Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells.
about
LAMP1/CD107a is required for efficient perforin delivery to lytic granules and NK-cell cytotoxicityNatural Killer Cell Immunomodulation: Targeting Activating, Inhibitory, and Co-stimulatory Receptor Signaling for Cancer ImmunotherapyCytotoxic granule secretion by lymphocytes and its link to immune homeostasisMolecular characterization of HCMV-specific immune responses: Parallels between CD8(+) T cells, CD4(+) T cells, and NK cellsAn immunology primer for computational modelersMore than a pore: the cellular response to cholesterol-dependent cytolysinsThe unmet need in the elderly: how immunosenescence, CMV infection, co-morbidities and frailty are a challenge for the development of more effective influenza vaccinesVisualization of cytolytic T cell differentiation and granule exocytosis with T cells from mice expressing active fluorescent granzyme BMelanoma cell lysosome secretory burst neutralizes the CTL-mediated cytotoxicity at the lytic synapseImmunological battlefield in gastric cancer and role of immunotherapiesImmunotherapeutic targeting of membrane Hsp70-expressing tumors using recombinant human granzyme BGranzyme B enters the mitochondria in a Sam50-, Tim22- and mtHsp70-dependent manner to induce apoptosis.Repair of a Bacterial Small β-Barrel Toxin Pore Depends on Channel WidthImaging burst kinetics and spatial coordination during serial killing by single natural killer cells.Granzyme B degradation by autophagy decreases tumor cell susceptibility to natural killer-mediated lysis under hypoxia.Gene transcripts associated with muscle strength: a CHARGE meta-analysis of 7,781 persons.Antigen-specific CD8+ T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin.Effects of MACPF/CDC proteins on lipid membranes.Ectopically expressed perforin-1 is proapoptotic in tumor cell lines by increasing caspase-3 activity and the nuclear translocation of cytochrome CInterleukin-15-induced CD56(+) myeloid dendritic cells combine potent tumor antigen presentation with direct tumoricidal potential.Perforin oligomers form arcs in cellular membranes: a locus for intracellular delivery of granzymes.Perforin activity at membranes leads to invaginations and vesicle formation.Regulatory T cells expressing granzyme B play a critical role in controlling lung inflammation during acute viral infection.Symmetry breaking: bispecific antibodies, the beginnings, and 50 years onPacking a punch: the mechanism of pore formation by cholesterol dependent cytolysins and membrane attack complex/perforin-like proteins.Membrane Repair: Mechanisms and Pathophysiology.Human NK cell lytic granules and regulation of their exocytosisCytotoxic T Cells Use Mechanical Force to Potentiate Target Cell KillingIn Vivo Killing Capacity of Cytotoxic T Cells Is Limited and Involves Dynamic Interactions and T Cell Cooperativity.The C-ETS2-TFEB Axis Promotes Neuron Survival under Oxidative Stress by Regulating Lysosome ActivityThe multifaceted role of autophagy in tumor evasion from immune surveillanceCaveolae internalization repairs wounded cells and muscle fibers.Rapid reuptake of granzyme B leads to emperitosis: an apoptotic cell-in-cell death of immune killer cells inside tumor cells.Degranulation Response in Cytotoxic Rat Lymphocytes Measured with a Novel CD107a Antibody.Fas ligand and lytic granule differentially control cytotoxic dynamics of natural killer cell against cancer targetRegulation of Murine Natural Killer Cell Development.IL-2 augments the therapeutic efficacy of adoptively transferred B cells which directly kill tumor cells via the CXCR4/CXCL12 and perforin pathways.Co-expression of perforin and granzyme B genes induces apoptosis and inhibits the tumorigenicity of laryngeal cancer cell line Hep-2.The perforin pore facilitates the delivery of cationic cargos.Live or let die: posttranscriptional gene regulation in cell stress and cell death.
P2860
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P2860
Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells.
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Perforin pores in the endosoma ...... to the cytosol of target cells
@nl
Perforin pores in the endosoma ...... o the cytosol of target cells.
@ast
Perforin pores in the endosoma ...... o the cytosol of target cells.
@en
type
label
Perforin pores in the endosoma ...... to the cytosol of target cells
@nl
Perforin pores in the endosoma ...... o the cytosol of target cells.
@ast
Perforin pores in the endosoma ...... o the cytosol of target cells.
@en
prefLabel
Perforin pores in the endosoma ...... to the cytosol of target cells
@nl
Perforin pores in the endosoma ...... o the cytosol of target cells.
@ast
Perforin pores in the endosoma ...... o the cytosol of target cells.
@en
P2093
P2860
P3181
P356
P1433
P1476
Perforin pores in the endosoma ...... o the cytosol of target cells.
@en
P2093
Denis Martinvalet
Dennis Keefe
Emmanuel Boucrot
Ing Swie Goping
Jerome Thiery
Judy Lieberman
Michael Walch
R Chris Bleackley
Tomas Kirchhausen
P2860
P304
P3181
P356
10.1038/NI.2050
P407
P577
2011-06-19T00:00:00Z