snRNA interactions at 5' and 3' splice sites monitored by photoactivated crosslinking in yeast spliceosomes
about
Human homologs of yeast prp16 and prp17 reveal conservation of the mechanism for catalytic step II of pre-mRNA splicingPrp8 protein: at the heart of the spliceosomeThe canonical GU dinucleotide at the 5' splice site is recognized by p220 of the U5 snRNP within the spliceosomePolymerization defects within human telomerase are distinct from telomerase RNA and TEP1 bindingSite-specific crosslinking of mammalian U11 and u6atac to the 5' splice site of an AT-AC intronBiased exon/intron distribution of cryptic and de novo 3' splice sitesCrystal structure of the functional domain of the splicing factor Prp18Synthetic lethality of yeast slt mutations with U2 small nuclear RNA mutations suggests functional interactions between U2 and U5 snRNPs that are important for both steps of pre-mRNA splicing.Spatial organization of protein-RNA interactions in the branch site-3' splice site region during pre-mRNA splicing in yeast.Prp22, a DExH-box RNA helicase, plays two distinct roles in yeast pre-mRNA splicingInhibition of a spliceosome turnover pathway suppresses splicing defects.Pseudouridine mapping in the Saccharomyces cerevisiae spliceosomal U small nuclear RNAs (snRNAs) reveals that pseudouridine synthase pus1p exhibits a dual substrate specificity for U2 snRNA and tRNA.Prp8 retinitis pigmentosa mutants cause defects in the transition between the catalytic steps of splicing.ATP-dependent interaction of yeast U5 snRNA loop 1 with the 5' splice site.Characterization of U4 and U6 interactions with the 5' splice site using a S. cerevisiae in vitro trans-splicing systemConformational dynamics of single pre-mRNA molecules during in vitro splicing.Mutations in U5 snRNA loop 1 influence the splicing of different genes in vivo.Genetic and functional interaction of evolutionarily conserved regions of the Prp18 protein and the U5 snRNA.Functional analysis of the U5 snRNA loop 1 in the second catalytic step of yeast pre-mRNA splicing.A premature termination codon interferes with the nuclear function of an exon splicing enhancer in an open reading frame-dependent mannerConserved loop I of U5 small nuclear RNA is dispensable for both catalytic steps of pre-mRNA splicing in HeLa nuclear extracts.Proximity of the invariant loop of U5 snRNA to the second intron residue during pre-mRNA splicing.Spliceosomal snRNA modifications and their function.Rearrangements within human spliceosomes captured after exon ligation.A tertiary interaction detected in a human U2-U6 snRNA complex assembled in vitro resembles a genetically proven interaction in yeast.Identification of a U2/U6 helix la mutant that influences 3' splice site selection during nuclear pre-mRNA splicing.Genetic interactions between the 5' and 3' splice site consensus sequences and U6 snRNA during the second catalytic step of pre-mRNA splicing.The Prp18 protein stabilizes the interaction of both exons with the U5 snRNA during the second step of pre-mRNA splicingEvidence for the presence of a small U5-like RNA in active trans-spliceosomes of Trypanosoma brucei.Brr2p-mediated conformational rearrangements in the spliceosome during activation and substrate repositioningThe U1, U2 and U5 snRNAs crosslink to the 5' exon during yeast pre-mRNA splicing.The U5 RNA of trypanosomes deviates from the canonical U5 RNA: the Leptomonas collosoma U5 RNA and its coding geneThe EF-G-like GTPase Snu114p regulates spliceosome dynamics mediated by Brr2p, a DExD/H box ATPaseSpliceosomal intronogenesisProbing of the spliceosome with site-specifically derivatized 5' splice site RNA oligonucleotidesAntisense oligonucleotide binding to U5 snRNP induces a conformational change that exposes the conserved loop of U5 snRNA.Sequences upstream of the branch site are required to form helix II between U2 and U6 snRNA in a trans-splicing reaction.Role of Cwc24 in the First Catalytic Step of Splicing and Fidelity of 5' Splice Site Selection.Detection of a novel ATP-dependent cross-linked protein at the 5' splice site-U1 small nuclear RNA duplex by methylene blue-mediated photo-cross-linking.Insights into branch nucleophile positioning and activation from an orthogonal pre-mRNA splicing system in yeast.
P2860
Q24320312-9DD467E3-BDB9-487D-83E1-E209F0981B76Q24537373-45613359-8E07-49EA-919C-CF4B407F9134Q24539166-44C01929-6B09-468A-99C4-A8723CB18FC0Q24550780-C25E03DE-32CF-4F80-8A9B-674D0393490EQ24684791-023E6E78-B6C7-4C02-83B6-C17B2F0AEF14Q24817064-A7E34AB1-4C2D-4DB1-8FB2-ACA805F956CDQ27621902-79BE2D93-D29A-49F0-BE35-CAE2B5EE3A18Q27933470-F50D6C00-7B75-4E6A-A922-82BC807B24C6Q27934423-5D330DF7-3AFF-42A0-B9B0-9985EF9C85B6Q27934705-AB2ABE2A-6AF4-4E0C-9A92-8FC3464253A2Q27934735-E0F0502A-0D3A-4958-9D69-1C7EAC1B659CQ27937578-E87ACDD3-0921-4C36-9660-8BA48F554058Q27937907-278FCDE2-EDD7-48B5-8D7F-6B10E9C797FAQ28343834-A301DFEE-610C-4822-9BAF-8461965F584DQ28345350-EA5DCD83-E0A3-465B-A6B3-5C89700A6E54Q30053690-89EDD88A-8313-47B3-9BF1-BCCA3FC150E5Q31121941-A266D6B7-139B-4089-A850-5FC957926DFAQ33707671-DE64330E-1E58-4756-ADB9-91196210E012Q33888130-7A3A155A-F051-49E9-9036-195E78DF0414Q33957345-5215913F-03AB-4455-9BB4-86581B10169CQ33957723-DEC5DE64-A869-44BF-8CA3-8E58C121D530Q34080174-33683313-AFF4-46E1-ABE4-E84BAB0C62A3Q34132148-D7198CFC-C7F7-4D1F-9790-C7FEB8C35F46Q34324094-498A4485-C4FB-45B0-84A0-8135DFD75A25Q34362402-8426BE93-F628-40C2-82B9-34858EE18687Q34362884-BA35586B-026F-4BD4-AAFB-2BF7DF4F5039Q34364129-B7BC5F0E-A5CD-4152-B207-9E9DE88F98C4Q35783047-D8F1B957-EE2E-43A1-90F9-9CDCF41DE495Q35905891-18B89649-BDE1-4A72-B500-77B02D621472Q36374185-EE5B0110-6F2C-482E-B830-F14147FE550DQ36457093-6D7F1106-BFAF-4CA8-A744-2922D893BFF6Q36543243-65B8654F-2B29-4A32-B828-2AF594E5A17BQ37183473-1E977920-7843-4648-A48C-92A7C6B55274Q37183595-997A46A1-DFC2-44BC-A8DC-CD3056A5A12CQ38333283-7E719934-735C-47AB-9B84-FBC94206320EQ38343294-5AED0F16-87F3-43B7-9CB9-E24846757DA4Q38678938-E8FBA0FB-7C8B-419D-B4E2-B210D07FE645Q39085957-DC7020F9-33B3-4853-8225-76014376CE02Q39576699-28AB5726-0195-4FEA-BF06-335E5294D4B5Q39978710-1A19B8FB-E49A-49C3-834B-55B89D22C524
P2860
snRNA interactions at 5' and 3' splice sites monitored by photoactivated crosslinking in yeast spliceosomes
description
1995 nî lūn-bûn
@nan
1995 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
snRNA interactions at 5' and 3 ...... slinking in yeast spliceosomes
@ast
snRNA interactions at 5' and 3 ...... slinking in yeast spliceosomes
@en
snRNA interactions at 5' and 3 ...... slinking in yeast spliceosomes
@nl
type
label
snRNA interactions at 5' and 3 ...... slinking in yeast spliceosomes
@ast
snRNA interactions at 5' and 3 ...... slinking in yeast spliceosomes
@en
snRNA interactions at 5' and 3 ...... slinking in yeast spliceosomes
@nl
prefLabel
snRNA interactions at 5' and 3 ...... slinking in yeast spliceosomes
@ast
snRNA interactions at 5' and 3 ...... slinking in yeast spliceosomes
@en
snRNA interactions at 5' and 3 ...... slinking in yeast spliceosomes
@nl
P2093
P1433
P1476
snRNA interactions at 5' and 3 ...... slinking in yeast spliceosomes
@en
P2093
P304
P407
P577
1995-11-01T00:00:00Z