The tumor inhibitor and antiangiogenic agent withaferin A targets the intermediate filament protein vimentin - Wikidata - awgldk - TriplyDB

The tumor inhibitor and antiangiogenic agent withaferin A targets the intermediate filament protein vimentin

The tumor inhibitor and antiangiogenic agent withaferin A targets the intermediate filament protein vimentin

http://www.wikidata.org/entity/Q24633116

about

Distinct roles for CARMIL isoforms in cell migration.The intermediate filament protein, vimentin, is a regulator of NOD2 activity Vimentin, colon cancer progression and resistance to butyrate and other HDACis Withaferin A disrupts ubiquitin-based NEMO reorganization induced by canonical NF-κB signaling Withania somnifera root extract inhibits mammary cancer metastasis and epithelial to mesenchymal transition A novel MMP-2 inhibitor 3-azidowithaferin A (3-azidoWA) abrogates cancer cell invasion and angiogenesis by modulating extracellular Par-4 Dynamic self-guiding analysis of Alzheimer's disease.Human iPSC-derived endothelial cell sprouting assay in synthetic hydrogel arrays Vimentin is a novel anti-cancer therapeutic target; insights from in vitro and in vivo mice xenograft studies Withaferin a alters intermediate filament organization, cell shape and behavior Withaferin-A reduces type I collagen expression in vitro and inhibits development of myocardial fibrosis in vivo Withaferin A inhibits the proteasome activity in mesothelioma in vitro and in vivo Methods for Determining the Cellular Functions of Vimentin Intermediate Filaments Neuromuscular synapse integrity requires linkage of acetylcholine receptors to postsynaptic intermediate filament networks via rapsyn-plectin 1f complexes.Real-time analysis of epithelial-mesenchymal transition using fluorescent single-domain antibodies Withaferin A Analogs That Target the AAA+ Chaperone p97.Protective effect of Withaferin-A on micronucleus frequency and detoxication agents during experimental oral carcinogenesis.Withaferin A inhibits experimental epithelial-mesenchymal transition in MCF-10A cells and suppresses vimentin protein level in vivo in breast tumors.Vimentin is involved in peptidylarginine deiminase 2-induced apoptosis of activated Jurkat cells.Withaferin A targets intermediate filaments glial fibrillary acidic protein and vimentin in a model of retinal gliosis Proinflammatory Cytokines IL-6 and TNF-α Increased Telomerase Activity through NF-κB/STAT1/STAT3 Activation, and Withaferin A Inhibited the Signaling in Colorectal Cancer Cells.Expression of peptidylarginine deiminase 4 in an alkali injury model of retinal gliosis.Differential chemosensitization of P-glycoprotein overexpressing K562/Adr cells by withaferin A and Siamois polyphenols Elucidating Molecular Interactions of Natural Inhibitors with HPV-16 E6 Oncoprotein through Docking Analysis Novel human mPGES-1 inhibitors identified through structure-based virtual screening.Withaferin A induces p53-dependent apoptosis by repression of HPV oncogenes and upregulation of tumor suppressor proteins in human cervical cancer cells.Olfactomedin-4 regulation by estrogen in the human endometrium requires epidermal growth factor signaling.Arylquins target vimentin to trigger Par-4 secretion for tumor cell apoptosis Tumor necrosis factor-α sensitizes breast cancer cells to natural products with proteasome-inhibitory activity leading to apoptosis Covalent modification of the NF-κB essential modulator (NEMO) by a chemical compound can regulate its ubiquitin binding properties in vitro.Withaferin A effectively targets soluble vimentin in the glaucoma filtration surgical model of fibrosis.PARP-1 regulates metastatic melanoma through modulation of vimentin-induced malignant transformation.Role of the cytoskeleton in formation and maintenance of angiogenic sprouts Effective Alu repeat based RT-Qpcr normalization in cancer cell perturbation experiments Withaferin A targets heat shock protein 90 in pancreatic cancer cells.4β-Hydroxywithanolide E isolated from Physalis pruinosa calyx decreases inflammatory responses by inhibiting the NF-κB signaling in diabetic mouse adipose tissue.Metastatic breast cancer cells in the bone marrow microenvironment: novel insights into oncoprotection.Vimentin in cancer and its potential as a molecular target for cancer therapy.Cell death induced by the Jak2 inhibitor, G6, correlates with cleavage of vimentin filaments.Vimentin is sufficient and required for wound repair and remodeling in alveolar epithelial cells.

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P2860

The tumor inhibitor and antiangiogenic agent withaferin A targets the intermediate filament protein vimentin

http://www.wikidata.org/entity/Q24633116

description

2007 nî lūn-bûn

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2007 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2007 թվականի հունիսին հրատարակված գիտական հոդված

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2007年の論文

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2007年论文

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The tumor inhibitor and antian ...... iate filament protein vimentin

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The tumor inhibitor and antian ...... iate filament protein vimentin

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J.CHEMBIOL.2007.04.010

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Chemistry and Biology

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Adel Hamza

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Chang-Guo Zhan

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David M Markovitz

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Kyung Bo Kim

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Nicole Wendschlag

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Nirit Mor-Vaknin

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Paola Bargagna-Mohan

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Robert M Evans

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Royce Mohan

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Yang-eon Kim

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P2860

Conserved segments 1A and 2B of the intermediate filament dimer: their atomic structures and role in filament assembly

Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity

The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2

Plakins: a family of versatile cytolinker proteins

Angiogenesis in cancer, vascular, rheumatoid and other disease

The intermediate filament protein vimentin is a new target for epigallocatechin gallate.

Chemical genetics: exploring and controlling cellular processes with chemical probes.

Impaired wound healing in embryonic and adult mice lacking vimentin.

Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review.

Mice lacking vimentin develop and reproduce without an obvious phenotype.

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623-634

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