Designed FHIT alleles establish that Fhit-induced apoptosis in cancer cells is limited by substrate binding - Wikidata - awgldk - TriplyDB

Designed FHIT alleles establish that Fhit-induced apoptosis in cancer cells is limited by substrate binding

Designed FHIT alleles establish that Fhit-induced apoptosis in cancer cells is limited by substrate binding

http://www.wikidata.org/entity/Q24550737

about

The histidine triad protein Hint1 triggers apoptosis independent of its enzymatic activity Fhit is a physiological target of the protein kinase Src Fhit interaction with ferredoxin reductase triggers generation of reactive oxygen species and apoptosis of cancer cells Feminizing chicks: a model for avian sex determination based on titration of Hint enzyme activity and the predicted structure of an Asw-Hint heterodimer Tumor Suppressor Genes within Common Fragile Sites Are Active Players in the DNA Damage Response Activation state-dependent interaction between Gαq subunits and the Fhit tumor suppressor.Identification of the putative tumor suppressor Nit2 as omega-amidase, an enzyme metabolically linked to glutamine and asparagine transamination.Replicative Stress and the FHIT Gene: Roles in Tumor Suppression, Genome Stability and Prevention of Carcinogenesis.Expression of fragile histidine triad in primary hepatocellular carcinoma and its relation with cell proliferation and apoptosis.Hits, Fhits and Nits: beyond enzymatic function.Fhit delocalizes annexin a4 from plasma membrane to cytosol and sensitizes lung cancer cells to paclitaxel.FHIT-proteasome degradation caused by mitogenic stimulation of the EGF receptor family in cancer cells.A knockdown with smoke model reveals FHIT as a repressor of Heme oxygenase 1 The tumor suppressor Fhit acts as a repressor of beta-catenin transcriptional activity.Characterization of the role of Fhit in suppression of DNA damage.31P NMR and genetic analysis establish hinT as the only Escherchia coli purine nucleoside phosphoramidase and as essential for growth under high salt conditions Correlation of fragile histidine triad (Fhit) protein structural features with effector interactions and biological functions Identification of the HIT-45 protein from Trypanosoma brucei as an FHIT protein/dinucleoside triphosphatase: substrate specificity studies on the recombinant and endogenous proteins.A Fhit-mimetic peptide suppresses annexin A4-mediated chemoresistance to paclitaxel in lung cancer cells.Fhit regulates invasion of lung tumor cells.The Fhit protein: an opportunity to overcome chemoresistance.Frequent silencing of fragile histidine triad gene (FHIT) in Burkitt's lymphoma is associated with aberrant hypermethylation.FHIT mRNA and protein expression in hepatocellular carcinoma.Fhit modulation of the Akt-survivin pathway in lung cancer cells: Fhit-tyrosine 114 (Y114) is essential.Small-Molecule Inhibitors of the Tumor Suppressor Fhit.New interactions between tumor suppressor Fhit protein and a nonhydrolyzable analog of its AP4 A substrate.Fhit Selective Monitoring of the Enzymatic Activity of the Tumor Suppressor Fhit

P2860

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P2860

Designed FHIT alleles establish that Fhit-induced apoptosis in cancer cells is limited by substrate binding

http://www.wikidata.org/entity/Q24550737

description

2003 nî lūn-bûn

@nan

2003 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2003年の論文

@ja

2003年論文

@yue

2003年論文

@zh-hant

2003年論文

@zh-hk

2003年論文

@zh-mo

2003年論文

@zh-tw

2003年论文

@wuu

name

Designed FHIT alleles establis ...... s limited by substrate binding

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Designed FHIT alleles establis ...... s limited by substrate binding

@en

Designed FHIT alleles establis ...... s limited by substrate binding

@nl

type

label

Designed FHIT alleles establis ...... s limited by substrate binding

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Designed FHIT alleles establis ...... s limited by substrate binding

@en

Designed FHIT alleles establis ...... s limited by substrate binding

@nl

prefLabel

Designed FHIT alleles establis ...... s limited by substrate binding

@ast

Designed FHIT alleles establis ...... s limited by substrate binding

@en

Designed FHIT alleles establis ...... s limited by substrate binding

@nl

P1433

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P2860

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P3181

P356

PNAS.0437915100

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Designed FHIT alleles establis ...... s limited by substrate binding

@en

P2093

Agnieszka Krakowiak

http://www.w3.org/2001/XMLSchema#string

Francesco Trapasso

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Helen C Pace

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Hideshi Ishii

http://www.w3.org/2001/XMLSchema#string

Jeffrey Arkles

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Kay Huebner

http://www.w3.org/2001/XMLSchema#string

Rossano Cesari

http://www.w3.org/2001/XMLSchema#string

Tamotsu Kuroki

http://www.w3.org/2001/XMLSchema#string

P2860

Genetic, biochemical, and crystallographic characterization of Fhit-substrate complexes as the active signaling form of Fhit

Structure-based analysis of catalysis and substrate definition in the HIT protein family

Fhit, a putative tumor suppressor in humans, is a dinucleoside 5',5"'-P1,P3-triphosphate hydrolase

The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers

The tumor spectrum in FHIT-deficient mice

Adenosine monophosphoramidase activity of Hint and Hnt1 supports function of Kin28, Ccl1, and Tfb3

Fhit-nucleotide specificity probed with novel fluorescent and fluorogenic substrates

Hint, Fhit, and GalT: function, structure, evolution, and mechanism of three branches of the histidine triad superfamily of nucleotide hydrolases and transferases

Muir-Torre-like syndrome in Fhit-deficient mice

A simplified system for generating recombinant adenoviruses

P304

1592-7

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P31

scholarly article

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4855731

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P356

10.1073/PNAS.0437915100

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P407

P433

4

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P478

100

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P50

Andrea Vecchione

Charles Brenner

Pawel Bieganowski

Carlo Maria Croce

P577

2003-02-18T00:00:00Z

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P5875

10910596

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P698

12574506

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P921

apoptotic process

P932

149877

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