RNase H activity: structure, specificity, and function in reverse transcription
about
Ribonuclease H: properties, substrate specificity and roles in retroviral reverse transcriptionComplexes of HIV-1 RT, NNRTI and RNA/DNA hybrid reveal a structure compatible with RNA degradationCrystal structure of xenotropic murine leukaemia virus-related virus (XMRV) ribonuclease HStructures of HIV-1 RT-RNA/DNA ternary complexes with dATP and nevirapine reveal conformational flexibility of RNA/DNA: insights into requirements for RNase H cleavageComparative biochemical analysis of recombinant reverse transcriptase enzymes of HIV-1 subtype B and subtype C.Catalytic mechanism of RNA backbone cleavage by ribonuclease H from quantum mechanics/molecular mechanics simulations.Novel approaches to inhibiting HIV-1 replication.Multiple nucleotide preferences determine cleavage-site recognition by the HIV-1 and M-MuLV RNases H.Inhibition of the ribonuclease H activity of HIV-1 reverse transcriptase by GSK5750 correlates with slow enzyme-inhibitor dissociation.Mammalian mitochondrial DNA replication intermediates are essentially duplex but contain extensive tracts of RNA/DNA hybrid.Anti-HIV-1 therapeutics: from FDA-approved drugs to hypothetical future targetsHuman immunodeficiency virus reverse transcriptase displays dramatically higher fidelity under physiological magnesium conditions in vitro.Reverse transcriptase in motion: conformational dynamics of enzyme-substrate interactions.HIV-1 Ribonuclease H: Structure, Catalytic Mechanism and Inhibitors.Reverse transcriptases can clamp together nucleic acids strands with two complementary bases at their 3'-termini for initiating DNA synthesisRole of HIV-1 nucleocapsid protein in HIV-1 reverse transcription.HIV-1 reverse transcriptase can simultaneously engage its DNA/RNA substrate at both DNA polymerase and RNase H active sites: implications for RNase H inhibition.Retroviral integrase superfamily: the structural perspective.Conformational preferences underlying reduced activity of a thermophilic ribonuclease H.In vitro application of ribonucleases: comparison of the effects on mRNA and miRNA stability.Mechanism of HIV reverse transcriptase inhibition by zinc: formation of a highly stable enzyme-(primer-template) complex with profoundly diminished catalytic activity.Requirements for efficient minus strand strong-stop DNA transfer in human immunodeficiency virus 1.Interaction of HIV-1 reverse transcriptase ribonuclease H with an acylhydrazone inhibitor.A Novel Leu92 Mutant of HIV-1 Reverse Transcriptase with a Selective Deficiency in Strand Transfer Causes a Loss of Viral Replication.Structural basis of the allosteric inhibitor interaction on the HIV-1 reverse transcriptase RNase H domain.Inhibitors of HIV-1 Reverse Transcriptase-Associated Ribonuclease H Activity.Nucleocapsid protein function in early infection processes.Fidelity of plus-strand priming requires the nucleic acid chaperone activity of HIV-1 nucleocapsid protein.Efavirenz stimulates HIV-1 reverse transcriptase RNase H activity by a mechanism involving increased substrate binding and secondary cleavage activity.Preferred sequences within a defined cleavage window specify DNA 3' end-directed cleavages by retroviral RNases HEntire-Dataset Analysis of NMR Fast-Exchange Titration Spectra: A Mg2+ Titration Analysis for HIV-1 Ribonuclease H Domain.Arm-specific cleavage and mutation during reverse transcription of 2΄,5΄-branched RNA by Moloney murine leukemia virus reverse transcriptasePhysiological Mg2+ Conditions Significantly Alter the Inhibition of HIV-1 and HIV-2 Reverse Transcriptases by Nucleoside and Non-Nucleoside Inhibitors in Vitro.Connection domain mutations N348I and A360V in HIV-1 reverse transcriptase enhance resistance to 3'-azido-3'-deoxythymidine through both RNase H-dependent and -independent mechanisms.Understanding the effect of magnesium ion concentration on the catalytic activity of ribonuclease H through computation: does a third metal binding site modulate endonuclease catalysis?A dual role of divalent metal ions in catalysis and folding of RNase H1 from extreme halophilic archaeon Halobacterium sp. NRC-1.Insights into the structure and activity of prototype foamy virus RNase H.Molecular Alliance of Lymantria dispar Multiple Nucleopolyhedrovirus and a Short Unmodified Antisense Oligonucleotide of Its Anti-Apoptotic IAP-3 Gene: A Novel Approach for Gypsy Moth Control.Mechanism of polypurine tract primer generation by HIV-1 reverse transcriptase.A label-free and enzyme-free signal amplification strategy for a sensitive RNase H activity assay.
P2860
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P2860
RNase H activity: structure, specificity, and function in reverse transcription
description
2008 nî lūn-bûn
@nan
2008 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
RNase H activity: structure, specificity, and function in reverse transcription
@ast
RNase H activity: structure, specificity, and function in reverse transcription
@en
RNase H activity: structure, specificity, and function in reverse transcription
@nl
type
label
RNase H activity: structure, specificity, and function in reverse transcription
@ast
RNase H activity: structure, specificity, and function in reverse transcription
@en
RNase H activity: structure, specificity, and function in reverse transcription
@nl
prefLabel
RNase H activity: structure, specificity, and function in reverse transcription
@ast
RNase H activity: structure, specificity, and function in reverse transcription
@en
RNase H activity: structure, specificity, and function in reverse transcription
@nl
P2860
P1433
P1476
RNase H activity: structure, specificity, and function in reverse transcription
@en
P2093
James J Champoux
Sharon J Schultz
P2860
P304
P356
10.1016/J.VIRUSRES.2007.12.007
P407
P577
2008-06-01T00:00:00Z