Arg60 to Leu mutation of the human thromboxane A2 receptor in a dominantly inherited bleeding disorder
about
Two thromboxane A2 receptor isoforms in human platelets. Opposite coupling to adenylyl cyclase with different sensitivity to Arg60 to Leu mutationPlatelet signal transduction defect with Galpha subunit dysfunction and diminished Galphaq in a patient with abnormal platelet responsesInherited platelet disorders: toward DNA-based diagnosisHuman thromboxane A2 receptor genetic variants: in silico, in vitro and "in platelet" analysisMultiscale prediction of patient-specific platelet function under flowThromboxane and the thromboxane receptor in cardiovascular disease.Chaperoning G protein-coupled receptors: from cell biology to therapeuticsMicrofluidic assay of platelet deposition on collagen by perfusion of whole blood from healthy individuals taking aspirinSite-directed mutations and the polymorphic variant Ala160Thr in the human thromboxane receptor uncover a structural role for transmembrane helix 4Impact of vascular thromboxane prostanoid receptor activation on hemostasis, thrombosis, oxidative stress, and inflammation.Prostanoid receptors: ontogeny and implications in vascular physiology.Rare platelet GPCR variants: what can we learn?Genetic variations in human G protein-coupled receptors: implications for drug therapy.Understanding the role of prostaglandin E2 in regulating human platelet activity in health and diseaseMolecular Architecture of G Protein-Coupled Receptors.A novel thromboxane A2 receptor D304N variant that abrogates ligand binding in a patient with a bleeding diathesisDeletion of MAP2K2/MEK2: a novel mechanism for a RASopathy?Coactivation of two different G protein-coupled receptors is essential for ADP-induced platelet aggregation.The G protein-coupled receptors: pharmacogenetics and disease.Putative role of prostaglandin receptor in intracerebral hemorrhage.Brain-penetrant tetrahydronaphthalene thromboxane A2-prostanoid (TP) receptor antagonists as prototype therapeutics for Alzheimer's disease.What's new in using platelet research? To unravel thrombopathies and other human disorders.Evaluation of participants with suspected heritable platelet function disorders including recommendation and validation of a streamlined agonist panel.Coagulation defects and altered hemodynamic responses in mice lacking receptors for thromboxane A2Effect of pharmaceutical interventions targeting thromboxane receptors and thromboxane synthase in cardiovascular and renal diseases.Eicosanoids and their drugs in cardiovascular diseases: focus on atherosclerosis and stroke.Congenital defects of platelet function.Cyclooxygenase metabolites in the kidney.Differential signaling by the thromboxane receptor isoforms via the novel GTP-binding protein, Gh.Multiple factors regulating the expression of human thromboxane synthase gene.Molecular mechanisms of target recognition by lipid GPCRs: relevance for cancer.Predicting G protein-coupled receptor downstream signaling by tissue expression.Regulation of the human thromboxane A2 receptor gene by Sp1, Egr1, NF-E2, GATA-1, and Ets-1 in megakaryocytes.The alpha, but not the beta, isoform of the human thromboxane A2 receptor is a target for prostacyclin-mediated desensitization.Mutagenic analysis of platelet thromboxane receptor cysteines. Roles in ligand binding and receptor-effector coupling.Inverse agonism of SQ 29,548 and Ramatroban on Thromboxane A2 receptor.New insights into structural determinants for prostanoid thromboxane A2 receptor- and prostacyclin receptor-G protein coupling.Pathogenetic analysis of three cases with a bleeding disorder characterized by defective platelet aggregation induced by Ca2+ ionophores.Platelet dysfunction associated with the novel Trp29Cys thromboxane A₂ receptor variant.Bleeding tendency and impaired platelet function in a patient carrying a heterozygous mutation in the thromboxane A2 receptor.
P2860
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P2860
Arg60 to Leu mutation of the human thromboxane A2 receptor in a dominantly inherited bleeding disorder
description
1994 nî lūn-bûn
@nan
1994 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
Arg60 to Leu mutation of the h ...... ly inherited bleeding disorder
@ast
Arg60 to Leu mutation of the h ...... ly inherited bleeding disorder
@en
Arg60 to Leu mutation of the h ...... ly inherited bleeding disorder
@nl
type
label
Arg60 to Leu mutation of the h ...... ly inherited bleeding disorder
@ast
Arg60 to Leu mutation of the h ...... ly inherited bleeding disorder
@en
Arg60 to Leu mutation of the h ...... ly inherited bleeding disorder
@nl
prefLabel
Arg60 to Leu mutation of the h ...... ly inherited bleeding disorder
@ast
Arg60 to Leu mutation of the h ...... ly inherited bleeding disorder
@en
Arg60 to Leu mutation of the h ...... ly inherited bleeding disorder
@nl
P2093
P2860
P356
P1476
Arg60 to Leu mutation of the h ...... ly inherited bleeding disorder
@en
P2093
P2860
P304
P356
10.1172/JCI117510
P407
P577
1994-10-01T00:00:00Z