Evolutionary and functional analyses of the interaction between the myeloid restriction factor SAMHD1 and the lentiviral Vpx protein - Wikidata - awgldk - TriplyDB

Evolutionary and functional analyses of the interaction between the myeloid restriction factor SAMHD1 and the lentiviral Vpx protein

Evolutionary and functional analyses of the interaction between the myeloid restriction factor SAMHD1 and the lentiviral Vpx protein

http://www.wikidata.org/entity/Q24605807

about

New insights into an X-traordinary viral protein Identification and characterization of naturally occurring splice variants of SAMHD1 The restriction factors of human immunodeficiency virus SAMHD1 restricts HIV-1 reverse transcription in quiescent CD4(+) T-cells Tetramerization of SAMHD1 is required for biological activity and inhibition of HIV infection Evolutionary conflicts between viruses and restriction factors shape immunity Molecular mechanisms of HIV immune evasion of the innate immune response in myeloid cells Functional organization of human SAMHD1 and mechanisms of HIV-1 restriction Cullin4A and cullin4B are interchangeable for HIV Vpr and Vpx action through the CRL4 ubiquitin ligase complex Intrinsic cellular defenses against human immunodeficiency viruses Host gene evolution traces the evolutionary history of ancient primate lentiviruses Dual host-virus arms races shape an essential housekeeping protein Evolutionary dynamics of the interferon-induced transmembrane gene family in vertebrates Interferon-induced HERC5 is evolving under positive selection and inhibits HIV-1 particle production by a novel mechanism targeting Rev/RRE-dependent RNA nuclear export.Co-evolution of primate SAMHD1 and lentivirus Vpx leads to the loss of the vpx gene in HIV-1 ancestor SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells.Macaques as model hosts for studies of HIV-1 infection Positive selection of primate genes that promote HIV-1 replication.Nuclear import of SAMHD1 is mediated by a classical karyopherin α/β1 dependent pathway and confers sensitivity to VpxMAC induced ubiquitination and proteasomal degradation.Effects of human SAMHD1 polymorphisms on HIV-1 susceptibility.Rapid evolution of BRCA1 and BRCA2 in humans and other primates.SAMHD1 has differential impact on the efficacies of HIV nucleoside reverse transcriptase inhibitors.HIV/simian immunodeficiency virus (SIV) accessory virulence factor Vpx loads the host cell restriction factor SAMHD1 onto the E3 ubiquitin ligase complex CRL4DCAF1.The Vpx lentiviral accessory protein targets SAMHD1 for degradation in the nucleus.Macrophages and their relevance in Human Immunodeficiency Virus Type I infection.Contribution of SAM and HD domains to retroviral restriction mediated by human SAMHD1.Novel factors interfering with human immunodeficiency virus-type 1 replication in vivo and in vitro.The retroviral restriction ability of SAMHD1, but not its deoxynucleotide triphosphohydrolase activity, is regulated by phosphorylation SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage.Cullin E3 ligases and their rewiring by viral factors Evolutionary toggling of Vpx/Vpr specificity results in divergent recognition of the restriction factor SAMHD1.Identification of critical regions in human SAMHD1 required for nuclear localization and Vpx-mediated degradation BCA2/Rabring7 targets HIV-1 Gag for lysosomal degradation in a tetherin-independent manner.The effect of species representation on the detection of positive selection in primate gene data sets.Molecular determinants for recognition of divergent SAMHD1 proteins by the lentiviral accessory protein Vpx.Identification of potential HIV restriction factors by combining evolutionary genomic signatures with functional analyses Potent Cell-Intrinsic Immune Responses in Dendritic Cells Facilitate HIV-1-Specific T Cell Immunity in HIV-1 Elite Controllers.SAMHD1 Inhibits LINE-1 Retrotransposition by Promoting Stress Granule Formation.Evolutionary and Functional Analysis of Old World Primate TRIM5 Reveals the Ancient Emergence of Primate Lentiviruses and Convergent Evolution Targeting a Conserved Capsid Interface PQBP1 Is a Proximal Sensor of the cGAS-Dependent Innate Response to HIV-1.

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Evolutionary and functional analyses of the interaction between the myeloid restriction factor SAMHD1 and the lentiviral Vpx protein

http://www.wikidata.org/entity/Q24605807

description

2012 nî lūn-bûn

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2012 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2012 թվականի փետրվարին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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J.CHOM.2012.01.007

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Cell Host & Microbe

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Evolutionary and functional an ...... and the lentiviral Vpx protein

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Bijan Sobhian

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Christine Chable-Bessia

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Daniel Sauter

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Jan Münch

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Joke Snoeck

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Monsef Benkirane

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Nadia Rahm

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Nadine Laguette

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P2860

A molecular phylogeny of living primates

Paleovirology--modern consequences of ancient viruses

OrthoMaM: a database of orthologous genomic markers for placental mammal phylogenetics

Ancient adaptive evolution of the primate antiviral DNA-editing enzyme APOBEC3G

Dating the age of the SIV lineages that gave rise to HIV-1 and HIV-2

Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases

Chimpanzee reservoirs of pandemic and nonpandemic HIV-1

Increased mortality and AIDS-like immunopathology in wild chimpanzees infected with SIVcpz

Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response

Specific recognition and accelerated uncoating of retroviral capsids by the TRIM5alpha restriction factor

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205-17

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scholarly article

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2923183

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10.1016/J.CHOM.2012.01.007

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2

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11

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Frank Kirchhoff

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William M Switzer

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2012-02-16T00:00:00Z

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221805895

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22305291

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