Urokinase-induced signaling in human vascular smooth muscle cells is mediated by PDGFR-beta - Wikidata - awgldk - TriplyDB

Urokinase-induced signaling in human vascular smooth muscle cells is mediated by PDGFR-beta

Urokinase-induced signaling in human vascular smooth muscle cells is mediated by PDGFR-beta

http://www.wikidata.org/entity/Q24529131

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RNA interference-directed knockdown of urokinase plasminogen activator and urokinase plasminogen activator receptor inhibits prostate cancer cell invasion, survival, and tumorigenicity in vivo Urokinase receptor and resistance to targeted anticancer agents VEGF-initiated angiogenesis and the uPA/uPAR system Plasminogen Activator System and Breast Cancer: Potential Role in Therapy Decision Making and Precision Medicine uPAR induces epithelial-mesenchymal transition in hypoxic breast cancer cells.Stat1 nuclear translocation by nucleolin upon monocyte differentiation.Downregulation of uPAR and cathepsin B induces apoptosis via regulation of Bcl-2 and Bax and inhibition of the PI3K/Akt pathway in gliomas.Probing binding and cellular activity of pyrrolidinone and piperidinone small molecules targeting the urokinase receptor.Epigenetic upregulation of urokinase plasminogen activator promotes the tropism of mesenchymal stem cells for tumor cells.Regulation of arterial remodeling and angiogenesis by urokinase-type plasminogen activator.Pulmonary veins in the normal lung and pulmonary hypertension due to left heart disease.Urokinase and its receptors in chronic kidney disease.Targeting multiple conformations leads to small molecule inhibitors of the uPAR·uPA protein-protein interaction that block cancer cell invasion uPA and PAI-1 as biomarkers in breast cancer: validated for clinical use in level-of-evidence-1 studies.Virtual screening targeting the urokinase receptor, biochemical and cell-based studies, synthesis, pharmacokinetic characterization, and effect on breast tumor metastasis Urokinase receptor cleavage: a crucial step in fibroblast-to-myofibroblast differentiation.RNA interference-mediated targeting of urokinase plasminogen activator receptor and matrix metalloproteinase-9 gene expression in the IOMM-lee malignant meningioma cell line inhibits tumor growth, tumor cell invasion and angiogenesis.Urokinase-type plasminogen activator receptor interaction with β1 integrin is required for platelet-derived growth factor-AB-induced human mesenchymal stem/stromal cell migration.Design, synthesis, biochemical studies, cellular characterization, and structure-based computational studies of small molecules targeting the urokinase receptor.Structural basis of interaction between urokinase-type plasminogen activator and its receptor Urokinase receptor mediates osteogenic differentiation of mesenchymal stem cells and vascular calcification via the complement C5a receptor.Development of novel therapeutics targeting the urokinase plasminogen activator receptor (uPAR) and their translation toward the clinic.Dynamics of PDGFRβ expression in different cell types after brain injury.The urokinase receptor promotes cancer metastasis independently of urokinase-type plasminogen activator in mice A region in urokinase plasminogen receptor domain III controlling a functional association with alpha5beta1 integrin and tumor growth.The uPA/uPAR system regulates the bioavailability of PDGF-DD: implications for tumour growth.Urokinase-receptor-mediated phenotypic changes in vascular smooth muscle cells require the involvement of membrane rafts.Urokinase activates macrophage PON2 gene transcription via the PI3K/ROS/MEK/SREBP-2 signalling cascade mediated by the PDGFR-beta.D2A sequence of the urokinase receptor induces cell growth through αvβ3 integrin and EGFR.The interaction of uPAR with VEGFR2 promotes VEGF-induced angiogenesis.Effects of platelet-derived growth factor isoforms on plasminogen activation by periodontal ligament and gingival fibroblasts.

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P2860

Urokinase-induced signaling in human vascular smooth muscle cells is mediated by PDGFR-beta

http://www.wikidata.org/entity/Q24529131

description

2005 nî lūn-bûn

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2005 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2005 թվականի մայիսին հրատարակված գիտական հոդված

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2005年の論文

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SJ.EMBOJ.7600669

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The EMBO Journal

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Inna Dumler

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Julia Kiyan

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Roman Kiyan

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P2860

Mechanism of action and in vivo role of platelet-derived growth factor

Direct binding of occupied urokinase receptor (uPAR) to LDL receptor-related protein is required for endocytosis of uPAR and regulation of cell surface urokinase activity

The receptor for urokinase type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexes

Urokinase induces activation and formation of Stat4 and Stat1-Stat2 complexes in human vascular smooth muscle cells

Regulation of proteolytic enzymes and inhibitors in two smooth muscle cell phenotypes

Urokinase plasminogen activator induces smooth muscle cell migration: key role of growth factor-like domain

Urokinase-induced mitogenesis is mediated by casein kinase 2 and nucleolin.

Distinct mechanisms of activation of Stat1 and Stat3 by platelet-derived growth factor receptor in a cell-free system.

The fibrinolytic receptor for urokinase activates the G protein-coupled chemotactic receptor FPRL1/LXA4R.

uPAR: a versatile signalling orchestrator.

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