Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA
about
Characterization of a novel phosphatidylinositol 3-phosphate-binding protein containing two FYVE fingers in tandem that is targeted to the GolgiAllosteric activation of the protein kinase PDK1 with low molecular weight compoundsA phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation.Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions.The atypical PKCs in inflammation: NF-κB and beyondPerspectives in PDK1 evolution: insights from photosynthetic and non-photosynthetic organismsHigh resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site.Structural basis for UCN-01 (7-hydroxystaurosporine) specificity and PDK1 (3-phosphoinositide-dependent protein kinase-1) inhibitionMutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin ResistanceStructural Diversity of the Active N-Terminal Kinase Domain of p90 Ribosomal S6 Kinase 2Turning a protein kinase on or off from a single allosteric site via disulfide trapping.Enzymatic activity with an incomplete catalytic spine: insights from a comparative structural analysis of human CK2α and its paralogous isoform CK2α'Small-Molecule Allosteric Modulators of the Protein Kinase PDK1 from Structure-Based DockingA 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta ) and PKC-related kinase 2 by PDK1Carboxyl-terminal region conserved among phosphoinositide-kinase-related kinases is indispensable for mTOR function in vivo and in vitroInhibition of insulin-induced activation of Akt by a kinase-deficient mutant of the epsilon isozyme of protein kinase CProtein kinase B is regulated in platelets by the collagen receptor glycoprotein VIPhosphorylation of the protein kinase C-theta activation loop and hydrophobic motif regulates its kinase activity, but only activation loop phosphorylation is critical to in vivo nuclear-factor-kappaB inductionThe PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB.Protein kinase N1, a cell inhibitor of Akt kinase, has a central role in quality control of germinal center formationMechanism for activation of the growth factor-activated AGC kinases by turn motif phosphorylationThe role of Asp-462 in regulating Akt activityRegulation of diacylglycerol kinase alpha by phosphoinositide 3-kinase lipid productsMultiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase BCharacterization of a PDK1 homologue from the moss Physcomitrella patensReengineering the signaling properties of a Src family kinase.Peptide and protein library screening defines optimal substrate motifs for AKT/PKB.Discovery of PDK1 kinase inhibitors with a novel mechanism of action by ultrahigh throughput screeningSubstrate and docking interactions in serine/threonine protein kinasesElastic network model of allosteric regulation in protein kinase PDK1Chemotactic activation of Dictyostelium AGC-family kinases AKT and PKBR1 requires separate but coordinated functions of PDK1 and TORC2Identification of small molecule inhibitors of the Aurora-A/TPX2 complexConserved modular domains team up to latch-open active protein kinase CαInhibition of Xenopus oocyte meiotic maturation by catalytically inactive protein kinase A.The adaptor protein Grb14 regulates the localization of 3-phosphoinositide-dependent kinase-1.Survey of the year 2000 commercial optical biosensor literature.PDK2: a complex tail in one Akt.A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1.Molecular basis for small molecule inhibition of G protein-coupled receptor kinasesRegulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm
P2860
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P2860
Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA
description
2000 nî lūn-bûn
@nan
2000 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի մարտին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Identification of a pocket in ...... the C-terminal residues of PKA
@ast
Identification of a pocket in ...... the C-terminal residues of PKA
@en
Identification of a pocket in ...... the C-terminal residues of PKA
@nl
type
label
Identification of a pocket in ...... the C-terminal residues of PKA
@ast
Identification of a pocket in ...... the C-terminal residues of PKA
@en
Identification of a pocket in ...... the C-terminal residues of PKA
@nl
prefLabel
Identification of a pocket in ...... the C-terminal residues of PKA
@ast
Identification of a pocket in ...... the C-terminal residues of PKA
@en
Identification of a pocket in ...... the C-terminal residues of PKA
@nl
P2093
P2860
P3181
P356
P1433
P1476
Identification of a pocket in ...... the C-terminal residues of PKA
@en
P2093
P2860
P304
P3181
P356
10.1093/EMBOJ/19.5.979
P407
P577
2000-03-01T00:00:00Z