Molecular and functional characterization of amylin, a peptide associated with type 2 diabetes mellitus
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Molecular Structure, Membrane Interactions, and Toxicity of the Islet Amyloid Polypeptide in Type 2 Diabetes MellitusCausative factors for formation of toxic islet amyloid polypeptide oligomer in type 2 diabetes mellitusStructure and membrane orientation of IAPP in its natively amidated form at physiological pH in a membrane environmentAmyloidogenicity and cytotoxicity of recombinant mature human islet amyloid polypeptide (rhIAPP).Islet amyloid with macrophage migration correlates with augmented β-cell deficits in type 2 diabetic patientsStructural similarities and differences between amyloidogenic and non-amyloidogenic islet amyloid polypeptide (IAPP) sequences and implications for the dual physiological and pathological activities of these peptides.Mutational analysis of preamyloid intermediates: the role of his-tyr interactions in islet amyloid formationExpression, purification, and biological activity of the recombinant pramlintide precursor.Convergent chemoenzymatic synthesis of a library of glycosylated analogues of pramlintide: structure-activity relationships for amylin receptor agonism.Immunoreactivity and expression of amylin in gastroenteropancreatic endocrine tumorsEvidence for Conservation of the Calcitonin Superfamily and Activity-regulating Mechanisms in the Basal Chordate Branchiostoma floridae: INSIGHTS INTO THE MOLECULAR AND FUNCTIONAL EVOLUTION IN CHORDATESCalcitonin and Amylin Receptor Peptide Interaction Mechanisms: INSIGHTS INTO PEPTIDE-BINDING MODES AND ALLOSTERIC MODULATION OF THE CALCITONIN RECEPTOR BY RECEPTOR ACTIVITY-MODIFYING PROTEINS.Amylin structure-function relationships and receptor pharmacology: implications for amylin mimetic drug development.Effect of Post-Translational Amidation on Islet Amyloid Polypeptide Conformational Ensemble: Implications for Its Aggregation Early Steps.Atomic structures of fibrillar segments of hIAPP suggest tightly mated β-sheets are important for cytotoxicity.Amylin analogues in the treatment of diabetes mellitus: medicinal chemistry and structural basis of its function.Disulfide bonds in amyloidogenesis diseases related proteins.2DIR spectroscopy of human amylin fibrils reflects stable β-sheet structure.The ability of insulin to inhibit the formation of amyloid by pro-islet amyloid polypeptide processing intermediates is significantly reduced in the presence of sulfated glycosaminoglycans.Slow Internal Dynamics and Charge Expansion in the Disordered Protein CGRP: A Comparison with Amylin.Islet amyloid polypeptide: a review of its biology and potential roles in the pathogenesis of diabetes mellitus.Receptors for calcitonin, calcitonin gene related peptide, amylin, and adrenomedullin.Structural Properties of Human IAPP Dimer in Membrane Environment Studied by All-Atom Molecular Dynamics Simulations.Peptide Inhibitors of the amyloidogenesis of IAPP: verification of the hairpin-binding geometry hypothesis.On the role of the C-terminus of alpha-calcitonin-gene-related peptide (alpha CGRP). The structure of des-phenylalaninamide37-alpha CGRP and its interaction with the CGRP receptor.Physiological glucocorticoid levels regulate glutamine and insulin-mediated glucose metabolism in skeletal muscle of the rat. Studies with RU 486 (mifepristone)The role of the disulfide bond in the interaction of islet amyloid polypeptide with membranes.The effects of amylin on carbohydrate metabolism in skeletal muscle in vitro and in vivo.Amylin activates glycogen phosphorylase in the isolated soleus muscle of the rat.Human Islet Amyloid Polypeptide N-Terminus Fragment Self-Assembly: Effect of Conserved Disulfide Bond on Aggregation Propensity.8-37h-CGRP antagonizes actions of amylin on carbohydrate metabolism in vitro and in vivo.Structural and thermodynamical properties of early human amylin oligomers using replica exchange molecular dynamics: mutation effect of three key residues F15, H18 and F23.Coordination of Zn(2+) and Cu(2+) to the membrane disrupting fragment of amylin.Lambda II immunoglobulin light chain protein in primary localized rectal amyloidosis
P2860
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P2860
Molecular and functional characterization of amylin, a peptide associated with type 2 diabetes mellitus
description
1989 nî lūn-bûn
@nan
1989 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1989 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
name
Molecular and functional chara ...... with type 2 diabetes mellitus
@ast
Molecular and functional chara ...... with type 2 diabetes mellitus
@en
Molecular and functional chara ...... with type 2 diabetes mellitus
@nl
type
label
Molecular and functional chara ...... with type 2 diabetes mellitus
@ast
Molecular and functional chara ...... with type 2 diabetes mellitus
@en
Molecular and functional chara ...... with type 2 diabetes mellitus
@nl
prefLabel
Molecular and functional chara ...... with type 2 diabetes mellitus
@ast
Molecular and functional chara ...... with type 2 diabetes mellitus
@en
Molecular and functional chara ...... with type 2 diabetes mellitus
@nl
P2093
P2860
P356
P1476
Molecular and functional chara ...... with type 2 diabetes mellitus
@en
P2093
A N Roberts
B Leighton
D Cockburn
P N Schofield
P2860
P304
P356
10.1073/PNAS.86.24.9662
P407
P577
1989-12-01T00:00:00Z