Akt phosphorylates and regulates the orphan nuclear receptor Nur77 - Wikidata - awgldk - TriplyDB

Akt phosphorylates and regulates the orphan nuclear receptor Nur77

Akt phosphorylates and regulates the orphan nuclear receptor Nur77

http://www.wikidata.org/entity/Q24618410

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A systematic comparative and structural analysis of protein phosphorylation sites based on the mtcPTM database Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma.Motif co-regulation and co-operativity are common mechanisms in transcriptional, post-transcriptional and post-translational regulation Nur77 as a survival factor in tumor necrosis factor signaling Transcriptional activation of known and novel apoptotic pathways by Nur77 orphan steroid receptor nor-1 regulates hippocampal axon guidance, pyramidal cell survival, and seizure susceptibility The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine Protooncogene TCL1b functions as an Akt kinase co-activator that exhibits oncogenic potency in vivo.Induction of apoptosis by TPA and VP-16 is through translocation of TR3 Nur77 and retinoid X receptors: crucial factors in dopamine-related neuroadaptation.Down-regulation of NR4A1 in follicular thyroid carcinomas is restored following lithium treatment.Anti-steroidogenic factor ARR19 inhibits testicular steroidogenesis through the suppression of Nur77 transactivation.Epstein-Barr virus EBNA2 blocks Nur77- mediated apoptosis Identification of nerve growth factor-responsive element of the TCL1 promoter as a novel negative regulatory element.Targeting Nur77 translocation.The interplay of NR4A receptors and the oncogene-tumor suppressor networks in cancer Protein kinase C regulates mitochondrial targeting of Nur77 and its family member Nor-1 in thymocytes undergoing apoptosis.The role of NR4A transcription factors in memory formation The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells.Perturbation of the Akt/Gsk3-β signalling pathway is common to Drosophila expressing expanded untranslated CAG, CUG and AUUCU repeat RNAs.Lipid phosphatases in the regulation of T cell activation: living up to their PTEN-tial.Mitochondrial translocation of Nur77 mediates cardiomyocyte apoptosis.The TCL1 family of oncoproteins: co-activators of transformation.From Rapa Nui to rapamycin: targeting PI3K/Akt/mTOR for cancer therapy.Postnatal exposure history and airways: oxidant stress responses in airway explants Nuclear receptors and the Warburg effect in cancer.Mitogenic effect of orphan receptor TR3 and its regulation by MEKK1 in lung cancer cells.TIM family proteins promote the lysosomal degradation of the nuclear receptor NUR77.The Caenorhabditis elegans NR4A nuclear receptor is required for spermatheca morphogenesis.High expression of orphan nuclear receptor NR4A1 in a subset of ovarian tumors with worse outcome.Retinoid X receptor regulates Nur77/TR3-dependent apoptosis [corrected] by modulating its nuclear export and mitochondrial targeting.Control of nuclear receptor activities in metabolism by post-translational modifications.Nur77: a potential therapeutic target in cancer.Non-genomic events determining the sensitivity of hemopoietic malignancies to glucocorticoid-induced apoptosis.Alternative, nonapoptotic programmed cell death: mediation by arrestin 2, ERK2, and Nur77.Roles of leptin, adiponectin and resistin in the transcriptional regulation of steroidogenic genes contributing to decreased Leydig cells function in obesity.The NR4A subfamily of nuclear receptors: potential new therapeutic targets for the treatment of inflammatory diseases.Dimer-specific potentiation of NGFI-B (Nur77) transcriptional activity by the protein kinase A pathway and AF-1-dependent coactivator recruitment.Fas apoptosis inhibitory molecule regulates T cell receptor-mediated apoptosis of thymocytes by modulating Akt activation and Nur77 expression.Akt is transferred to the nucleus of cells treated with apoptin, and it participates in apoptin-induced cell death.

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P2860

Akt phosphorylates and regulates the orphan nuclear receptor Nur77

http://www.wikidata.org/entity/Q24618410

description

2001 nî lūn-bûn

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2001 թուականի Մարտին հրատարակուած գիտական յօդուած

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2001 թվականի մարտին հրատարակված գիտական հոդված

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2001年の論文

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2001年論文

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2001年論文

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2001年論文

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2001年論文

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2001年論文

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2001年论文

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name

Akt phosphorylates and regulates the orphan nuclear receptor Nur77

@ast

Akt phosphorylates and regulates the orphan nuclear receptor Nur77

@en

Akt phosphorylates and regulates the orphan nuclear receptor Nur77

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type

label

Akt phosphorylates and regulates the orphan nuclear receptor Nur77

@ast

Akt phosphorylates and regulates the orphan nuclear receptor Nur77

@en

Akt phosphorylates and regulates the orphan nuclear receptor Nur77

@nl

prefLabel

Akt phosphorylates and regulates the orphan nuclear receptor Nur77

@ast

Akt phosphorylates and regulates the orphan nuclear receptor Nur77

@en

Akt phosphorylates and regulates the orphan nuclear receptor Nur77

@nl

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Akt phosphorylates and regulates the orphan nuclear receptor Nur77

@en

P2093

A Koval

http://www.w3.org/2001/XMLSchema#string

A Palamarchuk

http://www.w3.org/2001/XMLSchema#string

C Hallas

http://www.w3.org/2001/XMLSchema#string

F Bullrich

http://www.w3.org/2001/XMLSchema#string

J Letofsky

http://www.w3.org/2001/XMLSchema#string

R Bichi

http://www.w3.org/2001/XMLSchema#string

Y Hirata

http://www.w3.org/2001/XMLSchema#string

Y Pekarsky

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P2860

Tcl1 enhances Akt kinase activity and mediates its nuclear translocation

Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells

Phosphorylation and regulation of Raf by Akt (protein kinase B)

AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation

NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

Heterodimerization between members of the Nur subfamily of orphan nuclear receptors as a novel mechanism for gene activation

Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

c-Crk, a substrate of the insulin-like growth factor-1 receptor tyrosine kinase, functions as an early signal mediator in the adipocyte differentiation process.

The phosphorylation and DNA binding of the DNA-binding domain of the orphan nuclear receptor NGFI-B.

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3690-4

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scholarly article

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10.1073/PNAS.051003198

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7

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98

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Carlo Maria Croce

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2001-03-27T00:00:00Z

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12059517

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11274386

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P921

phosphorylation

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31113

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