Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF - Wikidata - awgldk - TriplyDB

Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF

Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF

http://www.wikidata.org/entity/Q24615826

about

A secretory kinase complex regulates extracellular protein phosphorylation Complexity in KSR function revealed by Raf inhibitor and KSR structure studies Scaffold proteins: hubs for controlling the flow of cellular information Selective disruption of aurora C kinase reveals distinct functions from aurora B kinase during meiosis in mouse oocytes Titin kinase is an inactive pseudokinase scaffold that supports MuRF1 recruitment to the sarcomeric M-line Raf-interactome in tuning the complexity and diversity of Raf function.Biochemistry. KSR plays CRAF-ty Signalling scaffolds and local organization of cellular behaviour The Tribbles 2 (TRB2) pseudokinase binds to ATP and autophosphorylates in a metal-independent manner How Genetics Has Helped Piece Together the MAPK Signaling Pathway.The extracellular signal-regulated kinase 1/2 pathway in neurological diseases: A potential therapeutic target (Review).Caveolin-1 is required for kinase suppressor of Ras 1 (KSR1)-mediated extracellular signal-regulated kinase 1/2 activation, H-RasV12-induced senescence, and transformation Receptor tyrosine kinases with intracellular pseudokinase domains Pseudokinases from a structural perspective Complexity in the signaling network: insights from the use of targeted inhibitors in cancer therapy.The structure of Legionella pneumophila LegK4 type four secretion system (T4SS) effector reveals a novel dimeric eukaryotic-like kinase.Evolution of the eukaryotic protein kinases as dynamic molecular switches.Structural Basis for the Non-catalytic Functions of Protein Kinases.Identification of a Non-Gatekeeper Hot Spot for Drug-Resistant Mutations in mTOR Kinase.RKIP regulates MAP kinase signaling in cells with defective B-Raf activity.Paradoxical activation and RAF inhibitor resistance of BRAF protein kinase fusions characterizing pediatric astrocytomas.BRAF inhibitors suppress apoptosis through off-target inhibition of JNK signaling.SILAC-based phosphoproteomics reveals an inhibitory role of KSR1 in p53 transcriptional activity via modulation of DBC1.Phosphorylation of BRAF by AMPK impairs BRAF-KSR1 association and cell proliferation.Activation of protein kinase PKR requires dimerization-induced cis-phosphorylation within the activation loop.The Biological Function of the Prion Protein: A Cell Surface Scaffold of Signaling Modules It takes two to tango--signalling by dimeric Raf kinases.How scaffolds shape MAPK signaling: what we know and opportunities for systems approaches.Mitogen-Activated Protein (MAP) Kinase Scaffolding Proteins: A Recount.Protein kinase C pharmacology: refining the toolbox.A pickup in pseudokinase activity.The dual function of KSR1: a pseudokinase and beyond.Pseudokinase drug intervention: a potentially poisoned chalice.Kinases and pseudokinases: lessons from RAF.Going for broke: targeting the human cancer pseudokinome.ProKinO: a unified resource for mining the cancer kinome.A-Raf: A new star of the family of raf kinases.Uncoupling Catalytic and Binding Functions in the Cyclic AMP-Dependent Protein Kinase A Phosphoproteomics Reveals MAPK Inhibitors Enhance MET- and EGFR-Driven AKT Signaling in KRAS-Mutant Lung Cancer.KSR1 regulates BRCA1 degradation and inhibits breast cancer growth.

P2860

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P2860

Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF

http://www.wikidata.org/entity/Q24615826

description

2011 nî lūn-bûn

@nan

2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

Mutation that blocks ATP bindi ...... ppressor of Ras, CRAF and BRAF

@ast

Mutation that blocks ATP bindi ...... ppressor of Ras, CRAF and BRAF

@en

Mutation that blocks ATP bindi ...... ppressor of Ras, CRAF and BRAF

@nl

type

label

Mutation that blocks ATP bindi ...... ppressor of Ras, CRAF and BRAF

@ast

Mutation that blocks ATP bindi ...... ppressor of Ras, CRAF and BRAF

@en

Mutation that blocks ATP bindi ...... ppressor of Ras, CRAF and BRAF

@nl

prefLabel

Mutation that blocks ATP bindi ...... ppressor of Ras, CRAF and BRAF

@ast

Mutation that blocks ATP bindi ...... ppressor of Ras, CRAF and BRAF

@en

Mutation that blocks ATP bindi ...... ppressor of Ras, CRAF and BRAF

@nl

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P3181

P356

PNAS.1102554108

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Mutation that blocks ATP bindi ...... ppressor of Ras, CRAF and BRAF

@en

P2093

Andrey S Shaw

http://www.w3.org/2001/XMLSchema#string

Erin L Filbert

http://www.w3.org/2001/XMLSchema#string

Jianping Zhao

http://www.w3.org/2001/XMLSchema#string

Susan S Taylor

http://www.w3.org/2001/XMLSchema#string

P2860

Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF

KSR, a novel protein kinase required for RAS signal transduction

Inflammatory bowel disease reveals the kinase activity of KSR1

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

A dimerization-dependent mechanism drives RAF catalytic activation.

Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization

Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization

The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction

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6067-6072

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

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1602428

http://www.w3.org/2001/XMLSchema#string

P356

10.1073/PNAS.1102554108

http://www.w3.org/2001/XMLSchema#string

P407

P433

15

http://www.w3.org/2001/XMLSchema#string

P478

108

http://www.w3.org/2001/XMLSchema#string

P50

Alexandr P Kornev

P577

2011-03-25T00:00:00Z

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P5875

50867557

http://www.w3.org/2001/XMLSchema#string

P698

21441104

http://www.w3.org/2001/XMLSchema#string

P921

Braf transforming gene

Kinase suppressor of ras 1

P932

3076888

http://www.w3.org/2001/XMLSchema#string