Purification and characterization of human DNA damage checkpoint Rad complexes - Wikidata - awgldk - TriplyDB

Purification and characterization of human DNA damage checkpoint Rad complexes

Purification and characterization of human DNA damage checkpoint Rad complexes

http://www.wikidata.org/entity/Q24555188

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Multiple ATR-Chk1 pathway proteins preferentially associate with checkpoint-inducing DNA substrates Critical role for mouse Hus1 in an S-phase DNA damage cell cycle checkpoint Protein kinase Cdelta is responsible for constitutive and DNA damage-induced phosphorylation of Rad9 The human Rad9 checkpoint protein stimulates the carbamoyl phosphate synthetase activity of the multifunctional protein CAD Interaction and colocalization of Rad9/Rad1/Hus1 checkpoint complex with replication protein A in human cells Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro Characterization of functional domains in human Claspin Replication protein A-mediated recruitment and activation of Rad17 complexes Molecular modeling-based analysis of interactions in the RFC-dependent clamp-loading process Long patch base excision repair proceeds via coordinated stimulation of the multienzyme DNA repair complex Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA Biochemical characterization of DNA damage checkpoint complexes: clamp loader and clamp complexes with specificity for 5' recessed DNA The RFC clamp loader: structure and function The Mcm2-7 replicative helicase: a promising chemotherapeutic target ELG1, a yeast gene required for genome stability, forms a complex related to replication factor C Yeast Rad17/Mec3/Ddc1: a sliding clamp for the DNA damage checkpoint.Structures of the human Rad17-replication factor C and checkpoint Rad 9-1-1 complexes visualized by glycerol spray/low voltage microscopy A role of the C-terminal region of human Rad9 (hRad9) in nuclear transport of the hRad9 checkpoint complex A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein Recruitment of the cell cycle checkpoint kinase ATR to chromatin during S-phase Mechanism of proliferating cell nuclear antigen clamp opening by replication factor C The effect of Hus1 on ionizing radiation sensitivity is associated with homologous recombination repair but is independent of nonhomologous end-joining Quaternary structure of ATR and effects of ATRIP and replication protein A on its DNA binding and kinase activities ATR pathway is the primary pathway for activating G2/M checkpoint induction after re-replication.Clamp and clamp loader structures of the human checkpoint protein complexes, Rad9-1-1 and Rad17-RFC.Recruitment of DNA damage checkpoint proteins to damage in transcribed and nontranscribed sequences.Hepatitis B virus X protein induces apoptosis and cell cycle deregulation through interfering with DNA repair and checkpoint responses.Localization of hRad9 in breast cancer.TLK1B promotes repair of DSBs via its interaction with Rad9 and Asf1.Processivity factor of DNA polymerase and its expanding role in normal and translesion DNA synthesis Human ELG1 regulates the level of ubiquitinated proliferating cell nuclear antigen (PCNA) through Its interactions with PCNA and USP1.Mechanism targeted discovery of antitumor marine natural products.Preferential binding of ATR protein to UV-damaged DNA.Visualization of the physical and functional interaction between hMYH and hRad9 by Dronpa bimolecular fluorescence complementation.Genotoxin-induced Rad9-Hus1-Rad1 (9-1-1) chromatin association is an early checkpoint signaling event.The 9-1-1 checkpoint clamp stimulates DNA resection by Dna2-Sgs1 and Exo1.Genetic determinants at the interface of cancer and neurodegenerative disease.Differential hRad17 expression by histologic subtype of ovarian cancer.Phenothiazine Inhibitors of TLKs Affect Double-Strand Break Repair and DNA Damage Response Recovery and Potentiate Tumor Killing with Radiomimetic Therapy.

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Purification and characterization of human DNA damage checkpoint Rad complexes

http://www.wikidata.org/entity/Q24555188

description

2001 nî lūn-bûn

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2001 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2001 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2001年の論文

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2001年論文

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2001年論文

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2001年論文

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2001年論文

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2001年論文

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2001年论文

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name

Purification and characterization of human DNA damage checkpoint Rad complexes

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Purification and characterization of human DNA damage checkpoint Rad complexes

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Purification and characterization of human DNA damage checkpoint Rad complexes

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type

label

Purification and characterization of human DNA damage checkpoint Rad complexes

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Purification and characterization of human DNA damage checkpoint Rad complexes

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Purification and characterization of human DNA damage checkpoint Rad complexes

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Purification and characterization of human DNA damage checkpoint Rad complexes

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Purification and characterization of human DNA damage checkpoint Rad complexes

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Purification and characterization of human DNA damage checkpoint Rad complexes

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Purification and characterization of human DNA damage checkpoint Rad complexes

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P2093

J Hurwitz

http://www.w3.org/2001/XMLSchema#string

L A Lindsey-Boltz

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V P Bermudez

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P2860

Human homologs of Schizosaccharomyces pombe rad1, hus1, and rad9 form a DNA damage-responsive protein complex

The human G2 checkpoint control protein hRAD9 is a nuclear phosphoprotein that forms complexes with hRAD1 and hHUS1

HRad17 colocalizes with NHP2L1 in the nucleolus and redistributes after UV irradiation

Human DNA damage checkpoint protein hRAD9 is a 3' to 5' exonuclease

A human homologue of the Schizosaccharomyces pombe rad1+ checkpoint gene encodes an exonuclease

Identification of a human homologue of the Schizosaccharomyces pombe rad17+ checkpoint gene

Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity

cDNAs encoding the large subunit of human replication factor C

Hus1p, a conserved fission yeast checkpoint protein, interacts with Rad1p and is phosphorylated in response to DNA damage

In vitro reconstitution of human replication factor C from its five subunits

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11236-41

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scholarly article

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10.1073/PNAS.201373498

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11572977

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