Frequent mutation of BAP1 in metastasizing uveal melanomas
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EFS shows biallelic methylation in uveal melanoma with poor prognosis as well as tissue-specific methylationHigh incidence of somatic BAP1 alterations in sporadic malignant mesotheliomaASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repressionRecognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complexBAP1 is phosphorylated at serine 592 in S-phase following DNA damageGermline mutations in BAP1 predispose to melanocytic tumorsHistone deacetylase inhibitors induce growth arrest and differentiation in uveal melanomaExome sequencing identifies recurrent somatic RAC1 mutations in melanomaGermline BAP1 mutations predispose to malignant mesotheliomaMetastatic disease from uveal melanoma: treatment options and future prospectsRecent advances in molecular genetics of melanoma progression: implications for diagnosis and treatmentUveal melanoma as a target for immune-therapyUveal Melanoma Patient-Derived XenograftsDrosophila as a Potential Model for Ocular TumorsCulturing Uveal Melanoma CellsNovel Insights into the Role of Long Noncoding RNA in Ocular DiseasesUpcoming translational challenges for uveal melanomaUpdate in genetic susceptibility in melanomaFine-tuning the ubiquitin code at DNA double-strand breaks: deubiquitinating enzymes at workCross-species models of human melanomaAn Omics Perspective on Molecular Biomarkers for Diagnosis, Prognosis, and Therapeutics of CholangiocarcinomaRecent developments in prognostic and predictive testing in uveal melanomaFrom human genome to cancer genome: the first decadePathways and therapeutic targets in melanomaEmerging patterns of somatic mutations in cancerMetastatic uveal melanoma: biology and emerging treatmentsUveal melanoma cells utilize a novel route for transendothelial migrationEffects on survival of BAP1 and PBRM1 mutations in sporadic clear-cell renal-cell carcinoma: a retrospective analysis with independent validation.Adverse outcomes in clear cell renal cell carcinoma with mutations of 3p21 epigenetic regulators BAP1 and SETD2: a report by MSKCC and the KIRC TCGA research networkPrognostic parameters in uveal melanoma and their association with BAP1 expression.Loss of the deubiquitylase BAP1 alters class I histone deacetylase expression and sensitivity of mesothelioma cells to HDAC inhibitors.The genetics of uveal melanoma: current insightsUveal Melanoma: Current Trends in Diagnosis and ManagementThe roles of chromatin-remodelers and epigenetic modifiers in kidney cancerConnecting molecular pathways to hereditary cancer risk syndromesLoss of BAP1 Expression Occurs Frequently in Intrahepatic CholangiocarcinomaAn asbestos-exposed family with multiple cases of pleural malignant mesothelioma without inheritance of a predisposing BAP1 mutationGermline BAP1 mutation in a family with high incidence of multiple primary cancers and a potential gene-environment interactionMolecular pathways: targeting mechanisms of asbestos and erionite carcinogenesis in mesotheliomaComprehensive review of BAP1 tumor predisposition syndrome with report of two new cases
P2860
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P2860
Frequent mutation of BAP1 in metastasizing uveal melanomas
description
2010 nî lūn-bûn
@nan
2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Frequent mutation of BAP1 in metastasizing uveal melanomas
@ast
Frequent mutation of BAP1 in metastasizing uveal melanomas
@en
Frequent mutation of BAP1 in metastasizing uveal melanomas
@nl
type
label
Frequent mutation of BAP1 in metastasizing uveal melanomas
@ast
Frequent mutation of BAP1 in metastasizing uveal melanomas
@en
Frequent mutation of BAP1 in metastasizing uveal melanomas
@nl
prefLabel
Frequent mutation of BAP1 in metastasizing uveal melanomas
@ast
Frequent mutation of BAP1 in metastasizing uveal melanomas
@en
Frequent mutation of BAP1 in metastasizing uveal melanomas
@nl
P2093
P2860
P50
P3181
P356
P1433
P1476
Frequent mutation of BAP1 in metastasizing uveal melanomas
@en
P2093
Cynthia Helms
J William Harbour
Katie A Matatall
Lori A Worley
M Laurin Council
Shenghui Duan
P2860
P304
P3181
P356
10.1126/SCIENCE.1194472
P407
P577
2010-12-03T00:00:00Z