Erk5 null mice display multiple extraembryonic vascular and embryonic cardiovascular defects
about
Conditional deletion of ERK5 MAP kinase in the nervous system impairs pheromone information processing and pheromone-evoked behaviorsErk5 activation elicits a vasoprotective endothelial phenotype via induction of Kruppel-like factor 4 (KLF4)An analysis of the phosphorylation and activation of extracellular-signal-regulated protein kinase 5 (ERK5) by mitogen-activated protein kinase kinase 5 (MKK5) in vitroSystematic discovery of nonobvious human disease models through orthologous phenotypesStructural mechanism for the specific assembly and activation of the extracellular signal regulated kinase 5 (ERK5) moduleActivation and function of the MAPKs and their substrates, the MAPK-activated protein kinasesKnockout of ERK5 causes multiple defects in placental and embryonic developmentX-ray Crystal Structure of ERK5 (MAPK7) in Complex with a Specific InhibitorERK5 Mediated Signalling in Diabetic RetinopathyDifferential role of MEK5alpha and MEK5beta in BMK1/ERK5 activationRegulation of phosphodiesterase 3 and inducible cAMP early repressor in the heartMitogen-activated protein kinase signaling in the heart: angels versus demons in a heart-breaking tale.Targeted deletion of mek5 causes early embryonic death and defects in the extracellular signal-regulated kinase 5/myocyte enhancer factor 2 cell survival pathwayERK5 MAPK regulates embryonic angiogenesis and acts as a hypoxia-sensitive repressor of vascular endothelial growth factor expressionIntegration of protein kinases mTOR and extracellular signal-regulated kinase 5 in regulating nucleocytoplasmic localization of NFATc4Erk5 Is a Key Regulator of Naive-Primed Transition and Embryonic Stem Cell IdentityCanonical and kinase activity-independent mechanisms for extracellular signal-regulated kinase 5 (ERK5) nuclear translocation require dissociation of Hsp90 from the ERK5-Cdc37 complexAn ERK-p38 subnetwork coordinates host cell apoptosis and necrosis during coxsackievirus B3 infection.Extracellular Signal-Regulated Kinase 5 is Required for Low-Concentration H2O2-Induced Angiogenesis of Human Umbilical Vein Endothelial Cells.DCLK1 is correlated with MET and ERK5 expression, and associated with prognosis in malignant pleural mesothelioma.Natural angiogenesis inhibitor signals through Erk5 activation of peroxisome proliferator-activated receptor gamma (PPARgamma).Mitogen-activated protein kinase phosphatase-1 promotes neovascularization and angiogenic gene expressionMEK and the inhibitors: from bench to bedside.The dual-specificity protein phosphatase DUSP9/MKP-4 is essential for placental function but is not required for normal embryonic developmentIdentification of Thymosin β4 as an effector of Hand1-mediated vascular development.14-3-3beta binds to big mitogen-activated protein kinase 1 (BMK1/ERK5) and regulates BMK1 function.Crosstalk between mitogen-activated protein kinases and mitochondria in cardiac diseases: therapeutic perspectivesExtracellular signal-regulated kinase (ERK) 5 is necessary and sufficient to specify cortical neuronal fate.Physiological, pharmacological and toxicological considerations of drug-induced structural cardiac injuryMolecular profiles of mitogen activated protein kinase signaling pathways in orofacial development.ERK5 activation of MEF2-mediated gene expression plays a critical role in BDNF-promoted survival of developing but not mature cortical neurons.ERK5 pathway regulates transcription factors important for monocytic differentiation of human myeloid leukemia cells.Lipopolysaccharide induces cytokine production and decreases extravillous trophoblast invasion through a mitogen-activated protein kinase-mediated pathway: possible mechanisms of first trimester placental dysfunctionIdentification and validation of dysregulated MAPK7 (ERK5) as a novel oncogenic target in squamous cell lung and esophageal carcinomaLaminar flow activation of ERK5 leads to cytoprotective effect via CHIP-mediated p53 ubiquitination in endothelial cellsLack of endothelial cell survivin causes embryonic defects in angiogenesis, cardiogenesis, and neural tube closure.Biological Relevance and Therapeutic Potential of the Hypusine Modification System.Targeted deletion of ERK5 MAP kinase in the developing nervous system impairs development of GABAergic interneurons in the main olfactory bulb and behavioral discrimination between structurally similar odorants.Effects of Wenyangzhenshuai Granule on ERK1/2 and ERK5 activity in the myocardial tissue in a rabbit model of adriamycin-induced chronic heart failure.Tie1 deficiency induces endothelial-mesenchymal transition.
P2860
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P2860
Erk5 null mice display multiple extraembryonic vascular and embryonic cardiovascular defects
description
2002 nî lūn-bûn
@nan
2002 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Erk5 null mice display multipl ...... bryonic cardiovascular defects
@ast
Erk5 null mice display multipl ...... bryonic cardiovascular defects
@en
Erk5 null mice display multipl ...... bryonic cardiovascular defects
@en-gb
Erk5 null mice display multipl ...... bryonic cardiovascular defects
@nl
type
label
Erk5 null mice display multipl ...... bryonic cardiovascular defects
@ast
Erk5 null mice display multipl ...... bryonic cardiovascular defects
@en
Erk5 null mice display multipl ...... bryonic cardiovascular defects
@en-gb
Erk5 null mice display multipl ...... bryonic cardiovascular defects
@nl
prefLabel
Erk5 null mice display multipl ...... bryonic cardiovascular defects
@ast
Erk5 null mice display multipl ...... bryonic cardiovascular defects
@en
Erk5 null mice display multipl ...... bryonic cardiovascular defects
@en-gb
Erk5 null mice display multipl ...... bryonic cardiovascular defects
@nl
P2093
P2860
P3181
P356
P1476
Erk5 null mice display multipl ...... bryonic cardiovascular defects
@en
P2093
Christopher P Regan
Diane M Boucher
Keisuke Kuida
Michael S Su
Stephen Spatz
P2860
P304
P3181
P356
10.1073/PNAS.142293999
P407
P577
2002-07-09T00:00:00Z