The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth
about
Defects in tendon, ligament, and enthesis in response to genetic alterations in key proteoglycans and glycoproteins: a reviewA systems biology approach to synovial joint lubrication in health, injury, and diseaseThe role of lubricin in the mechanical behavior of synovial fluidOsteoarthritis year 2011 in review: biologyIs the spinal motion segment a diarthrodial polyaxial joint: what a nice nucleus like you doing in a joint like this?Lubricin/Proteoglycan 4 binds to and regulates the activity of Toll-Like Receptors In Vitro.Articular Cartilage: Structural and Developmental Intricacies and QuestionsAging-related loss of the chromatin protein HMGB2 in articular cartilage is linked to reduced cellularity and osteoarthritisProteoglycan 4, a novel immunomodulatory factor, regulates parathyroid hormone actions on hematopoietic cellsMultimodal evaluation of tissue-engineered cartilage.Jellyfish mucin may have potential disease-modifying effects on osteoarthritis.Interaction of lubricin with type II collagen surfaces: adsorption, friction, and normal forces.In situ friction measurement on murine cartilage by atomic force microscopyIdentification of differentially expressed genes in fibroblasts derived from patients with Dupuytren's ContractureRegulation of the friction coefficient of articular cartilage by TGF-beta1 and IL-1beta.The autocrine role of proteoglycan-4 (PRG4) in modulating osteoarthritic synoviocyte proliferation and expression of matrix degrading enzymes.RBP-Jκ-dependent Notch signaling is required for murine articular cartilage and joint maintenance.Superficial zone cellularity is deficient in mice lacking lubricin: a stereoscopic analysisSynovial joint morphogenesis requires the chondrogenic action of Sox5 and Sox6 in growth plate and articular cartilageLubricin as a novel nanostructured protein coating to reduce fibroblast densityDistribution of lubricin in the ruptured human rotator cuff and biceps tendon: a pilot studyFriction-Induced Mitochondrial Dysregulation Contributes to Joint Deterioration in Prg4 Knockout Mice.Synergistic Interactions of a Synthetic Lubricin-Mimetic with Fibronectin for Enhanced Wear Protection.Lubricin/proteoglycan 4 increases in both experimental and naturally occurring equine osteoarthritis.Lubricin is Required for the Structural Integrity and Post-natal Maintenance of TMJ.Proteoglycan 4: a dynamic regulator of skeletogenesis and parathyroid hormone skeletal anabolism.Cartilage-specific ablation of site-1 protease in mice results in the endoplasmic reticulum entrapment of type IIb procollagen and down-regulation of cholesterol and lipid homeostasis.Lubricin protects the temporomandibular joint surfaces from degeneration.Loss of cartilage structure, stiffness, and frictional properties in mice lacking PRG4.The effect of tendon surface treatment on cell attachment for potential enhancement of tendon graft healing: an ex vivo modelExtracorporeal shockwave-induced expression of lubricin in tendons and septa.Mass spectrometry assays of plasma biomarkers to predict radiographic progression of knee osteoarthritis.Isolation and characterization of multipotential mesenchymal cells from the mouse synovium.Consequences of disease-causing mutations on lubricin protein synthesis, secretion, and post-translational processing.Effects of supplemental intra-articular lubricin and hyaluronic acid on the progression of posttraumatic arthritis in the anterior cruciate ligament-deficient rat knee.The transcription factors SOX9 and SOX5/SOX6 cooperate genome-wide through super-enhancers to drive chondrogenesisMapping lubricin in canine musculoskeletal tissues.Proteoglycan 4 expression protects against the development of osteoarthritisMaintaining mRNA integrity during decalcification of mineralized tissues.Surface zone articular chondrocytes modulate the bulk and surface mechanical properties of the tissue-engineered cartilage.
P2860
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P2860
The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth
description
2005 nî lūn-bûn
@nan
2005 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի մարտին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
name
The secreted glycoprotein lubr ...... ibits synovial cell overgrowth
@ast
The secreted glycoprotein lubr ...... ibits synovial cell overgrowth
@en
The secreted glycoprotein lubr ...... ibits synovial cell overgrowth
@nl
type
label
The secreted glycoprotein lubr ...... ibits synovial cell overgrowth
@ast
The secreted glycoprotein lubr ...... ibits synovial cell overgrowth
@en
The secreted glycoprotein lubr ...... ibits synovial cell overgrowth
@nl
prefLabel
The secreted glycoprotein lubr ...... ibits synovial cell overgrowth
@ast
The secreted glycoprotein lubr ...... ibits synovial cell overgrowth
@en
The secreted glycoprotein lubr ...... ibits synovial cell overgrowth
@nl
P2093
P2860
P3181
P1476
The secreted glycoprotein lubr ...... ibits synovial cell overgrowth
@en
P2093
David K Rhee
Hongwei Wang
John D Carpten
Jose Marcelino
MacArthur Baker
Matthew L Warman
Matthew Stewart
Patrick Smits
Véronique Lefebvre
Yaoqin Gong
P2860
P304
P3181
P356
10.1172/JCI200522263
10.1172/JCI22263
P407
P577
2005-03-01T00:00:00Z