Mutations in MTO2 related to tRNA modification impair mitochondrial gene expression and protein synthesis in the presence of a paromomycin resistance mutation in mitochondrial 15 S rRNA
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Mutation in TRMU related to transfer RNA modification modulates the phenotypic expression of the deafness-associated mitochondrial 12S ribosomal RNA mutationsModification of the wobble uridine in bacterial and mitochondrial tRNAs reading NNA/NNG triplets of 2-codon boxesReduced TRMU expression increases the sensitivity of hair-cell-like HEI-OC-1 cells to neomycin damage in vitroResponse of mechanosensory hair cells of the zebrafish lateral line to aminoglycosides reveals distinct cell death pathways.Molecular and clinical characterization of the variable phenotype in Korean families with hearing loss associated with the mitochondrial A1555G mutation.Combination of the loss of cmnm5U34 with the lack of s2U34 modifications of tRNALys, tRNAGlu, and tRNAGln altered mitochondrial biogenesis and respiration.MTO1 mutations are associated with hypertrophic cardiomyopathy and lactic acidosis and cause respiratory chain deficiency in humans and yeast.Human mitochondrial leucyl-tRNA synthetase corrects mitochondrial dysfunctions due to the tRNALeu(UUR) A3243G mutation, associated with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like symptoms and diabetesA compendium of human mitochondrial gene expression machinery with links to disease.Characterization of human GTPBP3, a GTP-binding protein involved in mitochondrial tRNA modification.Nuclear modifier MTO2 modulates the aminoglycoside-sensitivity of mitochondrial 15S rRNA C1477G mutation in Saccharomyces cerevisiae.Mechanistic study on the nuclear modifier gene MSS1 mutation suppressing neomycin sensitivity of the mitochondrial 15S rRNA C1477G mutation in Saccharomyces cerevisiaeMTO1 worked as a modifier in the aminoglycosides sensitivity of yeast carrying a mitochondrial 15S rRNA C1477G mutationPathogenic mutations of nuclear genes associated with mitochondrial disorders.Altered mitochondrial function and genome frequency post exposure to γ-radiation and bystander factors.Biochemical Evidence for a Nuclear Modifier Allele (A10S) in TRMU (Methylaminomethyl-2-thiouridylate-methyltransferase) Related to Mitochondrial tRNA Modification in the Phenotypic Manifestation of Deafness-associated 12S rRNA Mutation.Mutations of the mitochondrial-tRNA modifier MTO1 cause hypertrophic cardiomyopathy and lactic acidosis.Mutation in MTO1 involved in tRNA modification impairs mitochondrial RNA metabolism in the yeast Saccharomyces cerevisiaeContribution of the tRNAIle 4317A>G mutation to the phenotypic manifestation of the deafness-associated mitochondrial 12S rRNA 1555A>G mutation.The role of mitochondrial tRNAPhe C628T variant in deafness expression.A cell death assay for assessing the mitochondrial targeting of proteins.The 2-thiouridylase function of the human MTU1 (TRMU) enzyme is dispensable for mitochondrial translation.Mitochondrial DNA mutations associated with aminoglycoside induced ototoxicity.
P2860
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P2860
Mutations in MTO2 related to tRNA modification impair mitochondrial gene expression and protein synthesis in the presence of a paromomycin resistance mutation in mitochondrial 15 S rRNA
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2005 nî lūn-bûn
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2005 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Mutations in MTO2 related to t ...... ion in mitochondrial 15 S rRNA
@ast
Mutations in MTO2 related to t ...... ion in mitochondrial 15 S rRNA
@en
Mutations in MTO2 related to t ...... ion in mitochondrial 15 S rRNA
@nl
type
label
Mutations in MTO2 related to t ...... ion in mitochondrial 15 S rRNA
@ast
Mutations in MTO2 related to t ...... ion in mitochondrial 15 S rRNA
@en
Mutations in MTO2 related to t ...... ion in mitochondrial 15 S rRNA
@nl
prefLabel
Mutations in MTO2 related to t ...... ion in mitochondrial 15 S rRNA
@ast
Mutations in MTO2 related to t ...... ion in mitochondrial 15 S rRNA
@en
Mutations in MTO2 related to t ...... ion in mitochondrial 15 S rRNA
@nl
P2093
P2860
P3181
P356
P1476
Mutations in MTO2 related to t ...... ion in mitochondrial 15 S rRNA
@en
P2093
Gèrard Faye
Min-Xin Guan
Qingfeng Yan
Xiaoming Li
P2860
P304
P3181
P356
10.1074/JBC.M504247200
P407
P577
2005-08-12T00:00:00Z