Identification of granulocyte colony-stimulating factor and interleukin-6 as candidate biomarkers of CBLB502 efficacy as a medical radiation countermeasure - Wikidata - awgldk - TriplyDB

Identification of granulocyte colony-stimulating factor and interleukin-6 as candidate biomarkers of CBLB502 efficacy as a medical radiation countermeasure

Identification of granulocyte colony-stimulating factor and interleukin-6 as candidate biomarkers of CBLB502 efficacy as a medical radiation countermeasure

http://www.wikidata.org/entity/Q24627006

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Central role of liver in anticancer and radioprotective activities of Toll-like receptor 5 agonist γ-Tocotrienol as a Promising Countermeasure for Acute Radiation Syndrome: Current Status New approaches to radiation protection Vitamin E: tocopherols and tocotrienols as potential radiation countermeasures The Toll-Like Receptor 5 Agonist Entolimod Mitigates Lethal Acute Radiation Syndrome in Non-Human Primates Medical countermeasures for unwanted CBRN exposures: part II radiological and nuclear threats with review of recent countermeasure patents Succinate ester derivative of δ-tocopherol enhances the protective effects against (60)Co γ-ray-induced hematopoietic injury through granulocyte colony-stimulating factor induction in mice THE POTENTIATION OF THE RADIOPROTECTIVE EFFICACY OF TWO MEDICAL COUNTERMEASURES, GAMMA-TOCOTRIENOL AND AMIFOSTINE, BY A COMBINATION PROPHYLACTIC MODALITY.Medical Countermeasures for Radiation Exposure and Related Injuries: Characterization of Medicines, FDA-Approval Status and Inclusion into the Strategic National Stockpile.Tocols induce G-CSF and mobilise progenitors that mitigate radiation injury Radiation countermeasure agents: an update (2011-2014)Patents for Toll-like receptor ligands as radiation countermeasures for acute radiation syndrome Combined immunomodulator and antimicrobial therapy eliminates polymicrobial sepsis and modulates cytokine production in combined injured mice Use of biomarkers for assessing radiation injury and efficacy of countermeasures Establishment of a mouse model of 70% lethal dose by total-body irradiation.The effects of antioxidants on gene expression following gamma-radiation (GR) and proton radiation (PR) in mice in vivo.CBLB502 administration protects gut mucosal tissue in ulcerative colitis by inhibiting inflammation.Alpha-tocopherol succinate- and AMD3100-mobilized progenitors mitigate radiation combined injury in mice.Toll-like receptor-5 agonist Entolimod broadens the therapeutic window of 5-fluorouracil by reducing its toxicity to normal tissues in mice.Granulocyte colony-stimulating factor in the treatment of acute radiation syndrome: a concise review.Animal models for acute radiation syndrome drug discovery.A review of radiation countermeasures focusing on injury-specific medicinals and regulatory approval status: part II. Countermeasures for limited indications, internalized radionuclides, emesis, late effects, and agents demonstrating efficacy in lar Toll-like receptor 5 agonist CBLB502 induces radioprotective effects in vitro.Nonhuman primates as models for the discovery and development of radiation countermeasures.A review of radiation countermeasures focusing on injury-specific medicinals and regulatory approval status: part I. Radiation sub-syndromes, animal models and FDA-approved countermeasures.Pharmacological Modulation of Radiation Damage. Does It Exist a Chance for Other Substances than Hematopoietic Growth Factors and Cytokines?Rescuing Self: Transient Isolation and Autologous Transplantation of Bone Marrow Mitigates Radiation-Induced Hematopoietic Syndrome and Mortality in Mice.Biologics as countermeasures for acute radiation syndrome: where are we now?Pharmacologically induced reversible hypometabolic state mitigates radiation induced lethality in mice.The Toll-Like Receptor 2/6 Agonist, FSL-1 Lipopeptide, Therapeutically Mitigates Acute Radiation Syndrome.Radioprotective and radiomitigative effects of BP-C2, a novel lignin-derived polyphenolic composition with ammonium molybdate, in two mouse strains exposed to total body irradiation.Mitigation of Radiation-Induced Epithelial Damage by the TLR5 Agonist Entolimod in a Mouse Model of Fractionated Head and Neck Irradiation.Intein-mediated backbone cyclization of entolimod confers enhanced radioprotective activity in mouse models.

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Identification of granulocyte colony-stimulating factor and interleukin-6 as candidate biomarkers of CBLB502 efficacy as a medical radiation countermeasure

http://www.wikidata.org/entity/Q24627006

description

2012 nî lūn-bûn

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2012 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2012 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2012年の論文

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Identification of granulocyte ...... dical radiation countermeasure

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Identification of granulocyte ...... dical radiation countermeasure

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Identification of granulocyte ...... dical radiation countermeasure

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Identification of granulocyte ...... dical radiation countermeasure

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JPET.112.196071

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Journal of Pharmacology and Experimental Therapeutics

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Identification of granulocyte ...... dical radiation countermeasure

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Alec Cheney

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Alexander N Shakhov

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Andrei Purmal

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Andrei V Gudkov

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Elena Feinstein

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Frederick Bone

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Inna Shyshynova

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Mark H Whitnall

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Ratan K Maitra

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Vadim I Krivokrysenko

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Toll-like receptors

Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression

NF-kappaB and the immune response

Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis

NF-kappaB at the crossroads of life and death

In vivo protection against gamma-irradiation with 5-androstenediol.

In vivo effects of interleukin-6 on thrombopoiesis in healthy and irradiated primates.

5-androstenediol improves survival in clinically unsupported rhesus monkeys with radiation-induced myelosuppression.

Combination therapy for radiation-induced bone marrow aplasia in nonhuman primates using synthokine SC-55494 and recombinant human granulocyte colony-stimulating factor.

A stop codon polymorphism of Toll-like receptor 5 is associated with resistance to systemic lupus erythematosus.

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497-508

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