Susceptibility to hepatocellular carcinoma is associated with genetic variation in the enzymatic detoxification of aflatoxin B1 - Wikidata - awgldk - TriplyDB

Susceptibility to hepatocellular carcinoma is associated with genetic variation in the enzymatic detoxification of aflatoxin B1

Susceptibility to hepatocellular carcinoma is associated with genetic variation in the enzymatic detoxification of aflatoxin B1

http://www.wikidata.org/entity/Q24563504

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Aflatoxin: a 50-year odyssey of mechanistic and translational toxicology The role of genetic polymorphisms in environmental health.Autoantibody response to microsomal epoxide hydrolase in hepatitis C and A Quantifying heterogeneity in exposure-risk relationships using exhaled breath biomarkers for 1,3-butadiene exposures Targeted disruption of the microsomal epoxide hydrolase gene. Microsomal epoxide hydrolase is required for the carcinogenic activity of 7,12-dimethylbenz[a]anthracene Genome-wide and differential proteomic analysis of hepatitis B virus and aflatoxin B1 related hepatocellular carcinoma in Guangxi, China Kinetics of hydrolysis and reaction of aflatoxin B1 exo-8,9-epoxide and relevance to toxicity and detoxication.Genetic polymorphisms of human N-acetyltransferase, cytochrome P450, glutathione-S-transferase, and epoxide hydrolase enzymes: relevance to xenobiotic metabolism and toxicity.Polymorphisms of xenobiotic-metabolizing enzymes and susceptibility to cancer Genetic epidemiology of environmental toxicity and cancer susceptibility: human allelic polymorphisms in drug-metabolizing enzyme genes, their functional importance, and nomenclature issues.Hepatitis B virus biology.Functional analysis of human microsomal epoxide hydrolase genetic variants.Alternative promoters determine tissue-specific expression profiles of the human microsomal epoxide hydrolase gene (EPHX1).A polymorphism in the gene for microsomal epoxide hydrolase is associated with pre-eclampsia.Hepatocellular carcinoma and the underlying mechanisms.Human hepatocellular carcinoma is characterized by a highly consistent pattern of genomic imbalances, including frequent loss of 16q23.1-24.1.Lack of association of EPHX1 gene polymorphisms with risk of hepatocellular carcinoma: a meta-analysis.Polymorphism of glutathione S-transferase mu 1 and theta 1 genes and hepatocellular carcinoma in southern Guangxi, China.Androgen receptor promotes hepatitis B virus-induced hepatocarcinogenesis through modulation of hepatitis B virus RNA transcription.Association of GST genetic polymorphisms with the susceptibility to hepatocellular carcinoma (HCC) in Chinese population evaluated by an updated systematic meta-analysis Meta-analysis of microsomal epoxide hydrolase gene polymorphism and risk of hepatocellular carcinoma Genetic mechanisms of hepatocarcinogenesis.Modulation of aflatoxin B1-mediated genotoxicity in primary cultures of human hepatocytes by diindolylmethane, curcumin, and xanthohumols.Insights into the pathogenesis and treatment of cancer from inborn errors of metabolism.The Environmental Genome Project: functional analysis of polymorphisms.Dietary aflatoxin exposure and chemoprevention of cancer: a clinical review.GST polymorphisms are associated with hepatocellular carcinoma risk in Chinese population.Genetic polymorphisms in biotransformation enzymes in Crohn's disease: association with microsomal epoxide hydrolase.Development of monoclonal antibodies to human microsomal epoxide hydrolase and analysis of "preneoplastic antigen"-like molecules.CYP1A1, GSTs and mEH polymorphisms and susceptibility to esophageal carcinoma: study of population from a high- incidence area in north China Chemopreventive effect of oltipraz on AFB(1)-induced hepatocarcinogenesis in tree shrew model.Susceptibility to hepatocellular carcinoma associated with null genotypes of GSTM1 and GSTT1.Determinants of formation of aflatoxin-albumin adducts: a seven-township study in Taiwan Microsomal Epoxide Hydrolase Polymorphisms and Haplotypes as Determinants of Hepatitis B Virusand Hepatitis C Virus-related Liver Disease in Indian Population Association of p53 genomic instability with the glutathione S-transferase null genotype in gastric cancer in the Portuguese population.Genetic polymorphisms in human drug-metabolizing enzymes: potential uses of reverse genetics to identify genes of toxicological relevance.Interactions of chemical carcinogens and genetic variation in hepatocellular carcinoma.Polymerase chain reaction and in situ hybridization: applications in toxicological pathology.Genetic alterations in hepatocellular carcinomas: association between loss of chromosome 4q and p53 gene mutations.Involvement of cytochrome P450, glutathione S-transferase, and epoxide hydrolase in the metabolism of aflatoxin B1 and relevance to risk of human liver cancer

P2860

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P2860

Susceptibility to hepatocellular carcinoma is associated with genetic variation in the enzymatic detoxification of aflatoxin B1

http://www.wikidata.org/entity/Q24563504

description

1995 nî lūn-bûn

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1995 թուականի Մարտին հրատարակուած գիտական յօդուած

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1995 թվականի մարտին հրատարակված գիտական հոդված

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1995年の論文

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1995年論文

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1995年論文

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1995年論文

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Susceptibility to hepatocellul ...... detoxification of aflatoxin B1

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Susceptibility to hepatocellul ...... detoxification of aflatoxin B1

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Susceptibility to hepatocellul ...... detoxification of aflatoxin B1

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Susceptibility to hepatocellul ...... detoxification of aflatoxin B1

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Susceptibility to hepatocellul ...... detoxification of aflatoxin B1

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Susceptibility to hepatocellul ...... detoxification of aflatoxin B1

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Susceptibility to hepatocellul ...... detoxification of aflatoxin B1

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Susceptibility to hepatocellul ...... detoxification of aflatoxin B1

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Susceptibility to hepatocellul ...... detoxification of aflatoxin B1

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Susceptibility to hepatocellul ...... detoxification of aflatoxin B1

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A Baffoe-Bonnie

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C P Wild

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E A Rosvold

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E D Lustbader

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K A McGlynn

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M L Clapper

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T Zhou

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X L Xia

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Y Hu

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P2860

Human microsomal epoxide hydrolase: genetic polymorphism and functional expression in vitro of amino acid variants

Aflatoxin B1 induces the transversion of G-->T in codon 249 of the p53 tumor suppressor gene in human hepatocytes

Antioncogenes and human cancer.

p53 mutations cluster at codon 249 in hepatitis B virus-positive hepatocellular carcinomas from China.

Urinary aflatoxin biomarkers and risk of hepatocellular carcinoma.

Human microsomal xenobiotic epoxide hydrolase. Complementary DNA sequence, complementary DNA-directed expression in COS-1 cells, and chromosomal localization.

Utility of PCR for DNA analysis from dried blood spots on filter paper blotters.

Low frequency of p53 mutations observed in a diverse collection of primary hepatocellular carcinomas

Base substitution mutations induced by metabolically activated aflatoxin B1.

Genetic heterogeneity of the human glutathione transferases: a complex of gene families.

P304

2384-7

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10.1073/PNAS.92.6.2384

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6

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