Toxins A and B from Clostridium difficile differ with respect to enzymatic potencies, cellular substrate specificities, and surface binding to cultured cells
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Clostridium difficile toxins: mechanism of action and role in disease.Clostridium difficile Toxins A and B: Insights into Pathogenic Properties and Extraintestinal EffectsReactive Oxygen Species as Additional Determinants for Cytotoxicity of Clostridium difficile Toxins A and BThe Role of Rho GTPases in Toxicity of Clostridium difficile ToxinsStructural Determinants of Clostridium difficile Toxin A Glucosyltransferase ActivityThe structure of Clostridium difficile toxin A glucosyltransferase domain bound to Mn2+ and UDP provides insights into glucosyltransferase activity and product releaseHigh temporal resolution of glucosyltransferase dependent and independent effects of Clostridium difficile toxins across multiple cell types.Inflammasome activation contributes to interleukin-23 production in response to Clostridium difficile.In vivo physiological and transcriptional profiling reveals host responses to Clostridium difficile toxin A and toxin BSystems analysis of the transcriptional response of human ileocecal epithelial cells to Clostridium difficile toxins and effects on cell cycle control.Clostridium difficile toxins A and B are cation-dependent UDP-glucose hydrolases with differing catalytic activities.Signaling involved in neurite outgrowth of postnatally born subventricular zone neurons in vitro.Cloning, expression and characterization of a mammalian Nudix hydrolase-like enzyme that cleaves the pyrophosphate bond of UDP-glucoseClostridium difficile toxins disrupt epithelial barrier function by altering membrane microdomain localization of tight junction proteins.Clostridium sordellii lethal toxin is maintained in a multimeric protein complexp38 MAP kinase activation by Clostridium difficile toxin A mediates monocyte necrosis, IL-8 production, and enteritis.The p42/p44 MAP kinase pathway prevents apoptosis induced by anchorage and serum removal.Persistence and toxin production by Clostridium difficile within human intestinal organoids result in disruption of epithelial paracellular barrier function.Critical roles of Clostridium difficile toxin B enzymatic activities in pathogenesis.Identification of an epithelial cell receptor responsible for Clostridium difficile TcdB-induced cytotoxicity.Toward a structural understanding of Clostridium difficile toxins A and B.Glucosyltransferase activity of Clostridium difficile Toxin B is essential for disease pathogenesis.Modulation of toxin production by the flagellar regulon in Clostridium difficile.Antibiotic-associated diarrhoea.Analysis of TcdB Proteins within the Hypervirulent Clade 2 Reveals an Impact of RhoA Glucosylation on Clostridium difficile Proinflammatory Activities.A segment of 97 amino acids within the translocation domain of Clostridium difficile toxin B is essential for toxicityBiophysical Characterization and Activity of Lymphostatin, a Multifunctional Virulence Factor of Attaching and Effacing Escherichia coli.Protective efficacy induced by recombinant Clostridium difficile toxin fragmentsClostridium difficile toxin B-induced necrosis is mediated by the host epithelial cell NADPH oxidase complex.Clostridium difficile toxin A binds colonocyte Src causing dephosphorylation of focal adhesion kinase and paxillin.Variations in virulence and molecular biology among emerging strains of Clostridium difficile.Recent insights into Pasteurella multocida toxin and other G-protein-modulating bacterial toxins.Vaccines against Clostridium difficile.A novel cytotoxin from Clostridium difficile serogroup F is a functional hybrid between two other large clostridial cytotoxins.Glucosyltransferase-dependent and -independent effects of TcdB on the proteome of HEp-2 cells.Investigation of the Cross-talk Mechanism in Caco-2 Cells during Clostridium difficile Infection through Genetic-and-Epigenetic Interspecies Networks: Big Data Mining and Genome-Wide Identification.Pathogenic effects of glucosyltransferase from Clostridium difficile toxins.Tolevamer, an anionic polymer, neutralizes toxins produced by the BI/027 strains of Clostridium difficile.Glucosyltransferase Activity of Clostridium difficile Toxin B Triggers Autophagy-mediated Cell Growth Arrest.Difference in the cytotoxic effects of toxin B from Clostridium difficile strain VPI 10463 and toxin B from variant Clostridium difficile strain 1470.
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P2860
Toxins A and B from Clostridium difficile differ with respect to enzymatic potencies, cellular substrate specificities, and surface binding to cultured cells
description
1997 nî lūn-bûn
@nan
1997 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Toxins A and B from Clostridiu ...... face binding to cultured cells
@ast
Toxins A and B from Clostridiu ...... face binding to cultured cells
@en
Toxins A and B from Clostridiu ...... face binding to cultured cells
@nl
type
label
Toxins A and B from Clostridiu ...... face binding to cultured cells
@ast
Toxins A and B from Clostridiu ...... face binding to cultured cells
@en
Toxins A and B from Clostridiu ...... face binding to cultured cells
@nl
prefLabel
Toxins A and B from Clostridiu ...... face binding to cultured cells
@ast
Toxins A and B from Clostridiu ...... face binding to cultured cells
@en
Toxins A and B from Clostridiu ...... face binding to cultured cells
@nl
P2093
P2860
P3181
P356
P1476
Toxins A and B from Clostridiu ...... face binding to cultured cells
@en
P2093
C Eichel-Streiber
E Chaves-Olarte
M Thelestam
P2860
P304
P3181
P356
10.1172/JCI119698
P407
P577
1997-10-01T00:00:00Z