An embryonic/fetal beta-type globin gene repressor contains a nuclear receptor TR2/TR4 heterodimer - Wikidata - awgldk - TriplyDB

An embryonic/fetal beta-type globin gene repressor contains a nuclear receptor TR2/TR4 heterodimer

An embryonic/fetal beta-type globin gene repressor contains a nuclear receptor TR2/TR4 heterodimer

http://www.wikidata.org/entity/Q24537021

about

Developmental silencing of human zeta-globin gene expression is mediated by the transcriptional repressor RREB1 Modulation of testicular receptor 4 activity by mitogen-activated protein kinase-mediated phosphorylation The TR2 and TR4 orphan nuclear receptors repress Gata1 transcription TIP27: a novel repressor of the nuclear orphan receptor TAK1/TR4 Sox6 directly silences epsilon globin expression in definitive erythropoiesis.Fetal globin gene repressors as drug targets for molecular therapies to treat the β-globinopathies The Orphan Nuclear Receptor TR4 Is a Vitamin A-activated Nuclear Receptor Targeted inactivation of testicular nuclear orphan receptor 4 delays and disrupts late meiotic prophase and subsequent meiotic divisions of spermatogenesis Ikaros interacts with P-TEFb and cooperates with GATA-1 to enhance transcription elongation Biased, non-equivalent gene-proximal and -distal binding motifs of orphan nuclear receptor TR4 in primary human erythroid cells PGC-1 coactivator activity is required for murine erythropoiesis.A mouse tissue transcription factor atlas Control of globin gene expression during development and erythroid differentiation Minireview: Pathophysiological roles of the TR4 nuclear receptor: lessons learned from mice lacking TR4 Adult stage gamma-globin silencing is mediated by a promoter direct repeat element.Genome-wide binding of the orphan nuclear receptor TR4 suggests its general role in fundamental biological processes An international effort to cure a global health problem: A report on the 19th Hemoglobin Switching Conference.Lysine-specific demethylase 1 is a therapeutic target for fetal hemoglobin induction Role of the GATA-1/FOG-1/NuRD pathway in the expression of human beta-like globin genes.SCF induces gamma-globin gene expression by regulating downstream transcription factor COUP-TFII.Human fetal globin gene expression is regulated by LYAR.The minimal promoter plays a major role in silencing of the galago gamma-globin gene in adult erythropoiesis.Generation of mice deficient in both KLF3/BKLF and KLF8 reveals a genetic interaction and a role for these factors in embryonic globin gene silencing Compound loss of function of nuclear receptors Tr2 and Tr4 leads to induction of murine embryonic β-type globin genes Protein multifunctionality: principles and mechanisms.Recent advances in the study of testicular nuclear receptor 4 MBD2 contributes to developmental silencing of the human ε-globin gene.Transcriptional regulation of fetal to adult hemoglobin switching: new therapeutic opportunities.A chemogenomics based approach for deorphanization of testicular receptor 4: An orphan receptor of nuclear receptor superfamily.Nuclear receptors TR2 and TR4 recruit multiple epigenetic transcriptional corepressors that associate specifically with the embryonic β-type globin promoters in differentiated adult erythroid cells.Forced TR2/TR4 expression in sickle cell disease mice confers enhanced fetal hemoglobin synthesis and alleviated disease phenotypes Short-chain fatty acids induce gamma-globin gene expression by displacement of a HDAC3-NCoR repressor complex.Regulation of human fetal hemoglobin: new players, new complexities.The switch from fetal to adult hemoglobin Disruption of the Hbs1l-Myb locus causes hereditary persistence of fetal hemoglobin in a mouse model.Identification and characterization of a novel murine allele of Tmprss6.Cell signaling pathways involved in drug-mediated fetal hemoglobin induction: Strategies to treat sickle cell disease Original Research: Stable expression of miR-34a mediates fetal hemoglobin induction in K562 cells.Transcriptional mechanisms underlying hemoglobin synthesis.Transcriptional environment and chromatin architecture interplay dictates globin expression patterns of heterospecific hybrids derived from undifferentiated human embryonic stem cells or from their erythroid progeny.

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An embryonic/fetal beta-type globin gene repressor contains a nuclear receptor TR2/TR4 heterodimer

http://www.wikidata.org/entity/Q24537021

description

2002 nî lūn-bûn

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2002 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2002 թվականի հուլիսին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年论文

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name

An embryonic/fetal beta-type g ...... r receptor TR2/TR4 heterodimer

@ast

An embryonic/fetal beta-type g ...... r receptor TR2/TR4 heterodimer

@en

An embryonic/fetal beta-type g ...... r receptor TR2/TR4 heterodimer

@nl

type

label

An embryonic/fetal beta-type g ...... r receptor TR2/TR4 heterodimer

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An embryonic/fetal beta-type g ...... r receptor TR2/TR4 heterodimer

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An embryonic/fetal beta-type g ...... r receptor TR2/TR4 heterodimer

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prefLabel

An embryonic/fetal beta-type g ...... r receptor TR2/TR4 heterodimer

@ast

An embryonic/fetal beta-type g ...... r receptor TR2/TR4 heterodimer

@en

An embryonic/fetal beta-type g ...... r receptor TR2/TR4 heterodimer

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P2860

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P1433

The EMBO Journal

P1476

An embryonic/fetal beta-type g ...... r receptor TR2/TR4 heterodimer

@en

P2093

Fumiki Katsuoka

http://www.w3.org/2001/XMLSchema#string

James Douglas Engel

http://www.w3.org/2001/XMLSchema#string

Keiji Tanimoto

http://www.w3.org/2001/XMLSchema#string

Masayuki Yamamoto

http://www.w3.org/2001/XMLSchema#string

Osamu Tanabe

http://www.w3.org/2001/XMLSchema#string

Weimin Song

http://www.w3.org/2001/XMLSchema#string

P2860

Identification of a new member of the steroid receptor super-family by cloning and sequence analysis

The adenovirus major late transcription factor USF is a member of the helix-loop-helix group of regulatory proteins and binds to DNA as a dimer

Human and rat TR4 orphan receptors specify a subclass of the steroid receptor superfamily

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Stimulation of NF-E2 DNA binding by CREB-binding protein (CBP)-mediated acetylation

Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3

A novel nuclear receptor heterodimerization pathway mediated by orphan receptors TR2 and TR4

The orphan nuclear receptor TR2 suppresses a DR4 hormone response element of the mouse CRABP-I gene promoter

pEF-BOS, a powerful mammalian expression vector

Position-independent, high-level expression of the human beta-globin gene in transgenic mice

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3434-3442

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scholarly article

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10.1093/EMBOJ/CDF340

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P433

13

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P478

21

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2002-07-01T00:00:00Z

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11281556

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12093744

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P932

126089

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