about
Computational enzyme design approaches with significant biological outcomes: progress and challengesFundamental challenges in mechanistic enzymology: progress toward understanding the rate enhancements of enzymesBeyond directed evolution--semi-rational protein engineering and designIncreased Diels-Alderase activity through backbone remodeling guided by Foldit players.Exploring protein fitness landscapes by directed evolutionDesign and engineering of an O(2) transport proteinComputational design of Candida boidinii xylose reductase for altered cofactor specificityThe farther, the safer: a manifesto for securely navigating synthetic species away from the old living worldConsensus protein designEngineering and Evolution of Molecular Chaperones and Protein Disaggregases with Enhanced ActivityProtein stability: computation, sequence statistics, and new experimental methodsEngineering oxidoreductases: maquette proteins designed from scratchProtein design: toward functional metalloenzymesShedding light on protein folding, structural and functional dynamics by single molecule studiesA new paradigm of DNA synthesis: three-metal-ion catalysis.Testing Geometrical Discrimination within an Enzyme Active Site: Constrained Hydrogen Bonding in the Ketosteroid Isomerase Oxyanion HoleUsing affinity chromatography to engineer and characterize pH-dependent protein switchesEstablishing wild-type levels of catalytic activity on natural and artificial ( )8-barrel protein scaffoldsThe pKa Values of Acidic and Basic Residues Buried at the Same Internal Location in a Protein Are Governed by Different FactorsAlteration of enzyme specificity by computational loop remodeling and designStructural Basis for Exquisite Specificity of Affinity Clamps, Synthetic Binding Proteins Generated through Directed Domain-interface EvolutionComputational design of ligand binding is not a solved problemAn aspartate and a water molecule mediate efficient acid-base catalysis in a tailored antibody pocketRational design of a structural and functional nitric oxide reductaseDirect Observation of an Enamine Intermediate in Amine CatalysisDissecting the paradoxical effects of hydrogen bond mutations in the ketosteroid isomerase oxyanion holeRoles of glutamates and metal ions in a rationally designed nitric oxide reductase based on myoglobinPredicting resistance mutations using protein design algorithmsComputational Design of an Enzyme Catalyst for a Stereoselective Bimolecular Diels-Alder ReactionOptimization of the In-Silico-Designed Kemp Eliminase KE70 by Computational Design and Directed EvolutionComputational design of an endo-1,4- -xylanase ligand binding siteComputational Design of Virus-Like Protein Assemblies on Carbon Nanotube SurfacesComputational Design of Catalytic Dyads and Oxyanion Holes for Ester HydrolysisNovel Conformation of an RNA Structural SwitchPrinciples for designing ideal protein structuresStructural Analyses of Covalent Enzyme–Substrate Analog Complexes Reveal Strengths and Limitations of De Novo Enzyme DesignStructural Insights into the Recovery of Aldolase Activity inN-Acetylneuraminic Acid Lyase by Replacement of the Catalytically Active Lysine with γ-Thialysine by Using a Chemical Mutagenesis StrategyComputational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysisIterative approach to computational enzyme designEvolution of a designed retro-aldolase leads to complete active site remodeling
P2860
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P2860
description
2008 nî lūn-bûn
@nan
2008 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մարտին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
De novo computational design of retro-aldol enzymes
@ast
De novo computational design of retro-aldol enzymes
@en
De novo computational design of retro-aldol enzymes
@nl
type
label
De novo computational design of retro-aldol enzymes
@ast
De novo computational design of retro-aldol enzymes
@en
De novo computational design of retro-aldol enzymes
@nl
altLabel
De Novo Computational Design of Retro-Aldol Enzymes
@en
prefLabel
De novo computational design of retro-aldol enzymes
@ast
De novo computational design of retro-aldol enzymes
@en
De novo computational design of retro-aldol enzymes
@nl
P2093
P2860
P50
P3181
P356
P1433
P1476
De novo computational design of retro-aldol enzymes
@en
P2093
Alexandre Zanghellini
Barry L Stoddard
Carlos F Barbas
Daniela Röthlisberger
Donald Hilvert
Eric A Althoff
Fernando R Clemente
Jamie L Betker
Jasmine L Gallaher
Kendall N Houk
P2860
P304
P3181
P356
10.1126/SCIENCE.1152692
P407
P577
2008-03-07T00:00:00Z