds wit ...... ic acids and 4-aminoquinolines
@en
Ubiquilin-2 (UBQLN2) binds wit ...... ic acids and 4-aminoquinolines
@en-gb
Ubiquilin-2 (UBQLN2) binds wit ...... ic acids and 4-aminoquinolines
@nl
type
label
Ubiquilin-2 (UBQLN2) binds wit ...... ic acids and 4-aminoquinolines
@ast
Ubiquilin-2 (UBQLN2) binds wit ...... ic acids and 4-aminoquinolines
@en
Ubiquilin-2 (UBQLN2) binds wit ...... ic acids and 4-aminoquinolines
@en-gb
Ubiquilin-2 (UBQLN2) binds wit ...... ic acids and 4-aminoquinolines
@nl
prefLabel
Ubiquilin-2 (UBQLN2) binds wit ...... ic acids and 4-aminoquinolines
@ast
Ubiquilin-2 (UBQLN2) binds wit ...... ic acids and 4-aminoquinolines
@en
Ubiquilin-2 (UBQLN2) binds wit ...... ic acids and 4-aminoquinolines
@en-gb
Ubiquilin-2 (UBQLN2) binds wit ...... ic acids and 4-aminoquinolines
@nl
P2860
P1476
Ubiquilin-2 (UBQLN2) binds wit ...... ic acids and 4-aminoquinolines
@en
P2093
Allen B Reitz
Joel A Cassel
P2860
P304
P356
10.1016/J.BBAPAP.2013.03.020
P407
P577
2013-06-01T00:00:00Z