Synthesis and biological properties of pinane-thromboxane A2, a selective inhibitor of coronary artery constriction, platelet aggregation, and thromboxane formation
about
GR32191, a highly potent and specific thromboxane A2 receptor blocking drug on platelets and vascular and airways smooth muscle in vitroDifluorothromboxane A2 and stereoisomers: stable derivatives of thromboxane A2 with differential effects on platelets and blood vesselsBinding of a radioiodinated 13-azapinane thromboxane antagonist to platelets: correlation with antiaggregatory activity in different speciesEvidence for human thromboxane receptor heterogeneity using a novel series of 9,11-cyclic carbonate derivatives of prostaglandin F2 alphaProstanoid receptor antagonists: development strategies and therapeutic applicationsThromboxane receptor signaling is required for fibronectin-induced matrix metalloproteinase 9 production by human and murine macrophages and is attenuated by the Arhgef1 molecule.The prostanoids in hemostasis and thrombosis: a review.Pinane thromboxane A2 analogues are non-selective prostanoid antagonists in rat and human stomach muscle.Responsiveness of platelets and coronary arteries from different species to synthetic thromboxane and prostaglandin endoperoxide analoguesDissociation of vasoconstrictor and platelet aggregatory activities of thromboxane by carbocyclic thromboxane A2, a stable analog of thromboxane A2.Solubilization of a thromboxane A2/prostaglandin H2 antagonist binding site from human platelets.Thromboxane A2 receptor: biology and function of a peculiar receptor that remains resistant for therapeutic targeting.The influence of Arhgef1 on pulmonary leukocyte function.Platelet and vessel associated prostacyclin and thromboxane A2/prostaglandin endoperoxide receptors.Repurposing an old drug for a new use: glybenclamide exerts antiplatelet activity by interacting with the thromboxane A(2) receptor.The Gq and G12 families of heterotrimeric G proteins report functional selectivity.Selective inhibition of thromboxane biosynthesis in human blood mononuclear cells and the effects of mitogen-stimulated lymphocyte proliferation.Competitive antagonism at thromboxane receptors in human platelets.Treatment of acute myocardial ischaemia with a selective antagonist of thromboxane receptors (BM 13.177).2-azapinanes: aza analogues of the enantiomeric pinyl carbocation intermediates in pinene biosynthesis.Ligand binding to thromboxane receptors on human platelets: correlation with biological activity.Effects of a selective thromboxane receptor antagonist (GR32191B) and of glyceryl trinitrate on bleeding time in man.
P2860
Q28341988-3742595A-2847-4A80-BA89-E5601F1C2078Q28359041-8313F2EC-9B83-4B8A-BC0F-52B08C8E0CD9Q28362060-83FC50F5-F146-42C9-85A1-7FD985BC3399Q28379254-CCAA58A0-ADD6-48C9-AE8A-25737CE6095FQ33485483-AC77ACC6-56DC-43ED-997E-EE6F4870B1E6Q35639711-4372D3D4-2F25-4E3E-9CBA-19306D42E1FCQ35863726-FDECE65E-93F7-4189-A750-5049BA13F435Q36097490-DFA59377-EC68-457B-B9BC-DFB978F21CECQ36097526-BB70E08B-E1A5-4496-8EA7-A60CF6C9802DQ36361638-0DF02E63-F194-4495-B2F8-92BBE8C6B152Q37554210-6E1C003B-F9BE-4C85-9C79-4BF30DDC6862Q37953820-6F863CDC-6B82-42C6-93D1-DA922D3ADB09Q38039975-E2F03241-FCA7-4495-ABFC-F3670F62D933Q38187995-7798251C-EDFF-411E-8749-1E60F6E6155AQ39019862-EC4D408B-879B-4F0C-85B4-F908C4E6E1DCQ39924947-B6191AE5-8ACC-4854-AE36-1D8D8162BA41Q39930185-E6057BFF-BC1E-4F15-94CB-48FDB537EF0FQ41740098-579FDDAA-1FAC-458F-B39C-43BC7309D6DEQ41885939-D09ED89B-E17C-4E28-84BA-194198371E4FQ42123452-30AF63D2-5BA4-4C1E-AFCF-0539FD49DA40Q42636041-732F6213-86C3-443A-B200-6B48B96E64FAQ43222811-87E42ACA-282E-4ECC-9AA4-C0202BFF48C9
P2860
Synthesis and biological properties of pinane-thromboxane A2, a selective inhibitor of coronary artery constriction, platelet aggregation, and thromboxane formation
description
1979 nî lūn-bûn
@nan
1979 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1979 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1979年の論文
@ja
1979年論文
@yue
1979年論文
@zh-hant
1979年論文
@zh-hk
1979年論文
@zh-mo
1979年論文
@zh-tw
1979年论文
@wuu
name
Synthesis and biological prope ...... ion, and thromboxane formation
@ast
Synthesis and biological prope ...... ion, and thromboxane formation
@en
Synthesis and biological prope ...... ion, and thromboxane formation
@nl
type
label
Synthesis and biological prope ...... ion, and thromboxane formation
@ast
Synthesis and biological prope ...... ion, and thromboxane formation
@en
Synthesis and biological prope ...... ion, and thromboxane formation
@nl
prefLabel
Synthesis and biological prope ...... ion, and thromboxane formation
@ast
Synthesis and biological prope ...... ion, and thromboxane formation
@en
Synthesis and biological prope ...... ion, and thromboxane formation
@nl
P2093
P2860
P356
P1476
Synthesis and biological prope ...... ion, and thromboxane formation
@en
P2093
K C Nicolaou
R L Magolda
P2860
P304
P356
10.1073/PNAS.76.6.2566
P407
P577
1979-06-01T00:00:00Z