Interaction of dihydrofolate reductase with methotrexate: ensemble and single-molecule kinetics. - Wikidata - awgldk - TriplyDB

Interaction of dihydrofolate reductase with methotrexate: ensemble and single-molecule kinetics.

Interaction of dihydrofolate reductase with methotrexate: ensemble and single-molecule kinetics.

http://www.wikidata.org/entity/Q24536066

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Molecular targets in arthritis and recent trends in nanotherapy Review article: dermatological complications of immunosuppressive and anti-TNF therapy in inflammatory bowel disease Shedding light on protein folding, structural and functional dynamics by single molecule studies Probing the Electrostatics of Active Site Microenvironments along the Catalytic Cycle for Escherichia coli Dihydrofolate Reductase Targeting protein function: the expanding toolkit for conditional disruption Precision targeted therapy of ovarian cancer Histidine hydrogen-deuterium exchange mass spectrometry for probing the microenvironment of histidine residues in dihydrofolate reductase Generation of a luciferase-based reporter for CHH and CG DNA methylation in Arabidopsis thaliana Controlling enzyme inhibition using an expanded set of genetically encoded amino acids.Integrative analysis for identifying joint modular patterns of gene-expression and drug-response data.Simultaneous detection of intracellular target and off-target binding of small molecule cancer drugs at nanomolar concentrations.Experimental validation of FINDSITE(comb) virtual ligand screening results for eight proteins yields novel nanomolar and micromolar binders.Update 1 of: Tunneling and dynamics in enzymatic hydride transfer.Assembly of the bacteriophage T4 primosome: single-molecule and ensemble studies Two-state displacement by the kinesin-14 Ncd stalk A randomised double-blind placebo-controlled 12- week feasibility trial of methotrexate added to treatment as usual in early schizophrenia: study protocol for a randomised controlled trial.Neutron diffraction studies of Escherichia coli dihydrofolate reductase complexed with methotrexate.PI3K inhibition synergizes with glucocorticoids but antagonizes with methotrexate in T-cell acute lymphoblastic leukemia The role of folate metabolism in orofacial development and clefting.Development and validation of an LC-MS/MS quantitative method for endogenous deoxynucleoside triphosphates in cellular lysate.PAN-811 Blocks Chemotherapy Drug-Induced In Vitro Neurotoxicity, While Not Affecting Suppression of Cancer Cell Growth Genome-scale case-control analysis of CD4+ T-cell DNA methylation in juvenile idiopathic arthritis reveals potential targets involved in disease.Two pyrenylalanines in dihydrofolate reductase form an excimer enabling the study of protein dynamics.Detection of uracil within DNA using a sensitive labeling method for in vitro and cellular applications.Self-assembly of antibodies by chemical induction Arrested Hematopoiesis and Vascular Relaxation Defects in Mice with a Mutation in Dhfr.Single-molecule investigation of the T4 bacteriophage DNA polymerase holoenzyme: multiple pathways of holoenzyme formation.Conformational relaxation following hydride transfer plays a limiting role in dihydrofolate reductase catalysis.Single-molecule and transient kinetics investigation of the interaction of dihydrofolate reductase with NADPH and dihydrofolate.Dark Agouti rat model of chemotherapy-induced mucositis: establishment and current state of the art.ATP-dependent proteases differ substantially in their ability to unfold globular proteins Second Korean guidelines for the management of Crohn's disease.Genetic and epigenomic footprints of folate.Low dosages: new chemotherapeutic weapons on the battlefield of immune-related disease.Seeing the forest for the trees: fluorescence studies of single enzymes in the context of ensemble experiments.Inhibitors of fatty acid synthesis in prokaryotes and eukaryotes as anti-infective, anticancer and anti-obesity drugs.Folate, folic acid and 5-methyltetrahydrofolate are not the same thing.Antivitamins for Medicinal Applications.Clinical, etiological and therapeutic aspects of cerebral folate deficiency.The clinical and therapeutic uses of MDM2 and PSMA and their potential interaction in aggressive cancers.

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Interaction of dihydrofolate reductase with methotrexate: ensemble and single-molecule kinetics.

http://www.wikidata.org/entity/Q24536066

description

2002 nî lūn-bûn

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2002 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2002 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2002年の論文

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Interaction of dihydrofolate r ...... e and single-molecule kinetics

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Interaction of dihydrofolate r ...... and single-molecule kinetics.

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Interaction of dihydrofolate r ...... and single-molecule kinetics.

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Interaction of dihydrofolate r ...... e and single-molecule kinetics

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Interaction of dihydrofolate r ...... and single-molecule kinetics.

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Interaction of dihydrofolate r ...... and single-molecule kinetics.

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Interaction of dihydrofolate r ...... e and single-molecule kinetics

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Interaction of dihydrofolate r ...... and single-molecule kinetics.

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Interaction of dihydrofolate r ...... and single-molecule kinetics.

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Proceedings of the National Academy of Sciences of the United States of America

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Interaction of dihydrofolate r ...... and single-molecule kinetics.

@en

P2093

Gordon G Hammes

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Lynn McCourt

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Mary Dwyer

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P T Ravi Rajagopalan

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Stephen J Benkovic

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Zhiquan Zhang

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P2860

A minimal peptide substrate in biotin holoenzyme synthetase-catalyzed biotinylation

Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence

Single-molecule enzymology

Interloop contacts modulate ligand cycling during catalysis by Escherichia coli dihydrofolate reductase.

Construction and evaluation of the kinetic scheme associated with dihydrofolate reductase from Escherichia coli.

Single-molecule fluorescence spectroscopy of enzyme conformational dynamics and cleavage mechanism.

Total internal reflection fluorescence microscopy.

Kinetics of substrate, coenzyme, and inhibitor binding to Escherichia coli dihydrofolate reductase.

High pressure NMR reveals active-site hinge motion of folate-bound Escherichia coli dihydrofolate reductase.

A Single-Molecule Study of RNA Catalysis and Folding

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13481-13486

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scholarly article

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3768038

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10.1073/PNAS.172501499

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21

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99

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2002-10-01T00:00:00Z

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11097610

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12359872

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129699

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