The human U4/U6 snRNP contains 60 and 90kD proteins that are structurally homologous to the yeast splicing factors Prp4p and Prp3p.
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The human U5-220kD protein (hPrp8) forms a stable RNA-free complex with several U5-specific proteins, including an RNA unwindase, a homologue of ribosomal elongation factor EF-2, and a novel WD-40 proteinProtein 61K, encoded by a gene (PRPF31) linked to autosomal dominant retinitis pigmentosa, is required for U4/U6*U5 tri-snRNP formation and pre-mRNA splicing.RNAi knockdown of hPrp31 leads to an accumulation of U4/U6 di-snRNPs in Cajal bodiesThe 20kD protein of human [U4/U6.U5] tri-snRNPs is a novel cyclophilin that forms a complex with the U4/U6-specific 60kD and 90kD proteinsHuman homologs of yeast prp16 and prp17 reveal conservation of the mechanism for catalytic step II of pre-mRNA splicingThe human U5-200kD DEXH-box protein unwinds U4/U6 RNA duplices in vitroThe 65 and 110 kDa SR-related proteins of the U4/U6.U5 tri-snRNP are essential for the assembly of mature spliceosomesHierarchical, clustered protein interactions with U4/U6 snRNA: a biochemical role for U4/U6 proteinsSMNrp is an essential pre-mRNA splicing factor required for the formation of the mature spliceosome.A cyclophilin functions in pre-mRNA splicingConserved stem II of the box C/D motif is essential for nucleolar localization and is required, along with the 15.5K protein, for the hierarchical assembly of the box C/D snoRNPIdentification and functional analysis of hPRP17, the human homologue of the PRP17/CDC40 yeast gene involved in splicing and cell cycle controlMammalian PRP4 kinase copurifies and interacts with components of both the U5 snRNP and the N-CoR deacetylase complexesThe network of protein-protein interactions within the human U4/U6.U5 tri-snRNPTri-snRNP-associated proteins interact with subunits of the TRAMP and nuclear exosome complexes, linking RNA decay and pre-mRNA splicingStructure and function of the PWI motif: a novel nucleic acid-binding domain that facilitates pre-mRNA processingDetection of snRNP assembly intermediates in Cajal bodies by fluorescence resonance energy transferA complementation method for functional analysis of mammalian genesPurification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins.A brain-derived MeCP2 complex supports a role for MeCP2 in RNA processingMutational screening of splicing factor genes in cases with autosomal dominant retinitis pigmentosaTemporal and tissue specific regulation of RP-associated splicing factor genes PRPF3, PRPF31 and PRPC8--implications in the pathogenesis of RP.Three gene-targeted mouse models of RNA splicing factor RP show late-onset RPE and retinal degeneration.Hypoxia-regulated components of the U4/U6.U5 tri-small nuclear riboprotein complex: possible role in autosomal dominant retinitis pigmentosaProbing of the spliceosome with site-specifically derivatized 5' splice site RNA oligonucleotidesSpliceosomal small nuclear ribonucleoprotein particles repeatedly cycle through Cajal bodies.Mutation in the splicing factor Hprp3p linked to retinitis pigmentosa impairs interactions within the U4/U6 snRNP complex.Assembly and dynamics of the U4/U6 di-snRNP by single-molecule FRET.
P2860
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P2860
The human U4/U6 snRNP contains 60 and 90kD proteins that are structurally homologous to the yeast splicing factors Prp4p and Prp3p.
description
1997 nî lūn-bûn
@nan
1997 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
The human U4/U6 snRNP contains ...... licing factors Prp4p and Prp3p
@nl
The human U4/U6 snRNP contains ...... icing factors Prp4p and Prp3p.
@ast
The human U4/U6 snRNP contains ...... icing factors Prp4p and Prp3p.
@en
type
label
The human U4/U6 snRNP contains ...... licing factors Prp4p and Prp3p
@nl
The human U4/U6 snRNP contains ...... icing factors Prp4p and Prp3p.
@ast
The human U4/U6 snRNP contains ...... icing factors Prp4p and Prp3p.
@en
prefLabel
The human U4/U6 snRNP contains ...... licing factors Prp4p and Prp3p
@nl
The human U4/U6 snRNP contains ...... icing factors Prp4p and Prp3p.
@ast
The human U4/U6 snRNP contains ...... icing factors Prp4p and Prp3p.
@en
P2093
P1433
P1476
The human U4/U6 snRNP contains ...... icing factors Prp4p and Prp3p.
@en
P2093
P Fabrizio
R Lührmann
P304
P407
P577
1997-08-01T00:00:00Z