In vitro pharmacological characterization of AM1241: a protean agonist at the cannabinoid CB2 receptor? - Wikidata - awgldk - TriplyDB

In vitro pharmacological characterization of AM1241: a protean agonist at the cannabinoid CB2 receptor?

In vitro pharmacological characterization of AM1241: a protean agonist at the cannabinoid CB2 receptor?

http://www.wikidata.org/entity/Q24564956

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A cannabinoid 2 receptor agonist attenuates bone cancer-induced pain and bone loss In vitro and in vivo characterization of A-796260: a selective cannabinoid CB2 receptor agonist exhibiting analgesic activity in rodent pain models Differential effects of cannabinoid receptor agonists on regional brain activity using pharmacological MRI.The CB2 cannabinoid agonist AM-1241 prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis when initiated at symptom onset The cannabinoid CB2 receptor as a target for inflammation-dependent neurodegeneration Species-specific in vitro pharmacological effects of the cannabinoid receptor 2 (CB2) selective ligand AM1241 and its resolved enantiomers Minireview: From the bench, toward the clinic: therapeutic opportunities for cannabinoid receptor modulation Expression of functional cannabinoid CB2 receptor in VTA dopamine neurons in rats Targeting cannabinoid agonists for inflammatory and neuropathic pain Contributions of academic laboratories to the discovery and development of chemical biology tools The natural product magnolol as a lead structure for the development of potent cannabinoid receptor agonists The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors Antinociceptive effects of racemic AM1241 and its chirally synthesized enantiomers: lack of dependence upon opioid receptor activation.CB2: a cannabinoid receptor with an identity crisis The plant cannabinoid Delta9-tetrahydrocannabivarin can decrease signs of inflammation and inflammatory pain in mice.Pharmacological characterization of a novel cannabinoid ligand, MDA19, for treatment of neuropathic pain CB2 Cannabinoid receptors as a therapeutic target-what does the future hold?Brain cannabinoid CB₂ receptors modulate cocaine's actions in mice The promise and dilemma of cannabinoid therapy: lessons from animal studies of bone disease.The CB2 cannabinoid receptor-selective agonist O-3223 reduces pain and inflammation without apparent cannabinoid behavioral effects.Peripheral and central sites of action for the non-selective cannabinoid agonist WIN 55,212-2 in a rat model of post-operative pain Cannabinoid receptors: where they are and what they do.Selective activation of cannabinoid CB2 receptors suppresses neuropathic nociception induced by treatment with the chemotherapeutic agent paclitaxel in rats Cannabinoids attenuate cancer pain and proliferation in a mouse model Species differences in cannabinoid receptor 2 and receptor responses to cocaine self-administration in mice and rats 4'-O-methylhonokiol increases levels of 2-arachidonoyl glycerol in mouse brain via selective inhibition of its COX-2-mediated oxygenation.The endocannabinoid system: an overview.CB₂: therapeutic target-in-waiting AM630 behaves as a protean ligand at the human cannabinoid CB2 receptor.Therapeutic modulation of cannabinoid lipid signaling: metabolic profiling of a novel antinociceptive cannabinoid-2 receptor agonist Cannabinoid CB2 receptors: a therapeutic target for the treatment of inflammatory and neuropathic pain.Emerging strategies for exploiting cannabinoid receptor agonists as medicines.Targeting CB2 receptors and the endocannabinoid system for the treatment of pain.Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity.Current and emerging "at-site" pain medications: a review Synergistic combinations of the dual enkephalinase inhibitor PL265 given orally with various analgesic compounds acting on different targets, in a murine model of cancer-induced bone pain.Immunofluorescent spectral analysis reveals the intrathecal cannabinoid agonist, AM1241, produces spinal anti-inflammatory cytokine responses in neuropathic rats exhibiting relief from allodynia.Therapeutic Strategies Under Development Targeting Inflammatory Mechanisms in Amyotrophic Lateral Sclerosis.The Central Role of Glia in Pathological Pain and the Potential of Targeting the Cannabinoid 2 Receptor for Pain Relief.Constitutive activity of cannabinoid-2 (CB2) receptors plays an essential role in the protean agonism of (+)AM1241 and L768242.

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In vitro pharmacological characterization of AM1241: a protean agonist at the cannabinoid CB2 receptor?

http://www.wikidata.org/entity/Q24564956

description

2006 nî lūn-bûn

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2006 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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Identification and cloning of three novel human G protein-coupled receptor genes GPR52, PsiGPR53 and GPR55: GPR55 is extensively expressed in human brain

Molecular cloning, expression and function of the murine CB2 peripheral cannabinoid receptor

CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids

Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the CNS

Cannabinoid receptors and pain

Cloning and pharmacological characterization of the rat CB(2) cannabinoid receptor

Structure of a cannabinoid receptor and functional expression of the cloned cDNA

Molecular characterization of a peripheral receptor for cannabinoids

HU-308: a specific agonist for CB(2), a peripheral cannabinoid receptor

Cloning and molecular characterization of the rat CB2 cannabinoid receptor

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