Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases - Wikidata - awgldk - TriplyDB

Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases

Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases

http://www.wikidata.org/entity/Q24597996

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Structural Mechanisms and Drug Discovery Prospects of Rho GTPases Molecular classification of gastric cancer: Towards a pathway-driven targeted therapy Approaches of targeting Rho GTPases in cancer drug discovery Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease Rational design of small molecule inhibitors targeting the Ras GEF, SOS1.Wnt5a and Wnt11 regulate mammalian anterior-posterior axis elongation Myxoma virus oncolytic efficiency can be enhanced through chemical or genetic disruption of the actin cytoskeleton Automated NMR fragment based screening identified a novel interface blocker to the LARG/RhoA complex A Pan-GTPase Inhibitor as a Molecular Probe A novel microtubule de-stabilizing complementarity-determining region C36L1 peptide displays antitumor activity against melanoma in vitro and in vivo Nuclear localization of Kaiso promotes the poorly differentiated phenotype and EMT in infiltrating ductal carcinomas Cellular mechanisms of tissue fibrosis. 8. Current and future drug targets in fibrosis: focus on Rho GTPase-regulated gene transcription.Bioinformatic approaches to augment study of epithelial-to-mesenchymal transition in lung cancer Targeting Rho-GTPases in immune cell migration and inflammation.Use of synthetic isoprenoids to target protein prenylation and Rho GTPases in breast cancer invasion Targeting GTPases in Parkinson's disease: comparison to the historic path of kinase drug discovery and perspectives Protein-protein interaction modulator drug discovery: past efforts and future opportunities using a rich source of low- and high-throughput screening assays.Combined rational design and a high throughput screening platform for identifying chemical inhibitors of a Ras-activating enzyme Loss of RhoA Exacerbates, Rather Than Dampens, Oncogenic K-Ras Induced Lung Adenoma Formation in Mice.RhoA and Rac1 GTPases Differentially Regulate Agonist-Receptor Mediated Reactive Oxygen Species Generation in Platelets Composite microsphere-functionalized scaffold for the controlled release of small molecules in tissue engineering.Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors ARHGEF15 overexpression worsens the prognosis in patients with pancreatic ductal adenocarcinoma through enhancing the motility and proliferative activity of the cancer cells.Cancer cell-derived 12(S)-HETE signals via 12-HETE receptor, RHO, ROCK and MLC2 to induce lymph endothelial barrier breaching.Cell type-specific signaling function of RhoA GTPase: lessons from mouse gene targeting.Diagnosis and Therapy of Atrial Fibrillation: The Past, The Present and The Future.Annexin A1 restores Aβ1-42 -induced blood-brain barrier disruption through the inhibition of RhoA-ROCK signaling pathway.Systematic approach identifies RHOA as a potential biomarker therapeutic target for Asian gastric cancer.Rho GTPases in erythroid maturation.Direct Modulation of Small GTPase Activity and Function.Molecular perturbation strategies to examine spatiotemporal features of Rho GEF and Rho GTPase activity in living cells.The lens actin filament cytoskeleton: Diverse structures for complex functions.Rho GTPases: Anti- or pro-neoplastic targets?Bud detachment in hydra requires activation of fibroblast growth factor receptor and a Rho-ROCK-myosin II signaling pathway to ensure formation of a basal constriction.Genomic landscape of gastric cancer: molecular classification and potential targets.Rho GTPases, their post-translational modifications, disease-associated mutations and pharmacological inhibitors.Rho GTPases and cancer.Rho GTPases as therapeutic targets in cancer (Review).Molecular pathways: targeting the kinase effectors of RHO-family GTPases.Stress responses. Mutations in a translation initiation factor identify the target of a memory-enhancing compound.

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P2860

Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases

http://www.wikidata.org/entity/Q24597996

description

2012 nî lūn-bûn

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2012 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2012年の論文

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2012年論文

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2012年论文

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Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases

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Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases

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Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases

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Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases

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Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases

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Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases

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Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases

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Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases

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Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases

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Yi Zheng

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P2860

Structural snapshots of the mechanism and inhibition of a guanine nucleotide exchange factor

Why molecules move along a temperature gradient

Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1

Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?

Rho GTPases and the actin cytoskeleton

Rho GTPases in cell biology

The guanine nucleotide-binding switch in three dimensions

Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho

Genomic analysis of metastasis reveals an essential role for RhoC

Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factor

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