The replication focus targeting sequence (RFTS) domain is a DNA-competitive inhibitor of Dnmt1 - Wikidata - awgldk - TriplyDB

The replication focus targeting sequence (RFTS) domain is a DNA-competitive inhibitor of Dnmt1

The replication focus targeting sequence (RFTS) domain is a DNA-competitive inhibitor of Dnmt1

http://www.wikidata.org/entity/Q24606880

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Structural and functional coordination of DNA and histone methylation Mammalian epigenetic mechanisms The RFTS domain of Raf2 is required for Cul4 interaction and heterochromatin integrity in fission yeast Modulation of epigenetic targets for anticancer therapy: clinicopathological relevance, structural data and drug discovery perspectives Laccaic acid A is a direct, DNA-competitive inhibitor of DNA methyltransferase 1.RGS6 suppresses Ras-induced cellular transformation by facilitating Tip60-mediated Dnmt1 degradation and promoting apoptosis.Twists and turns of DNA methylation An ultrasensitive high throughput screen for DNA methyltransferase 1-targeted molecular probes Understanding the relationship between DNA methylation and histone lysine methylation.Genomic survey, gene expression analysis and structural modeling suggest diverse roles of DNA methyltransferases in legumes.Crystal Structure of Human DNA Methyltransferase 1 Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation RFTS-deleted DNMT1 enhances tumorigenicity with focal hypermethylation and global hypomethylation DNMT1 mutation hot spot causes varied phenotypes of HSAN1 with dementia and hearing loss.Reading between the Lines: "ADD"-ing Histone and DNA Methylation Marks toward a New Epigenetic "Sum".ZF-CxxC domain-containing proteins, CpG islands and the chromatin connection.Epigenetics of sleep and chronobiology.Genomic imprinting--the struggle of the genders at the molecular level.Interpreting the language of histone and DNA modifications.On the potential role of DNMT1 in acute myeloid leukemia and myelodysplastic syndromes: not another mutated epigenetic driver.DNA methylation requires a DNMT1 ubiquitin interacting motif (UIM) and histone ubiquitination Allosteric control of mammalian DNA methyltransferases - a new regulatory paradigm.Domain Structure of the Dnmt1, Dnmt3a, and Dnmt3b DNA Methyltransferases.Enzymology of Mammalian DNA Methyltransferases.Structure and Mechanism of Plant DNA Methyltransferases.Targeted mutagenesis results in an activation of DNA methyltransferase 1 and confirms an autoinhibitory role of its RFTS domain.The DNA methyltransferase Dnmt1 directly interacts with the SET and RING finger-associated (SRA) domain of the multifunctional protein Uhrf1 to facilitate accession of the catalytic center to hemi-methylated DNA.The UHRF1 protein stimulates the activity and specificity of the maintenance DNA methyltransferase DNMT1 by an allosteric mechanism.New insights on the mechanism of quinoline-based DNA Methyltransferase inhibitors.Usp7-dependent histone H3 deubiquitylation regulates maintenance of DNA methylation.DNMT1 mutations found in HSANIE patients affect interaction with UHRF1 and neuronal differentiation.DNMT1-associated DNA methylation changes in cancer.DNA methyltransferase 1 mutations and mitochondrial pathology: is mtDNA methylated?KRAS-driven miR-29b expression is required for tumor suppressor gene silencing.RFTS-dependent negative regulation of Dnmt1 by nucleosome structure and histone tails.Novel mutation in the replication focus targeting sequence domain of DNMT1 causes hereditary sensory and autonomic neuropathy IE.Target specificity of mammalian DNA methylation and demethylation machinery.Conserved threonine 1505 in the catalytic domain stabilizes mouse DNA methyltransferase 1.Structural and mechanistic insights into UHRF1-mediated DNMT1 activation in the maintenance DNA methylation.Computer-Aided Drug Design in Epigenetics.

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P2860

The replication focus targeting sequence (RFTS) domain is a DNA-competitive inhibitor of Dnmt1

http://www.wikidata.org/entity/Q24606880

description

2011 nî lūn-bûn

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2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի ապրիլին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

@zh-mo

2011年論文

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2011年论文

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name

The replication focus targetin ...... competitive inhibitor of Dnmt1

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The replication focus targetin ...... competitive inhibitor of Dnmt1

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The replication focus targetin ...... competitive inhibitor of Dnmt1

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type

label

The replication focus targetin ...... competitive inhibitor of Dnmt1

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The replication focus targetin ...... competitive inhibitor of Dnmt1

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The replication focus targetin ...... competitive inhibitor of Dnmt1

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The Replication Focus Targetin ...... competitive Inhibitor of Dnmt1

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The replication focus targetin ...... competitive inhibitor of Dnmt1

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The replication focus targetin ...... competitive inhibitor of Dnmt1

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The replication focus targetin ...... competitive inhibitor of Dnmt1

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JBC.M110.209882

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Journal of Biological Chemistry

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The replication focus targetin ...... competitive inhibitor of Dnmt1

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Farisa Syeda

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George V Avvakumov

http://www.w3.org/2001/XMLSchema#string

John R Walker

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Matthew Wean

http://www.w3.org/2001/XMLSchema#string

Sheng Xue

http://www.w3.org/2001/XMLSchema#string

P2860

DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci

Human DNA-(Cytosine-5) Methyltransferase-PCNA Complex as a Target for p21WAF1

The interaction of the SRA domain of ICBP90 with a novel domain of DNMT1 is involved in the regulation of VEGF gene expression

Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation

UHRF1 plays a role in maintaining DNA methylation in mammalian cells

CXXC domain of human DNMT1 is essential for enzymatic activity

Processing of X-ray diffraction data collected in oscillation mode

The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix

Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1

Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism

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15344-51

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scholarly article

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10.1074/JBC.M110.209882

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17

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286

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Sirano Dhe-Paganon

Charles Brenner

Rebecca L Fagan

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2011-04-29T00:00:00Z

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50351398

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21389349

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3083197

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