Structure-function analysis of the bestrophin family of anion channels
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Bestrophin-1 enables Ca2+-activated Cl- conductance in epitheliaMissense mutations in a retinal pigment epithelium protein, bestrophin-1, cause retinitis pigmentosaBEST1 expression in the retinal pigment epithelium is modulated by OTX family membersMolecular and functional analyses of two new calcium-activated chloride channel family members from mouse eye and intestineChloride channels as drug targets.Anoctamin/TMEM16 family members are Ca2+-activated Cl- channelsDysregulation of human bestrophin-1 by ceramide-induced dephosphorylationFunctional roles of bestrophins in ocular epitheliaBestrophin-2 is a candidate calcium-activated chloride channel involved in olfactory transductionThe bestrophin- and TMEM16A-associated Ca(2+)- activated Cl(–) channels in vascular smooth musclesA C-terminally truncated mouse Best3 splice variant targets and alters the ion balance in lysosome-endosome hybrids and the endoplasmic reticulum.Human disease-causing mutations disrupt an N-C-terminal interaction and channel function of bestrophin 1VMD2 promoter requires two proximal E-box sites for its activity in vivo and is regulated by the MITF-TFE familyMolecular physiology of bestrophins: multifunctional membrane proteins linked to best disease and other retinopathiesA short motif in the C-terminus of mouse bestrophin 3 [corrected] inhibits its activation as a Cl channelThe light peak of the electroretinogram is dependent on voltage-gated calcium channels and antagonized by bestrophin (best-1)Bestrophin Cl- channels are highly permeable to HCO3-Molecular evolution and functional divergence of the bestrophin protein familyEffects of alternative splicing on the function of bestrophin-1 calcium-activated chloride channelsThe best disease-linked Cl- channel hBest1 regulates Ca V 1 (L-type) Ca2+ channels via src-homology-binding domains.Biallelic mutation of BEST1 causes a distinct retinopathy in humansSLO-2 isoforms with unique Ca(2+) - and voltage-dependence characteristics confer sensitivity to hypoxia in C. elegans.Stoichiometry and specific assembly of Best ion channelsGene expression profiling in gills of the great spider crab Hyas araneus in response to ocean acidification and warming.Mouse bestrophin-2 is a bona fide Cl(-) channel: identification of a residue important in anion binding and conduction.Determinants of anion permeation in the second transmembrane domain of the mouse bestrophin-2 chloride channel.The role of bestrophin in airway epithelial ion transport.Drosophila bestrophin-1 chloride current is dually regulated by calcium and cell volume.Lineage-specific expression of bestrophin-2 and bestrophin-4 in human intestinal epithelial cellsActivation of bestrophin Cl- channels is regulated by C-terminal domains.Regulation of bestrophins by Ca2+: a theoretical and experimental study.Mechanism of olfactory masking in the sensory cilia.Functional and clinical data of Best vitelliform macular dystrophy patients with mutations in the BEST1 gene.Bestrophin-2 is involved in the generation of intraocular pressure.Hydrodynamic properties of porcine bestrophin-1 in Triton X-100.A model of best vitelliform macular dystrophy in ratsChloride channels: often enigmatic, rarely predictable.Tmem16A encodes the Ca2+-activated Cl- channel in mouse submandibular salivary gland acinar cellsBestrophins and retinopathies.Role of the Ca2+ -activated Cl- channels bestrophin and anoctamin in epithelial cells.
P2860
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P2860
Structure-function analysis of the bestrophin family of anion channels
description
2003 nî lūn-bûn
@nan
2003 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Structure-function analysis of the bestrophin family of anion channels
@ast
Structure-function analysis of the bestrophin family of anion channels
@en
Structure-function analysis of the bestrophin family of anion channels
@nl
type
label
Structure-function analysis of the bestrophin family of anion channels
@ast
Structure-function analysis of the bestrophin family of anion channels
@en
Structure-function analysis of the bestrophin family of anion channels
@nl
prefLabel
Structure-function analysis of the bestrophin family of anion channels
@ast
Structure-function analysis of the bestrophin family of anion channels
@en
Structure-function analysis of the bestrophin family of anion channels
@nl
P2093
P2860
P3181
P356
P1476
Structure-function analysis of the bestrophin family of anion channels
@en
P2093
Hugh Cahill
John Williams
King-Wai Yau
Takashi Tsunenari
P2860
P304
P3181
P356
10.1074/JBC.M306150200
P407
P577
2003-10-17T00:00:00Z