A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target - Wikidata - awgldk - TriplyDB

A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target

A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target

http://www.wikidata.org/entity/Q24623736

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Immune Response of Amebiasis and Immune Evasion by Entamoeba histolytica.Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen Drug Development Against the Major Diarrhea-Causing Parasites of the Small Intestine, Cryptosporidium and Giardia New drug target in protozoan parasites: the role of thioredoxin reductase Computational and Practical Aspects of Drug Repositioning Drug repurposing and human parasitic protozoan diseases Reprofiled drug targets ancient protozoans: drug discovery for parasitic diarrheal diseases Recent advances in Entamoeba biology: RNA interference, drug discovery, and gut microbiome Bioassay-guided fractionation of extracts from Codiaeum variegatum against Entamoeba histolytica discovers compounds that modify expression of ceramide biosynthesis related genes Forward genetic screening identifies a small molecule that blocks Toxoplasma gondii growth by inhibiting both host- and parasite-encoded kinases Praziquantel, mefloquine-praziquantel, and mefloquine-artesunate-praziquantel against Schistosoma haematobium: a randomized, exploratory, open-label trial Auranofin is highly efficacious against Toxoplasma gondii in vitro and in an in vivo experimental model of acute toxoplasmosis Development and validation of a luminescence-based, medium-throughput assay for drug screening in Schistosoma mansoni Repurposing auranofin as a lead candidate for treatment of lymphatic filariasis and onchocerciasis Antiprotozoal Activity Profiling of Approved Drugs: A Starting Point toward Drug Repositioning Resveratrol Induces Apoptosis-Like Death and Prevents In Vitro and In Vivo Virulence of Entamoeba histolytica The elements of life and medicines Entamoeba histolytica-Encoded Homolog of Macrophage Migration Inhibitory Factor Contributes to Mucosal Inflammation during Amebic Colitis.Microfluidic Sample Preparation for Single Cell Analysis.Repurposing the open access malaria box to discover potent inhibitors of Toxoplasma gondii and Entamoeba histolytica Hsp90 inhibitors as new leads to target parasitic diarrheal diseases.Auranofin and related heterometallic gold(I)-thiolates as potent inhibitors of methicillin-resistant Staphylococcus aureus bacterial strains Auranofin induces lethal oxidative and endoplasmic reticulum stress and exerts potent preclinical activity against chronic lymphocytic leukemia.G protein signaling in the parasite Entamoeba histolytica Corifungin, a new drug lead against Naegleria, identified from a high-throughput screen.A reprofiled drug, auranofin, is effective against metronidazole-resistant Giardia lamblia Anti-rheumatic agent auranofin induced apoptosis in chronic myeloid leukemia cells resistant to imatinib through both Bcr/Abl-dependent and -independent mechanisms High-throughput screening of a collection of known pharmacologically active small compounds for identification of Candida albicans biofilm inhibitors KEAP1-dependent synthetic lethality induced by AKT and TXNRD1 inhibitors in lung cancer Substrate selection influences molecular recognition in a screen for lymphoid tyrosine phosphatase inhibitors Repurposing Non-Antimicrobial Drugs and Clinical Molecules to Treat Bacterial Infections Metronidazole-triazole conjugates: activity against Clostridium difficile and parasites Antibacterial activity and mechanism of action of auranofin against multi-drug resistant bacterial pathogens.Chew on this: amoebic trogocytosis and host cell killing by Entamoeba histolytica.Ebselen exerts antifungal activity by regulating glutathione (GSH) and reactive oxygen species (ROS) production in fungal cells.Repurposing Approach Identifies Auranofin with Broad Spectrum Antifungal Activity That Targets Mia40-Erv1 Pathway Leishmania donovani Encodes a Functional Selenocysteinyl-tRNA Synthase.Auranofin induces apoptosis by ROS-mediated ER stress and mitochondrial dysfunction and displayed synergistic lethality with piperlongumine in gastric cancer Repurposing auranofin for the treatment of cutaneous staphylococcal infections.Auranofin-mediated inhibition of PI3K/AKT/mTOR axis and anticancer activity in non-small cell lung cancer cells.

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A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target

http://www.wikidata.org/entity/Q24623736

description

2012 nî lūn-bûn

@nan

2012 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2012 թվականի հունիսին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target

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A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target

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A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target

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A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target

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A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target

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A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target

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A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target

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A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target

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A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target

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Nature Medicine

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A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target

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Amy M Barrios

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Chen He

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Derek Parsonage

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Guillermina García-Rivera

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Ken Hirata

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Leslie B Poole

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Michelle R Arkin

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Máximo B Martínez

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Rosa M Andrade

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Shamila S Gunatilleke

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P2860

A Rae1-containing ribonucleoprotein complex is required for mitotic spindle assembly

Identification of oxadiazoles as new drug leads for the control of schistosomiasis

Inhibition of Schistosoma mansoni thioredoxin-glutathione reductase by auranofin: structural and kinetic aspects

A gold-containing drug against parasitic polyamine metabolism: the X-ray structure of trypanothione reductase from Leishmania infantum in complex with auranofin reveals a dual mechanism of enzyme inhibition

Characterization of Saccharomyces cerevisiae Ras1p and chimaeric constructs of Ras proteins reveals the hypervariable region and farnesylation as critical elements in the adenylyl cyclase signaling pathway.

The importance of glutathione in human disease

Arsenite-inducible RNA-associated protein (AIRAP) protects cells from arsenite toxicity

Thioredoxin glutathione reductase from Schistosoma mansoni: an essential parasite enzyme and a key drug target

Drug repositioning: identifying and developing new uses for existing drugs

The mouse model of amebic colitis reveals mouse strain susceptibility to infection and exacerbation of disease by CD4+ T cells.

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956-60

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scholarly article

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1675847

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10.1038/NM.2758

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6

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18

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James H McKerrow

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2012-06-01T00:00:00Z

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225049681

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1037928183

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22610278

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Entamoeba histolytica

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3411919

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