The Rac1 splice form Rac1b promotes K-ras-induced lung tumorigenesis - Wikidata - awgldk - TriplyDB

The Rac1 splice form Rac1b promotes K-ras-induced lung tumorigenesis

The Rac1 splice form Rac1b promotes K-ras-induced lung tumorigenesis

http://www.wikidata.org/entity/Q24596918

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Update in lung cancer and mesothelioma 2012 Dynamic interplay between adhesion surfaces in carcinomas: Cell-cell and cell-matrix crosstalk Targeted therapies in development for non-small cell lung cancer Novel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPases ROS-induced epithelial-mesenchymal transition in mammary epithelial cells is mediated by NF-kB-dependent activation of Snail.Polyisoprenylated cysteinyl amide inhibitors disrupt actin cytoskeleton organization, induce cell rounding and block migration of non-small cell lung cancer.Tumor cell-derived MMP3 orchestrates Rac1b and tissue alterations that promote pancreatic adenocarcinoma.Sema3C promotes the survival and tumorigenicity of glioma stem cells through Rac1 activation.Oncogenic suppression of apoptosis uncovers a Rac1/JNK proliferation pathway activated by loss of Par3.Loss of RhoA Exacerbates, Rather Than Dampens, Oncogenic K-Ras Induced Lung Adenoma Formation in Mice.RAS signaling and anti-RAS therapy: lessons learned from genetically engineered mouse models, human cancer cells, and patient-related studies.Tumor cell expression of MMP3 as a prognostic factor for poor survival in pancreatic, pulmonary, and mammary carcinoma Genome and transcriptome sequencing of lung cancers reveal diverse mutational and splicing events.Ibuprofen inhibits colitis-induced overexpression of tumor-related Rac1b Extending the Impact of RAC1b Overexpression to Follicular Thyroid Carcinomas ROS production and NF-κB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation.Deregulation of Rho GTPases in cancer Distinct transcriptional changes in non-small cell lung cancer patients associated with multi-antigenic RNActive® CV9201 immunotherapy.TIPE2 suppresses angiogenesis and non-small cell lung cancer (NSCLC) invasiveness via inhibiting Rac1 activation and VEGF expression.Phosphorylation of SRSF1 by SRPK1 regulates alternative splicing of tumor-related Rac1b in colorectal cells.Rho GTPases modulate malignant transformation of tumor cells.Rac1b negatively regulates TGF-β1-induced cell motility in pancreatic ductal epithelial cells by suppressing Smad signalling Notch1 is required for Kras-induced lung adenocarcinoma and controls tumor cell survival via p53 Deregulation of splicing factors and breast cancer development.Rho GTPases: Anti- or pro-neoplastic targets?The role of TGF-β and its crosstalk with RAC1/RAC1b signaling in breast and pancreas carcinoma.Rac1b enhances cell survival through activation of the JNK2/c-JUN/Cyclin-D1 and AKT2/MCL1 pathways.Rac1 in human diseases: The therapeutic potential of targeting Rac1 signaling regulatory mechanisms.The role of small GTPases of the Rho/Rac family in TGF-β-induced EMT and cell motility in cancer.Rho GTPases, their post-translational modifications, disease-associated mutations and pharmacological inhibitors.Emerging roles of RAC1 in treating lung cancer patients.Insufficient ability of Rac1b to perturb cystogenesis.A network-based analysis of colon cancer splicing changes reveals a tumorigenesis-favoring regulatory pathway emanating from ELK1 MiR-622 inhibited colorectal cancer occurrence and metastasis by suppressing K-Ras.Identification of recurrent regulated alternative splicing events across human solid tumors.Rho GTPases: Regulation and roles in cancer cell biology.SPSB1-mediated HnRNP A1 ubiquitylation regulates alternative splicing and cell migration in EGF signaling.Alternative-splicing defects in cancer: Splicing regulators and their downstream targets, guiding the way to novel cancer therapeutics.Ovarian Tumor Microenvironment Signaling: Convergence on the Rac1 GTPase

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The Rac1 splice form Rac1b promotes K-ras-induced lung tumorigenesis

http://www.wikidata.org/entity/Q24596918

description

2013 nî lūn-bûn

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2013 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի փետրվարին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

@zh-hant

2013年論文

@zh-hk

2013年論文

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2013年論文

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@wuu

name

The Rac1 splice form Rac1b promotes K-ras-induced lung tumorigenesis

@ast

The Rac1 splice form Rac1b promotes K-ras-induced lung tumorigenesis

@en

The Rac1 splice form Rac1b promotes K-ras-induced lung tumorigenesis

@nl

type

label

The Rac1 splice form Rac1b promotes K-ras-induced lung tumorigenesis

@ast

The Rac1 splice form Rac1b promotes K-ras-induced lung tumorigenesis

@en

The Rac1 splice form Rac1b promotes K-ras-induced lung tumorigenesis

@nl

prefLabel

The Rac1 splice form Rac1b promotes K-ras-induced lung tumorigenesis

@ast

The Rac1 splice form Rac1b promotes K-ras-induced lung tumorigenesis

@en

The Rac1 splice form Rac1b promotes K-ras-induced lung tumorigenesis

@nl

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The Rac1 splice form Rac1b promotes K-ras-induced lung tumorigenesis

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A V Kossenkov

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A Vachani

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C Zhou

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J L Avila

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J L Kissil

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M Cho

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P Jiang

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Q Liu

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S Licciulli

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Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus

Alternative splicing of Rac1 generates Rac1b, a self-activating GTPase

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability

Cloning of a novel human Rac1b splice variant with increased expression in colorectal tumors.

The 19-amino acid insertion in the tumor-associated splice isoform Rac1b confers specific binding to p120 catenin.

Rho-family GTPases: it's not only Rac and Rho (and I like it).

Pak protein kinases and their role in cancer.

Rac1 in human breast cancer: overexpression, mutation analysis, and characterization of a new isoform, Rac1b.

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10.1038/ONC.2012.99

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