Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress - Wikidata - awgldk - TriplyDB

Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress

Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress

http://www.wikidata.org/entity/Q24555749

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Molecular basis of electrophilic and oxidative defense: promises and perils of Nrf2 Role of Nrf2 in oxidative stress and toxicity Critical cysteine residues of Kelch-like ECH-associated protein 1 in arsenic sensing and suppression of nuclear factor erythroid 2-related factor 2 NRF2 cysteine residues are critical for oxidant/electrophile-sensing, Kelch-like ECH-associated protein-1-dependent ubiquitination-proteasomal degradation, and transcription activation Disruption of Nrf2 synergizes with high glucose to cause heightened myocardial oxidative stress and severe cardiomyopathy in diabetic mice New synthetic triterpenoids: potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stress Sulforaphane and Other Nutrigenomic Nrf2 Activators: Can the Clinician's Expectation Be Matched by the Reality?Effect of redox modulating NRF2 activators on chronic kidney disease Oxidative stress and nucleic acid oxidation in patients with chronic kidney disease Biochemical basis of the antidiabetic activity of oleanolic acid and related pentacyclic triterpenes Changes in Renal Function and Oxidative Status Associated with the Hypotensive Effects of Oleanolic Acid and Related Synthetic Derivatives in Experimental Animals Structure of the BTB domain of Keap1 and its interaction with the triterpenoid antagonist CDDO Cellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disorders A generalizable platform for interrogating target- and signal-specific consequences of electrophilic modifications in redox-dependent cell signaling Small molecule modulators of Keap1-Nrf2-ARE pathway as potential preventive and therapeutic agents Regulation of haeme oxygenase-1 for treatment of neuroinflammation and brain disorders Inflammation and coagulation markers and kidney function decline: the Multi-Ethnic Study of Atherosclerosis (MESA)Basic principles and emerging concepts in the redox control of transcription factors Chemical tuning enhances both potency toward nrf2 and in vitro therapeutic index of triterpenoids Implementation of a high-throughput screen for identifying small molecules to activate the Keap1-Nrf2-ARE pathway Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities Triterpenoid CDDO-methylamide improves memory and decreases amyloid plaques in a transgenic mouse model of Alzheimer's disease.In Situ Observation of Thiol Michael Addition to a Reversible Covalent Drug in a Crystalline Sponge.Neuroprotective effects of the triterpenoid, CDDO methyl amide, a potent inducer of Nrf2-mediated transcription.Potency ranking of triterpenoids as inducers of a cytoprotective enzyme and as inhibitors of a cellular inflammatory response via their electron affinity and their electrophilicity index.Nrf2: friend or foe for chemoprevention?Association of human NAD(P)H:quinone oxidoreductase 1 (NQO1) polymorphism with development of acute lung injury.Nuclear erythroid factor 2-mediated proteasome activation delays senescence in human fibroblasts.The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores Nrf2 activity and attenuates oxidative stress, inflammation, and fibrosis in rats with chronic kidney disease.Genetic or pharmacologic activation of Nrf2 signaling fails to protect against aflatoxin genotoxicity in hypersensitive GSTA3 knockout mice The triterpenoid CDDO-Me delays murine acute graft-versus-host disease with the preservation of graft-versus-tumor effects after allogeneic bone marrow transplantation.Complete protection against aflatoxin B(1)-induced liver cancer with a triterpenoid: DNA adduct dosimetry, molecular signature, and genotoxicity threshold.Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: biochemical, pharmacological and toxicological implications Proteomic analysis shows synthetic oleanane triterpenoid binds to mTOR Electrophilic tuning of the chemoprotective natural product sulforaphane.Triterpenoids CDDO-ethyl amide and CDDO-trifluoroethyl amide improve the behavioral phenotype and brain pathology in a transgenic mouse model of Huntington's disease Divergent responses of chondrocytes and endothelial cells to shear stress: cross-talk among COX-2, the phase 2 response, and apoptosis.Is there a sweet spot for Nrf2 activation in the treatment of diabetic kidney disease?The synthetic triterpenoid, CDDO-Me, modulates the proinflammatory response to in vivo lipopolysaccharide challenge.An exceptionally potent inducer of cytoprotective enzymes: elucidation of the structural features that determine inducer potency and reactivity with Keap1

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Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress

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description

2005 nî lūn-bûn

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2005 թուականի Մարտին հրատարակուած գիտական յօդուած

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2005 թվականի մարտին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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Extremely potent triterpenoid ...... xidant and inflammatory stress

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Extremely potent triterpenoid ...... xidant and inflammatory stress

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PNAS.0500815102

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Proceedings of the National Academy of Sciences of the United States of America

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Extremely potent triterpenoid ...... xidant and inflammatory stress

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Charlotte Williams

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Gordon W Gribble

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Katherine K Stephenson

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Michael B Sporn

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Nanjoo Suh

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Paul Talalay

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Renee Risingsong

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Tadashi Honda

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W David Holtzclaw

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Xiangqun Gao

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P2860

Heme oxygenase-1: the "emerging molecule" has arrived

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

Nrf2-Keap1 defines a physiologically important stress response mechanism

Novel synthetic oleanane and ursane triterpenoids with various enone functionalities in ring A as inhibitors of nitric oxide production in mouse macrophages

Parallel induction of heme oxygenase-1 and chemoprotective phase 2 enzymes by electrophiles and antioxidants: regulation by upstream antioxidant-responsive elements (ARE)

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers

Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis.

Molecular basis for the contribution of the antioxidant responsive element to cancer chemoprevention.

Therapeutic potential of dietary phase 2 enzyme inducers in ameliorating diseases that have an underlying inflammatory component.

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4584-4589

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4025990

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10.1073/PNAS.0500815102

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12

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102

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Albena T Dinkova-Kostova

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7966394

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