A direct binding site for Grb2 contributes to transformation and leukemogenesis by the Tel-Abl (ETV6-Abl) tyrosine kinase - Wikidata - awgldk - TriplyDB

A direct binding site for Grb2 contributes to transformation and leukemogenesis by the Tel-Abl (ETV6-Abl) tyrosine kinase

A direct binding site for Grb2 contributes to transformation and leukemogenesis by the Tel-Abl (ETV6-Abl) tyrosine kinase

http://www.wikidata.org/entity/Q24563301

about

Function, regulation and pathological roles of the Gab/DOS docking proteins Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein GAB2--a scaffolding protein in cancer Germline mutations in ETV6 are associated with thrombocytopenia, red cell macrocytosis and predisposition to lymphoblastic leukemia.Inhibition of Grb2 expression demonstrates an important role in BCR-ABL-mediated MAPK activation and transformation of primary human hematopoietic cells Kinase domain mutants of Bcr-Abl exhibit altered transformation potency, kinase activity, and substrate utilization, irrespective of sensitivity to imatinib.A novel Stat3 binding motif in Gab2 mediates transformation of primary hematopoietic cells by the Stk/Ron receptor tyrosine kinase in response to Friend virus infection Structure, regulation, signaling, and targeting of abl kinases in cancer.Characterization of leukemias with ETV6-ABL1 fusion Myeloproliferative neoplasm with ETV6-ABL1 fusion: a case report and literature review.Variant of ETV6/ABL1 gene is associated with leukemia phenotype.Gab adapter proteins as therapeutic targets for hematologic disease.The Src tyrosine kinase Hck is required for Tel-Abl- but not for Tel-Jak2-induced cell transformation.The role of RAS effectors in BCR/ABL induced chronic myelogenous leukemia.A Case of Chronic Myeloid Leukemia With Rare Variant ETV6/ABL1 Rearrangement.Identification and characterization of activating ABL1 1b kinase mutations: impact on sensitivity to ATP-competitive and allosteric ABL1 inhibitors.SHP2 is required for BCR-ABL1-induced hematologic neoplasia.ETV6-ABL1 fusion combined with monosomy 7 in childhood B-precursor acute lymphoblastic leukemia.TEL/AML1-positive patients lacking TEL exon 5 resemble canonical TEL/AML1 cases.FLT3 is fused to ETV6 in a myeloproliferative disorder with hypereosinophilia and a t(12;13)(p13;q12) translocation.

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P2860

A direct binding site for Grb2 contributes to transformation and leukemogenesis by the Tel-Abl (ETV6-Abl) tyrosine kinase

http://www.wikidata.org/entity/Q24563301

description

2004 nî lūn-bûn

@nan

2004 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի հունիսին հրատարակված գիտական հոդված

@hy

2004年の論文

@ja

2004年学术文章

@wuu

2004年学术文章

@zh-cn

2004年学术文章

@zh-hans

2004年学术文章

@zh-my

2004年学术文章

@zh-sg

2004年學術文章

@yue

name

A direct binding site for Grb2 ...... Abl (ETV6-Abl) tyrosine kinase

@ast

A direct binding site for Grb2 ...... Abl (ETV6-Abl) tyrosine kinase

@en

A direct binding site for Grb2 ...... Abl (ETV6-Abl) tyrosine kinase

@nl

type

label

A direct binding site for Grb2 ...... Abl (ETV6-Abl) tyrosine kinase

@ast

A direct binding site for Grb2 ...... Abl (ETV6-Abl) tyrosine kinase

@en

A direct binding site for Grb2 ...... Abl (ETV6-Abl) tyrosine kinase

@nl

prefLabel

A direct binding site for Grb2 ...... Abl (ETV6-Abl) tyrosine kinase

@ast

A direct binding site for Grb2 ...... Abl (ETV6-Abl) tyrosine kinase

@en

A direct binding site for Grb2 ...... Abl (ETV6-Abl) tyrosine kinase

@nl

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P356

MCB.24.11.4685-4695.2004

P1433

Molecular and Cellular Biology

P1476

A direct binding site for Grb2 ...... Abl (ETV6-Abl) tyrosine kinase

@en

P2093

Lyuba Varticovski

http://www.w3.org/2001/XMLSchema#string

Nari Harakawa

http://www.w3.org/2001/XMLSchema#string

Richard A Van Etten

http://www.w3.org/2001/XMLSchema#string

Ryan P Million

http://www.w3.org/2001/XMLSchema#string

Sergei Roumiantsev

http://www.w3.org/2001/XMLSchema#string

P2860

The Grb2 binding site is required for the induction of chronic myeloid leukemia-like disease in mice by the Bcr/Abl tyrosine kinase

Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway

Chronic myelocytic leukemia with eosinophilia, t(9;12)(q34;p13), and ETV6-ABL gene rearrangement: case report and review of the literature

Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation

Critical role for Gab2 in transformation by BCR/ABL

Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav

Autoinhibition of Bcr-Abl through its SH3 domain.

Mutational analysis of the regulatory function of the c-Abl Src homology 3 domain.

Chronic myelogenous leukemia blast cell proliferation is inhibited by peptides that disrupt Grb2-SoS complexes.

Identification of an atypical Grb2 carboxyl-terminal SH3 domain binding site in Gab docking proteins reveals Grb2-dependent and -independent recruitment of Gab1 to receptor tyrosine kinases.

P304

4685-95

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scholarly article

P356

10.1128/MCB.24.11.4685-4695.2004

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11

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24

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2004-06-01T00:00:00Z

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15143164

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P932

416425

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